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WO2008149144A3 - Polypeptides, antibody variable domains and antagonists - Google Patents

Polypeptides, antibody variable domains and antagonists Download PDF

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Publication number
WO2008149144A3
WO2008149144A3 PCT/GB2008/050400 GB2008050400W WO2008149144A3 WO 2008149144 A3 WO2008149144 A3 WO 2008149144A3 GB 2008050400 W GB2008050400 W GB 2008050400W WO 2008149144 A3 WO2008149144 A3 WO 2008149144A3
Authority
WO
WIPO (PCT)
Prior art keywords
antagonists
polypeptides
variable domains
antibody variable
dabs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2008/050400
Other languages
French (fr)
Other versions
WO2008149144A2 (en
Inventor
Armin Sepp
Malgorzata Pupecka
Ian Tomlinson
Carolyn Enever
Laurent Jespers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Domantis Ltd
Original Assignee
Domantis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Domantis Ltd filed Critical Domantis Ltd
Priority to US12/663,509 priority Critical patent/US20110086019A1/en
Priority to US12/663,498 priority patent/US8357780B2/en
Priority to JP2010510883A priority patent/JP2010528646A/en
Priority to EP08750795A priority patent/EP2162466A2/en
Priority to CA002688434A priority patent/CA2688434A1/en
Priority to US12/323,632 priority patent/US20090148437A1/en
Priority to US12/747,203 priority patent/US20100260853A1/en
Priority to CA2707986A priority patent/CA2707986A1/en
Priority to SG2012074878A priority patent/SG185286A1/en
Priority to TW097148298A priority patent/TW200938222A/en
Priority to EA201000785A priority patent/EA201000785A1/en
Priority to AU2008334605A priority patent/AU2008334605B2/en
Priority to CN2008801271605A priority patent/CN102131827A/en
Priority to EP08860520A priority patent/EP2220115A2/en
Priority to JP2010537443A priority patent/JP2011506396A/en
Priority to BRPI0819932A priority patent/BRPI0819932A2/en
Priority to KR1020107015536A priority patent/KR20100098697A/en
Priority to PCT/EP2008/067295 priority patent/WO2009074634A2/en
Publication of WO2008149144A2 publication Critical patent/WO2008149144A2/en
Publication of WO2008149144A3 publication Critical patent/WO2008149144A3/en
Anticipated expiration legal-status Critical
Priority to ZA2010/04093A priority patent/ZA201004093B/en
Priority to US13/299,030 priority patent/US20120134982A1/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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    • A61K2039/543—Mucosal route intranasal
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    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/544—Mucosal route to the airways
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
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  • Virology (AREA)
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  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
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  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)

