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WO2008143876A3 - Agents et essais pour moduler une neurodégénérescence - Google Patents

Agents et essais pour moduler une neurodégénérescence Download PDF

Info

Publication number
WO2008143876A3
WO2008143876A3 PCT/US2008/006154 US2008006154W WO2008143876A3 WO 2008143876 A3 WO2008143876 A3 WO 2008143876A3 US 2008006154 W US2008006154 W US 2008006154W WO 2008143876 A3 WO2008143876 A3 WO 2008143876A3
Authority
WO
WIPO (PCT)
Prior art keywords
neurodegeneration
modulating
assays
agents
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/006154
Other languages
English (en)
Other versions
WO2008143876A2 (fr
Inventor
Brent R Stockwell
Benjamin G Hoffstrom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Columbia University in the City of New York
Original Assignee
Columbia University in the City of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Columbia University in the City of New York filed Critical Columbia University in the City of New York
Publication of WO2008143876A2 publication Critical patent/WO2008143876A2/fr
Publication of WO2008143876A3 publication Critical patent/WO2008143876A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/131—Amines acyclic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne des procédés pour moduler une neurodégénérescence. Ces procédés comprennent l'administration à un patient en ayant besoin d'une quantité efficace d'un composé modulant la toxicité cellulaire induite par une protéine disulfure isomérase (PDI). Des composés et des compositions pour traiter de tels patients sont également fournis. En outre, l'invention concerne des essais pour identifier de tels composés.
PCT/US2008/006154 2007-05-14 2008-05-14 Agents et essais pour moduler une neurodégénérescence Ceased WO2008143876A2 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US93020007P 2007-05-14 2007-05-14
US60/930,200 2007-05-14
US93026707P 2007-05-15 2007-05-15
US60/930,267 2007-05-15
US95874807P 2007-07-09 2007-07-09
US60/958,748 2007-07-09
US6350508P 2008-02-04 2008-02-04
US61/063,505 2008-02-04

Publications (2)

Publication Number Publication Date
WO2008143876A2 WO2008143876A2 (fr) 2008-11-27
WO2008143876A3 true WO2008143876A3 (fr) 2009-01-22

Family

ID=40122232

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/006154 Ceased WO2008143876A2 (fr) 2007-05-14 2008-05-14 Agents et essais pour moduler une neurodégénérescence

Country Status (1)

Country Link
WO (1) WO2008143876A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110142799A1 (en) * 2008-06-23 2011-06-16 President And Fellows Of Harvard College Modulation of neurodegenerative disease by modulating xbp-1 activity
US9956236B2 (en) 2011-02-07 2018-05-01 Cornell University Methods for increasing immune responses using agents that directly bind to and activate IRE-1
CA2732440C (fr) * 2011-02-23 2017-10-31 Universite Laval Analogues de la cystamine pour le traitement de la maladie de parkinson
US9873661B2 (en) 2011-10-25 2018-01-23 New York University Small molecule malarial Aldolase-TRAP enhancers and glideosome inhibitors
CN102408431B (zh) * 2011-11-29 2014-07-16 中国中医科学院中药研究所 青蒿素b的制备方法及其在免疫领域的应用
WO2013134774A1 (fr) 2012-03-09 2013-09-12 Cornell University Modulation de la croissance du cancer du sein par modulation de l'activité de la xbp1
EP3521431A1 (fr) 2013-09-25 2019-08-07 Cornell University Composés pour induire l'immunité antitumorale et procédés associés
US10149838B2 (en) * 2013-10-03 2018-12-11 David Wald Small molecule securinine and norsecurinine analogs and their use in inhibiting myeloperoxidase
CN104761572B (zh) * 2015-03-11 2017-04-12 暨南大学 一叶萩型生物碱二聚体类化合物或其可药用盐及其制法和应用
CN107802621A (zh) * 2017-12-06 2018-03-16 中国中医科学院中药研究所 青蒿素b抗神经炎症和治疗神经退行性疾病的用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030118997A1 (en) * 2001-08-10 2003-06-26 Genset, S.A. Human cDNAs and proteins and uses thereof
US20030224360A9 (en) * 1999-12-23 2003-12-04 The Regents Of The University Of California Interventions to mimic the effects of calorie restriction

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030224360A9 (en) * 1999-12-23 2003-12-04 The Regents Of The University Of California Interventions to mimic the effects of calorie restriction
US20030118997A1 (en) * 2001-08-10 2003-06-26 Genset, S.A. Human cDNAs and proteins and uses thereof

Also Published As

Publication number Publication date
WO2008143876A2 (fr) 2008-11-27

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