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WO2008143880A8 - Effets thérapeutiques des bryostatines, bryologues, et autres substances associées sur des défaillances de mémoire dues ä à des traumatismes crâniens ou à des lésions traumatiques cérébrales - Google Patents

Effets thérapeutiques des bryostatines, bryologues, et autres substances associées sur des défaillances de mémoire dues ä à des traumatismes crâniens ou à des lésions traumatiques cérébrales Download PDF

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Publication number
WO2008143880A8
WO2008143880A8 PCT/US2008/006158 US2008006158W WO2008143880A8 WO 2008143880 A8 WO2008143880 A8 WO 2008143880A8 US 2008006158 W US2008006158 W US 2008006158W WO 2008143880 A8 WO2008143880 A8 WO 2008143880A8
Authority
WO
WIPO (PCT)
Prior art keywords
brain injury
traumatic brain
bryologs
bryostatins
therapeutic effects
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/006158
Other languages
English (en)
Other versions
WO2008143880A3 (fr
WO2008143880A2 (fr
Inventor
Ofer Zohar
Daniel L Alkon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Blanchette Rockefeller Neuroscience Institute
Original Assignee
Blanchette Rockefeller Neuroscience Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2008/001755 external-priority patent/WO2008100449A2/fr
Application filed by Blanchette Rockefeller Neuroscience Institute filed Critical Blanchette Rockefeller Neuroscience Institute
Publication of WO2008143880A2 publication Critical patent/WO2008143880A2/fr
Publication of WO2008143880A3 publication Critical patent/WO2008143880A3/fr
Publication of WO2008143880A8 publication Critical patent/WO2008143880A8/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/5545—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having eight-membered rings not containing additional condensed or non-condensed nitrogen-containing 3-7 membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte: sur l'utilisation de protéines kinases activant ou renforçant le facteur de croissance des nerf (NGF); sur le facteur tiré du cerveau (BDNF); sur d'autres facteurs neurotropes traitant les lésions traumatiques cérébrales (TBI), et spécifiquement, sur des méthodes de traitement des lésions traumatiques cérébrales comprenant les étapes suivantes: identification d'un sujet ayant subi une lésion traumatique cérébrale; administration au sujet d'une quantité efficace d'une préparation pharmaceutique comprenant un activateur de la protéine kinase C (PKC) ou de l'acide 4-méthylcatéchol acétique, dans un excipient ad hoc pour traiter au moins un symptôme de lésion traumatique cérébrale
PCT/US2008/006158 2007-05-24 2008-05-14 Effets thérapeutiques des bryostatines, bryologues, et autres substances associées sur des défaillances de mémoire dues ä à des traumatismes crâniens ou à des lésions traumatiques cérébrales Ceased WO2008143880A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US92466207P 2007-05-24 2007-05-24
US60/924,662 2007-05-24
PCT/US2008/001755 WO2008100449A2 (fr) 2007-02-09 2008-02-11 Effets thérapeutiques des bryostatines, de leurs analogues, et d'autres substances connexes sur l'affaiblissement de la mémoire induite par un traumatisme crânien et sur les lésions cérébrales
US12/068,742 2008-02-11
US12/068,742 US9974832B2 (en) 2007-02-09 2008-02-11 Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury
USPCT/US2008/001755 2008-02-11

Publications (3)

Publication Number Publication Date
WO2008143880A2 WO2008143880A2 (fr) 2008-11-27
WO2008143880A3 WO2008143880A3 (fr) 2009-06-04
WO2008143880A8 true WO2008143880A8 (fr) 2009-08-13

Family

ID=40091420

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/006158 Ceased WO2008143880A2 (fr) 2007-05-24 2008-05-14 Effets thérapeutiques des bryostatines, bryologues, et autres substances associées sur des défaillances de mémoire dues ä à des traumatismes crâniens ou à des lésions traumatiques cérébrales

Country Status (1)

Country Link
WO (1) WO2008143880A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6446624B2 (ja) 2010-07-08 2019-01-09 アルコン、ダニエル・エル． 脳卒中の治療法におけるｐｋｃ活性化因子および抗凝血剤
RU2470302C1 (ru) * 2011-09-21 2012-12-20 Государственное бюджетное образовательное учреждение высшего профессионального образования "Пермская государственная медицинская академия имени академика Е.А. Вагнера" Министерства здравоохранения и социального развития Российской Федерации Способ прогнозирования когнитивных нарушений в отдаленном периоде черепно-мозговой травмы
US20160025704A1 (en) * 2013-03-15 2016-01-28 Daniel L. Alkon Methods for identifying neuroprotective pkc activators
WO2023133230A1 (fr) * 2022-01-08 2023-07-13 Sohn Joanna Monoacétyldiglycérides (plag) en tant qu'agent d'atténuation pour lésion cérébrale traumatique et lésion de reperfusion ischémique

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004004641A2 (fr) * 2002-07-02 2004-01-15 Blanchette Rockefeller Neurosciences Institute Activation de la pkc utilisee pour renforcer la secretion de la sapp-a et pour ameliorer la gognition, au moyen de composes du type bryostatine
US20050065205A1 (en) * 2002-03-07 2005-03-24 Daniel Alkon Methods for Alzheimer's disease treatment and cognitive enhance
US20040229292A1 (en) * 2002-11-26 2004-11-18 Sebastiano Cavallaro Use of FGF-18 in the diagnosis and treatment of memory disorders
CN101541322A (zh) * 2006-07-28 2009-09-23 布朗歇特洛克菲勒神经科学研究所 刺激细胞生长、突触重塑和巩固长期记忆的方法
ES2548766T3 (es) * 2007-02-09 2015-10-20 Blanchette Rockefeller Neurosciences Institute Efectos terapéuticos de las briostatinas, briólogos y otras sustancias relacionadas en alteraciones de la memoria inducidas por trauma craneal y por lesiones cerebrales

Also Published As

Publication number Publication date
WO2008143880A3 (fr) 2009-06-04
WO2008143880A2 (fr) 2008-11-27

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