Abstract

The invention relates to anti-TNFR1 polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for as therapeutics and/or prophylactics that are likely to encounter proteases when administered to a patient, for example for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating inflammatory disease, such as arthritis or COPD.
PCT/GB2008/050400 2007-06-06 2008-06-03 Polypeptides, antibody variable domains and antagonists Ceased WO2008149144A2 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
US12/663,509 US20110086019A1 (en) 2007-06-06 2008-06-03 Polypeptides, antibody variable domains and antagonistsmethods for
US12/663,498 US8357780B2 (en) 2007-06-06 2008-06-03 Polypeptides, antibody variable domains and antagonists methods for
JP2010510883A JP2010528646A (en) 2007-06-06 2008-06-03 Polypeptides, antibody variable domains, and antagonists
EP08750795A EP2162466A2 (en) 2007-12-13 2008-06-03 Polypeptides, antibody variable domains & antagonists
CA002688434A CA2688434A1 (en) 2007-06-06 2008-06-03 Polypeptides, antibody variable domains and antagonists
US12/323,632 US20090148437A1 (en) 2007-06-06 2008-11-26 Polypeptides, antibody variable domains & antagonists
AU2008334605A AU2008334605B2 (en) 2007-12-13 2008-12-11 Polypeptides, antibody variable domains & antagonists
BRPI0819932A BRPI0819932A2 (en) 2007-12-13 2008-12-11 composition, use of a composition, nebulizer, inhaler or intranasal device, processes for producing a pharmaceutical composition and a polypeptide composition, and use of a physiologically acceptable buffer.
SG2012074878A SG185286A1 (en) 2007-12-13 2008-12-11 Compositions for pulmonary delivery
TW097148298A TW200938222A (en) 2007-12-13 2008-12-11 Compositions for pulmonary delivery
EA201000785A EA201000785A1 (en) 2007-12-13 2008-12-11 COMPOSITIONS FOR DELIVERY IN LIGHT
US12/747,203 US20100260853A1 (en) 2007-12-13 2008-12-11 Compositions for pulmonary delivery
CN2008801271605A CN102131827A (en) 2007-12-13 2008-12-11 Compositions for pulmonary delivery of premedication
EP08860520A EP2220115A2 (en) 2007-12-13 2008-12-11 Polypeptides, antibody variable domains & antagonists
JP2010537443A JP2011506396A (en) 2007-12-13 2008-12-11 Pulmonary delivery composition
CA2707986A CA2707986A1 (en) 2007-12-13 2008-12-11 Compositions for pulmonary delivery
KR1020107015536A KR20100098697A (en) 2007-12-13 2008-12-11 Compositions for pulmonary delivery
PCT/EP2008/067295 WO2009074634A2 (en) 2007-12-13 2008-12-11 Compositions for pulmonary delivery
ZA2010/04093A ZA201004093B (en) 2007-12-13 2010-06-08 Compositions for pulmonary delivery
US13/299,030 US20120134982A1 (en) 2007-06-06 2011-11-17 Polypeptides, antibody variable domains & antagonists

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US93363207P 2007-06-06 2007-06-06
US60/933,632 2007-06-06
GBGB0724331.4A GB0724331D0 (en) 2007-12-13 2007-12-13 Compositions for pulmonary delivery
GB0724331.4 2007-12-13

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/050403 Continuation-In-Part WO2008149146A2 (en) 2007-06-06 2008-06-03 Polypeptides, antibody variable domains and antagonists

Related Child Applications (2)

Application Number Title Priority Date Filing Date
PCT/GB2008/050399 Continuation-In-Part WO2008149143A2 (en) 2007-06-06 2008-06-03 Methods for selecting protease resistant polypeptides
US12/323,632 Continuation-In-Part US20090148437A1 (en) 2007-06-06 2008-11-26 Polypeptides, antibody variable domains & antagonists

Publications (2)

