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WO2008143730A3 - Macrolide compounds and methods of making and using the same - Google Patents

Macrolide compounds and methods of making and using the same Download PDF

Info

Publication number
WO2008143730A3
WO2008143730A3 PCT/US2008/002732 US2008002732W WO2008143730A3 WO 2008143730 A3 WO2008143730 A3 WO 2008143730A3 US 2008002732 W US2008002732 W US 2008002732W WO 2008143730 A3 WO2008143730 A3 WO 2008143730A3
Authority
WO
WIPO (PCT)
Prior art keywords
making
methods
same
macrolide compounds
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/002732
Other languages
French (fr)
Other versions
WO2008143730A2 (en
Inventor
Ashoke Bhattacharjee
Erin M Duffy
Zoltan F Kanyo
Yuanqing Tang
Yusheng Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Melinta Subsidiary Corp
Original Assignee
Rib X Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rib X Pharmaceuticals Inc filed Critical Rib X Pharmaceuticals Inc
Publication of WO2008143730A2 publication Critical patent/WO2008143730A2/en
Publication of WO2008143730A3 publication Critical patent/WO2008143730A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

The present invention provides macrolide compounds containing an oxime or other related functionality useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory, and prokinetic agents.
PCT/US2008/002732 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same Ceased WO2008143730A2 (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US90439507P 2007-02-28 2007-02-28
US90435507P 2007-02-28 2007-02-28
US90439607P 2007-02-28 2007-02-28
US90439207P 2007-02-28 2007-02-28
US90435107P 2007-02-28 2007-02-28
US60/904,355 2007-02-28
US60/904,395 2007-02-28
US60/904,392 2007-02-28
US60/904,351 2007-02-28
US60/904,396 2007-02-28

Publications (2)

Publication Number Publication Date
WO2008143730A2 WO2008143730A2 (en) 2008-11-27
WO2008143730A3 true WO2008143730A3 (en) 2009-05-28

Family

ID=39433908

Family Applications (6)

Application Number Title Priority Date Filing Date
PCT/US2008/002718 Ceased WO2008143729A2 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002716 Ceased WO2008106225A1 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002717 Ceased WO2008106226A2 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002732 Ceased WO2008143730A2 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002658 Ceased WO2008106204A1 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002715 Ceased WO2008106224A1 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same

Family Applications Before (3)

Application Number Title Priority Date Filing Date
PCT/US2008/002718 Ceased WO2008143729A2 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002716 Ceased WO2008106225A1 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002717 Ceased WO2008106226A2 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/US2008/002658 Ceased WO2008106204A1 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002715 Ceased WO2008106224A1 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same

Country Status (1)

