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WO2008149215A3 - Procédé pour la préparation de microparticules et nanoparticules lipidiques solides - Google Patents

Procédé pour la préparation de microparticules et nanoparticules lipidiques solides Download PDF

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Publication number
WO2008149215A3
WO2008149215A3 PCT/IB2008/001463 IB2008001463W WO2008149215A3 WO 2008149215 A3 WO2008149215 A3 WO 2008149215A3 IB 2008001463 W IB2008001463 W IB 2008001463W WO 2008149215 A3 WO2008149215 A3 WO 2008149215A3
Authority
WO
WIPO (PCT)
Prior art keywords
nanoparticles
preparation
solid lipid
micro
lipid micro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2008/001463
Other languages
English (en)
Other versions
WO2008149215A2 (fr
Inventor
Luigi Sebastiano Battaglia
Michele Trotta
Roberta Cavalli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universita degli Studi di Torino
Original Assignee
Universita degli Studi di Torino
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universita degli Studi di Torino filed Critical Universita degli Studi di Torino
Publication of WO2008149215A2 publication Critical patent/WO2008149215A2/fr
Publication of WO2008149215A3 publication Critical patent/WO2008149215A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un procédé pour la préparation de microparticules et nanoparticules lipidiques solides comprenant l'étape de mélange d'une solution acide avec une solution aqueuse micellaire comprenant au moins un sel soluble dans l'eau d'un acide gras en présence d'un agent stabilisant polymérique non ionique et biocompatible. Les microparticules et nanoparticules peuvent en outre incorporer un ingrédient actif, en particulier un ingrédient actif thermosensible.
PCT/IB2008/001463 2007-06-08 2008-06-06 Procédé pour la préparation de microparticules et nanoparticules lipidiques solides Ceased WO2008149215A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITTO2007A0004111 2007-06-08
ITTO20070411 ITTO20070411A1 (it) 2007-06-08 2007-06-08 Metodo per la preparazione di micro e nanoparticelle lipidiche solide

Publications (2)

Publication Number Publication Date
WO2008149215A2 WO2008149215A2 (fr) 2008-12-11
WO2008149215A3 true WO2008149215A3 (fr) 2009-01-29

Family

ID=39938328

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/001463 Ceased WO2008149215A2 (fr) 2007-06-08 2008-06-06 Procédé pour la préparation de microparticules et nanoparticules lipidiques solides

Country Status (2)

Country Link
IT (1) ITTO20070411A1 (fr)
WO (1) WO2008149215A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITBO20120094A1 (it) 2012-02-28 2013-08-29 Vincenza Dolo Composizione biocida
ITBO20130376A1 (it) 2013-07-18 2015-01-19 Ferbi Srl Metodo per la preparazione di nanoparticelle lipidiche solide contenenti anticorpi in forma di coppia ionica, mediante la tecnica della coacervazione degli acidi grassi
IT1423780B1 (en) * 2014-03-31 2016-08-22 Policlinico Di Monza Spa Solid lipid nanoparticles to convey anti-tumor drugs beyond blood brain barrier for treating brain tumors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998056362A1 (fr) * 1997-06-12 1998-12-17 Maria Rosa Gasco Composition pharmaceutique sous forme de microparticules lipidiques pouvant etre administrees par voie parenterale

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998056362A1 (fr) * 1997-06-12 1998-12-17 Maria Rosa Gasco Composition pharmaceutique sous forme de microparticules lipidiques pouvant etre administrees par voie parenterale

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GASCO M R: "Solid lipid nanospheres form warm micro-emulsions", PHARMACEUTICAL TECHNOLOGY INTERNATIONAL, INGLEWOOD, CA, US, vol. 9, no. 11, 1 January 1997 (1997-01-01), pages 52 - 58, XP009030038, ISSN: 0164-6826 *
MULLER R H ET AL: "Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 50, no. 1, 3 July 2000 (2000-07-03), pages 161 - 177, XP004257186, ISSN: 0939-6411 *
UGAZIO E ET AL: "The effect of formulation and concentration of cholesteryl butyrate solid lipid nanospheres (SLN) on NIH-H460 cell proliferation", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 52, no. 2, 1 September 2001 (2001-09-01), pages 197 - 202, XP004301067, ISSN: 0939-6411 *
WISSING S A ET AL: "SOLID LIPID NANOPARTICLES (SLN) - A NOVEL CARRIER FOR UV BLOCKERS", PHARMAZIE, DIE, GOVI VERLAG, ESCHBORN, DE, vol. 56, no. 10, 1 January 2001 (2001-01-01), pages 783 - 786, XP001147308, ISSN: 0031-7144 *

Also Published As

Publication number Publication date
WO2008149215A2 (fr) 2008-12-11
ITTO20070411A1 (it) 2008-12-09

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