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Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005289809A (en) 2001-10-24 2005-10-20 Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) Mutant heavy chain antibody
HUE045710T2 (en) 2005-05-18 2020-01-28 Ablynx Nv Improved nanobodies tm against tumor necrosis factor-alpha
DE102005023617A1 (en) 2005-05-21 2006-11-23 Aspre Ag Method for mixing colors in a display
WO2007114947A2 (en) 2006-04-04 2007-10-11 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
NZ580530A (en) * 2007-06-06 2012-04-27 Domantis Ltd Anti vegf polypeptides, antibody variable domains and antagonists
WO2009127691A1 (en) 2008-04-17 2009-10-22 Ablynx N.V. Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same
CL2009001081A1 (en) 2008-05-06 2010-09-24 Glaxo Group Ltd Process for producing a particulate vehicle comprising dissolving acrylated polybutylcyan in an organic solvent to form a polymeric solution, adding an aqueous solution, mixing and obtaining the particulate vehicle; pharmaceutical composition comprising said vehicle.
BRPI0921319A2 (en) * 2008-11-26 2018-10-16 Glaxo Group Ltd composition, method for dispensing a composition, and for treating, preventing or diagnosing an eye condition, and process for producing a pharmaceutical composition
CN102307897B (en) 2008-12-05 2016-01-20 葛兰素集团有限公司 Method for selecting protease-resistant polypeptides
WO2010081787A1 (en) 2009-01-14 2010-07-22 Domantis Limited IMPROVED TNFα ANTAGONISM, PROPHYLAXIS & THERAPY WITH REDUCED ORGAN NECROSIS
CN102405233B (en) 2009-02-19 2014-11-26 葛兰素集团有限公司 Improved anti-serum albumin binding variants
EA027866B1 (en) * 2009-02-19 2017-09-29 Глэксо Груп Лимитед Improved anti-serum albumin binding variants
EA022925B1 (en) * 2009-02-19 2016-03-31 Глаксо Груп Лимитед Improved anti-tnfr1 polypeptides, antibody variable domains & antagonists
JP2012518398A (en) 2009-02-24 2012-08-16 グラクソ グループ リミテッド Antigen binding construct
WO2010097394A1 (en) 2009-02-24 2010-09-02 Glaxo Group Limited Multivalent and/or multispecific rankl-binding constructs
MX2011010151A (en) * 2009-03-27 2011-12-14 Glaxo Group Ltd Drug fusions and conjugates.
EP2440936A4 (en) 2009-06-08 2013-03-13 Singulex Inc Highly sensitive biomarker panels
WO2011008814A2 (en) 2009-07-14 2011-01-20 Immune Tolerance Institute, Inc., A California Not-For-Profit Corporation Multiplexed measurement of exogenous and endogenous dna
CA2768460A1 (en) * 2009-07-16 2011-01-20 Glaxo Group Limited Antagonists, uses & methods for partially inhibiting tnfr1
EP2459593A2 (en) 2009-07-29 2012-06-06 Glaxo Group Limited Anti-tgf-beta receptor type ii single domain antibodies
CA2774552A1 (en) * 2009-09-30 2011-04-07 Glaxo Group Limited Drug fusions and conjugates with extended half life
CN102686239B (en) * 2009-10-27 2016-02-03 葛兰素集团有限公司 Stable anti-TNFR 1 polypeptides, antibody variable domains and antagonists
JP2013518558A (en) * 2010-02-04 2013-05-23 メディカル リサーチ カウンシル Structured peptide processing
JP2013518853A (en) 2010-02-05 2013-05-23 アブリンクス エン．ヴェー． Peptides capable of binding to serum albumin and compounds, constructs and polypeptides containing the same
US9040668B2 (en) * 2010-05-20 2015-05-26 Glaxo Group Limited Anti-serum albumin binding variants
US9012609B2 (en) 2010-08-13 2015-04-21 Glaxosmithkline Intellectual Property Development Limited Anti-serum albumin binding variants
MX2013002055A (en) 2010-08-20 2013-07-22 Glaxosmithkline Ip Dev Ltd Improved anti-serum albumin binding variants.
EA029793B1 (en) 2010-08-23 2018-05-31 Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем Anti-ox40 antibodies and methods of using the same
WO2012064792A2 (en) 2010-11-09 2012-05-18 Altimab Therapeutics, Inc. Protein complexes for antigen binding and methods of use
JP2014501725A (en) * 2010-11-24 2014-01-23 グラクソ グループ リミテッド Multispecific antigen binding protein targeting HGF
CN102121043B (en) * 2010-12-16 2013-06-05 东华大学 Method for biopanning affinity ligand of bromelin
CA2823104A1 (en) 2011-01-06 2012-07-12 Glaxo Group Limited Ligands that bind tgf-beta receptor ii