Country Link
WO (6) WO2008143729A2 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011026260A (en) * 2009-07-28 2011-02-10 Central Glass Co Ltd Protected 2-fluoropropylamine having leaving group at 3-position or protected n-alkyl-2-fluoropropylamine having leaving group at 3-position
WO2011018510A1 (en) 2009-08-13 2011-02-17 Basilea Pharmaceutica Ag New macrolides and their use
MX2012004341A (en) 2009-10-16 2012-10-05 Rib X Pharmaceuticals Inc Antimicrobial compounds and methods of making and using the same.
AU2010306650B2 (en) 2009-10-16 2016-10-13 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
PH12012500938A1 (en) 2009-11-13 2016-09-16 Receptos Llc Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
HRP20180874T4 (en) 2009-11-13 2024-09-27 Receptos Llc Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
CN101735149B (en) 2009-11-30 2012-04-18 玉溪市维和生物技术有限责任公司 Macrocyclic amide compound with antibacterial and antitumor activities, and preparation method and application thereof
AR085286A1 (en) * 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd MACROLIDO DERIVATIVE REPLACED IN POSITION C-4
WO2012125832A2 (en) * 2011-03-15 2012-09-20 Rib-X Pharmaceuticals, Inc. Antimicrobial agents
EP2706999B1 (en) 2011-05-13 2019-08-28 Celgene International II Sàrl Selective heterocyclic sphingosine 1 phosphate receptor modulators
RU2014102887A (en) 2011-06-30 2015-08-10 Пирамаль Имэджинг Са DIRECT SYNTHESIS OF 18F-FLUORMETOXY COMPOUNDS FOR PET VISUALIZATIONS AND NEW PREDATORS FOR DIRECT RADIOSYNTHESIS OF PROTECTED O - ([18F] Fluoromethyl) Tyrosine Derivatives
CA2851396A1 (en) * 2011-10-17 2013-04-25 Zoetis Llc Novel phenicol antibacterials
JP5857008B2 (en) * 2012-08-20 2016-02-10 大正製薬株式会社 Medicament containing C-4 ″ substituted macrolide derivative
AU2014315050A1 (en) 2013-09-09 2016-03-24 Melinta Therapeutics, Inc. Antimicrobial compunds and methods of making and using the same
MX2016003046A (en) 2013-09-09 2016-09-08 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same.
SG11201707346RA (en) 2015-03-11 2017-10-30 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
CN105001118A (en) * 2015-07-20 2015-10-28 湖南华腾制药有限公司 Method for preparing iodine-containing azido compound
CN105152966A (en) * 2015-07-20 2015-12-16 湖南华腾制药有限公司 Preparation method for azide
CN105153020A (en) * 2015-07-20 2015-12-16 湖南华腾制药有限公司 Preparation method for aromatic azide
WO2017066964A1 (en) * 2015-10-22 2017-04-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents
JP2019515041A (en) 2016-05-06 2019-06-06 メリンタ セラピューティクス、 インコーポレイテッドＭｅｌｉｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Antimicrobial agents and methods of making and using the same
CN106562943B (en) * 2016-11-09 2019-07-16 济南市儿童医院 Memantine and its application in the drug of preparation treatment Acinetobacter bauamnnii infection
WO2018191682A1 (en) * 2017-04-15 2018-10-18 Melinta Therapeutics, Inc. Triazole compounds and methods of making and using the same
WO2018193125A1 (en) * 2017-04-20 2018-10-25 Novintum Biotechnology Gmbh Azithromycin derivatives containing a phosphonium ion as anticancer agents
EP3612543B1 (en) * 2017-04-20 2022-11-23 Rising Tide Foundation Azithromycin derivatives containing a phosphonium ion as anticancer agents
CN108727445B (en) * 2018-06-29 2021-06-11 宜昌东阳光生化制药有限公司 Synthesis method of azithromycin impurity F
CN115724823B (en) * 2021-08-27 2023-11-24 中国科学院大连化学物理研究所 Method for preparing dihydrothiophene derivative
CN115745823B (en) * 2022-11-03 2024-02-23 武夷学院 Preparation method and application of compound
CN116574014B (en) * 2023-05-25 2024-10-22 山东锐顺药业有限公司 Preparation method of zolmitriptan intermediate

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002051855A2 (en) * 2000-12-01 2002-07-04 Kosan Biosciences, Inc. Motilide compounds
WO2004013153A2 (en) * 2002-08-01 2004-02-12 Zambon Group S.P.A. Macrolide compounds endowed with antiinflammatory activity
WO2005085266A2 (en) * 2004-02-27 2005-09-15 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0004085A3 (en) * 1997-10-16 2003-05-28 Pliva Pharm & Chem Works Novel 3,6-hemiketals from the class of 9a-azalides
US6664241B2 (en) * 2000-05-31 2003-12-16 Micrologix Biotech Inc. Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof
US6995143B2 (en) * 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US6992069B2 (en) * 2002-04-30 2006-01-31 Yu-Gui Gu Tricyclic macrolide antibacterial compounds
ES2552682T3 (en) * 2003-03-10 2015-12-01 Merck Sharp & Dohme Corp. Novel antibacterial agents
US20050250713A1 (en) * 2004-04-26 2005-11-10 Bin Zhu 11,12-Cyclic thiocarbamate macrolide antibacterial agents
EP1934237A2 (en) * 2005-08-24 2008-06-25 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same
HRP20171285T1 (en) * 2005-08-24 2017-10-20 Melinta Therapeutics, Inc. Triazole compounds and methods of making and using the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002051855A2 (en) * 2000-12-01 2002-07-04 Kosan Biosciences, Inc. Motilide compounds
WO2004013153A2 (en) * 2002-08-01 2004-02-12 Zambon Group S.P.A. Macrolide compounds endowed with antiinflammatory activity
WO2005085266A2 (en) * 2004-02-27 2005-09-15 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same

Also Published As

Publication number Publication date
WO2008106225A1 (en) 2008-09-04
WO2008106226A2 (en) 2008-09-04
WO2008143729A2 (en) 2008-11-27
WO2008106204A1 (en) 2008-09-04
WO2008143730A2 (en) 2008-11-27
WO2008106224A1 (en) 2008-09-04
WO2008106226A3 (en) 2008-11-20
WO2008143729A3 (en) 2009-05-14

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