MX354243B (en) 2011-04-21 2018-02-20 Bristol Myers Squibb Co Antibody polypeptides that antagonize cd40.
CA2842099A1 (en) * 2011-07-27 2013-01-31 Glaxo Group Limited Antigen binding constructs
UY34254A (en) * 2011-08-17 2013-04-05 Glaxo Group Ltd PROTEINS AND MODIFIED PEPTIDES.
CN104662035A (en) * 2012-09-25 2015-05-27 阿菲博迪公司 albumin binding polypeptide
AU2013342163B2 (en) * 2012-11-08 2018-08-16 F. Hoffmann-La Roche Ltd IL-6 antagonists and uses thereof
US10435475B2 (en) 2014-03-07 2019-10-08 Bristol-Myers Squibb Company Method of using antibody polypeptides that antagonize CD40 to treat IBD
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
AR103173A1 (en) 2014-12-22 2017-04-19 Novarits Ag PHARMACEUTICAL PRODUCTS AND STABLE LIQUID COMPOSITIONS OF ANTIBODIES IL-17
MA41374A (en) 2015-01-20 2017-11-28 Cytomx Therapeutics Inc MATRIX METALLOPROTEASE CLIVABLE AND SERINE PROTEASE CLIVABLE SUBSTRATES AND METHODS OF USE THEREOF
JP6895421B2 (en) 2015-03-31 2021-06-30 ブイエイチスクエアード リミテッド Polypeptide
JP2018511346A (en) * 2015-03-31 2018-04-26 ブイエイチスクエアード リミテッド Polypeptide
CN107427577A (en) 2015-03-31 2017-12-01 韦斯夸尔德有限公司 Peptidic constructs with the cleavable joint of protease
CA2981145C (en) 2015-03-31 2021-05-11 Ildong Pharm Co., Ltd. Pharmaceutical composition for preventing and treating eye diseases, containing, as active ingredient, fusion protein in which tissue-penetrating peptide and anti-vascular endothelial growth factor preparation are fused
RU2727238C2 (en) 2015-09-01 2020-07-21 Илдонг Фармасьютикал Ко., Лтд. Pharmaceutical composition containing as an active ingredient a fused protein in which a tumor-penetrating peptide and an antiangiogenic agent are fused for preventing and treating cancer or angiogenesis-related diseases
US11066465B2 (en) 2015-12-30 2021-07-20 Kodiak Sciences Inc. Antibodies and conjugates thereof
EP3405491A1 (en) 2016-01-21 2018-11-28 VHsquared Limited Polypeptides
JP7224917B2 (en) 2016-03-31 2023-02-20 ソリッソ ファーマシューティカルズ，インク． Composition
WO2018060453A1 (en) 2016-09-30 2018-04-05 Vhsquared Limited Compositions
US10329620B2 (en) 2017-01-12 2019-06-25 Cardioforecast Ltd. Methods and kits for treating cardiovascular disease
CN107376036B (en) * 2017-06-23 2020-01-07 淮阴工学院 A method for constructing an enzyme-responsive multifunctional nanocoating
MX2020009152A (en) 2018-03-02 2020-11-09 Kodiak Sciences Inc IL-6 ANTIBODIES AND FUSION CONSTRUCTS AND CONJUGATES THEREOF.
EP3863660A4 (en) * 2018-10-09 2022-07-06 The Board of Trustees of the Leland Stanford Junior University MANIPULATED VARIANTS OF FIBROBLAST GROWTH FACTOR AS RECEPTOR ANTAGONISTS
CN109234298A (en) * 2018-10-30 2019-01-18 南昌大学 The building of Lactobacillus crispatus ATCC55221 a kind of and its application in treatment puerpera's cracked nipple
BR112021010433A2 (en) 2018-12-06 2021-08-24 Cytomx Therapeutics, Inc. Cleavable matrix metalloprotease and serine or cysteine protease substrates and methods of using them
WO2020254827A1 (en) * 2019-06-21 2020-12-24 Vhsquared Limited Polypeptides
US20220242945A1 (en) 2019-06-21 2022-08-04 Sorriso Pharmaceuticals, Inc. Polypeptides
EP4041312A4 (en) 2019-10-10 2023-12-20 Kodiak Sciences Inc. METHODS OF TREATING AN EYE DISORDER
US20220288226A1 (en) * 2020-08-27 2022-09-15 Enosi Life Sciences Corp. Methods and compositions to treat autoimmune diseases and cancer
CN116847887A (en) 2020-08-27 2023-10-03 伊诺西治疗公司 Methods and compositions for treating autoimmune diseases and cancers
WO2022117569A1 (en) 2020-12-02 2022-06-09 Oncurious Nv A ccr8 antagonist antibody in combination with a lymphotoxin beta receptor agonist antibody in therapy against cancer
WO2025049818A1 (en) 2023-08-29 2025-03-06 Enosi Therapeutics Corporation Tnfr1 antagonists lacking agonist activity and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058820A2 (en) * 2002-12-27 2004-07-15 Domantis Limited Single-domain-effector group and its uses
WO2007049017A2 (en) * 2005-10-24 2007-05-03 Domantis Limited Agents that bind a target in pulmonary tissue for treating respiratory diseases

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2148299B (en) 1983-09-01 1988-01-06 Hybritech Inc Antibody compositions of therapeutic agents having an extended serum half-life
AU634186B2 (en) 1988-11-11 1993-02-18 Medical Research Council Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
CA2016842A1 (en) 1989-05-16 1990-11-16 Richard A. Lerner Method for tapping the immunological repertoire
DK0585287T3 (en) 1990-07-10 2000-04-17 Cambridge Antibody Tech Process for producing specific binding pair elements
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ATE463573T1 (en) 1991-12-02 2010-04-15 Medimmune Ltd PRODUCTION OF AUTOANTIBODIES ON PHAGE SURFACES BASED ON ANTIBODIES SEGMENT LIBRARIES
EP2338512A1 (en) 2000-11-28 2011-06-29 MedImmune, LLC Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
US20060073141A1 (en) * 2001-06-28 2006-04-06 Domantis Limited Compositions and methods for treating inflammatory disorders
GB0118689D0 (en) 2001-08-01 2001-09-19 Psimedica Ltd Pharmaceutical formulation
CA2479212A1 (en) * 2002-03-15 2003-09-25 Brigham And Women's Hospital, Inc. Central airway administration for systemic delivery of therapeutics
US7696320B2 (en) * 2004-08-24 2010-04-13 Domantis Limited Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
EP1517921B1 (en) * 2002-06-28 2006-06-07 Domantis Limited Dual specific ligands with increased serum half-life
US20060002935A1 (en) * 2002-06-28 2006-01-05 Domantis Limited Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor
AU2003270330B2 (en) 2002-09-06 2009-07-30 Alexion Pharmaceuticals, Inc. Method of treatment of asthma using antibodies to complement component C5
ME00204B (en) 2002-09-06 2011-02-10 Medarex Llc Therapeutic human anti-il-1r1 monoclonal antibody
JP2006523090A (en) * 2002-12-27 2006-10-12 ドマンティス リミテッド Bispecific single domain antibody specific for ligand and for ligand receptor
PL1639011T3 (en) * 2003-06-30 2009-05-29 Domantis Ltd Pegylated single domain antibodies (dAb)
US20090191217A1 (en) 2004-12-02 2009-07-30 De Wildt Ruud M Anti-IL-1R1 Single Domain Antibodies And Therapeutic Uses
EA200801166A1 (en) 2005-12-01 2008-12-30 Домантис Лимитед FORMATS OF COMPETITIVE DOMAIN ANTIBODIES THAT ARE ASSOCIATED WITH INTERLEUKIN RECEPTOR FIRST TYPE 1
BRPI0619225A2 (en) 2005-12-01 2017-11-07 Domantis Ltd domain antibody monomer, ligand, isolated and recombinant nucleic acids, vector, host cell, method for producing a ligand dab monomer, pharmaceutical composition, drug delivery device, use of a domain antibody monomer, and, method to treat an inflammatory disease, arthritis or respiratory disease
CA2632417A1 (en) * 2005-12-06 2007-06-14 Domantis Limited Ligands that have binding specificity for egfr and/or vegf and methods of use therefor
LT2068889T (en) 2006-08-10 2020-02-10 Roy C. Levitt Anakinra for use in the treatment of bronchiolitis obliterans syndrome
US20100129354A1 (en) 2006-10-27 2010-05-27 Ablynx N.V. Intranasal delivery of polypeptides and proteins
CA2683791A1 (en) * 2007-06-06 2008-12-11 Domantis Limited Polypeptides, antibody variable domains & antagonists
NZ580530A (en) 2007-06-06 2012-04-27 Domantis Ltd Anti vegf polypeptides, antibody variable domains and antagonists

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058820A2 (en) * 2002-12-27 2004-07-15 Domantis Limited Single-domain-effector group and its uses
WO2007049017A2 (en) * 2005-10-24 2007-05-03 Domantis Limited Agents that bind a target in pulmonary tissue for treating respiratory diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HARMSEN M M ET AL: "Selection and optimization of proteolytically stable llama single-domain antibody fragments for oral immunotherapy.", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY SEP 2006, vol. 72, no. 3, September 2006 (2006-09-01), pages 544 - 551, XP002510773, ISSN: 0175-7598 *

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