WO2008142460A2 - New herbal composition for prevention and treatmant of diabetes melitusa of type (i) and type (ii) - Google Patents
New herbal composition for prevention and treatmant of diabetes melitusa of type (i) and type (ii) Download PDFInfo
- Publication number
- WO2008142460A2 WO2008142460A2 PCT/HR2008/000010 HR2008000010W WO2008142460A2 WO 2008142460 A2 WO2008142460 A2 WO 2008142460A2 HR 2008000010 W HR2008000010 W HR 2008000010W WO 2008142460 A2 WO2008142460 A2 WO 2008142460A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- herba
- plant
- extract
- medical formulation
- leaf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- This invention is related to field of medical herbal compositions. According to the international patent classification this invention is classified as A61K 35/78. Medical compositions comprising ingredients or products thereof with unknown composition whereby those ingredients are of plant source.
- compositions disclosed in WO2005/034973 By use of pharmaceutical compositions disclosed in WO2005/034973, certain negative effects are discovered. Namely, pharmaceutical composition disclosed in the mentioned application was composed of extracts of more than ten plants. Due to such large plant number, the number of possible allergic reactions is increased during the use of the formulation. Moreover, it is noted that the formulation according to the patent application is dissolving very slowly and insufficiently in water which question its resorption abilities. By analyzing a sample with insufficient solubility it is confirmed that the main reason for that is the presence of magnesium stearate. Besides from that, this new invention eliminates one other negative site of the prior art and that is its higroscopy. Technical Solution
- This invention solves mentioned problems by first, excluding the magnesium stearate from the formulation and second, by reduction of the number of plants used for the extract. Furthermore, to make the formulation from this invention as efficient as that from the invention form prior application WO2005/034973 it is added one new plant species but the number of the components necessary for preparation of the extract is dropped from ten to five. Investigation showed that the number of possible allergic reaction dropped for more than 100%. Moreover, the new formulation has excellent water solubility giving a clear solution contrary to the formulation disclosed in patent WO2005/034973 which gives very muddy solution. Finally, by use of solvents different than those disclosed in patent WO2005/034973, time needed for extraction drops to half.
- Formulation of herbal extract disclosed in patent WO2005/034973 is the newest prior art that relates to this invention. In the same patent it is disclosed another pharmaceutical formulation comprising active ingredients from the extract and magnesium stearate.
- quality medical product can be prepared by simple adsorption of the extract from mentioned herbal mixture in mentioned solvent on the physiologically acceptable carrier.
- the said solvent can be used ethanol 96% and as a suitable carrier can be used inulin.
- ethanol 96% a suitable carrier
- inulin a suitable carrier
- ethanol 40- 70% it is not preferred. Namely, that causes inulin granulation so in that case the use of spray-drier or a similar technology is necessary. Contrary to that, inulin solubility into polar non water solvents such as ethanol 96% is negligible.
- inulin can be solved in ethanol 96% without any noticeable granulation resulting to nice suspension of white pellet in clear supernatant. That fact is used as a core stone for a new and very simple adsorption procedure of herbal extract onto solid carrier such as inulin. Final product is easily soluble in water giving fully clear solution.
- an additional ingredient to mediate the solubility of the fat soluble components from the extract in water media is used.
- An example of such an auxiliary component can be gum arabic. That component present even in very low percentage (0,2%) can make conditions for optimal ingredient content of herbal extract in the formulation and for optimal resorption.
- Herbal mixture for extract production comprises following plant species: centaury plant (Centaurii herba) chicory root (Cichorii radix) nettle plant (Urticaie herba) melissa leaf (Melissae herba) cardoon leaf (Cynara cardunculus), wherein the mentioned components might be present in following weight parts that are given according to the mass of the dry mater in relation to the whole plant mass: centaury plant (Centaurii herba) 10 - 20 % chicory root (Cichorii radix) 15 — 25 % nettle plant (Urticaie herba) 25 - 35 % melissa leaf (Melissae herba) 5 - 15 % cardoon leaf (Cynara cardunculus) 20 — 30 %.
- mass proportion of the mentioned plant species are as follows: centaury plant (Centaurii herba) 15 % chicory root (Cichorii radix) 20 % nettle plant (Urticaie herba) 30 % melissa leaf (Melissae herba) 10 % cardoon leaf (Cynara cardunculus) 20 %
- content of the new formulation is characterized by 70 - 90% proportion of inulina, 9 to 29% proportion of the extract and up to 0,1% proportion of gum arabic. In one embodiment of this invention this contents are as follows: 79,8% of inulin, 20% of mentioned extract and 0,2% gum arabic.
- Preparation of the extract f quantities are for preparation of lkg of extract)
- To 2OL vessel with wide mouth are added one by one, 30Og of nettle plant (Urticaie herha), 25Og of cardoon leaf (Cynara cardunculus), 20Og of chicory root (Cichorii radix), 150g of centaury plant (Centaurii herba) and lOOg of melissa leaf (Melissae folium).
- Plant material is covered with 6kg (around 6,4L) ethanol 96%, corked and macerated on room temperature (20-25° C) during 120 hours. After that, prepared material is vacuum extracted and clear filtrate (extract) is weighted.
- Extract is than left to room temperature (20 - 25° C) during 24 hours after which is filtered and stored in dark glass bottles.
- homogenizer for solid matter is added 798,0Og of inulin and after that an earlier prepared solution of gum arabic (2,0Og in 20ml of water). Mixture is homogenized during 5 min. After that around 200,0Og of plant extract in ethanol 96% is added and mixture is homogenized again during 15 min.
- Prepared solid, green and partially granulated mass is taken off the homogenizer and put in shallow pan for draying. The pan is put in a vacuum dryer. Material is dried on 50° C in vacuum on 8-lOmbar during 6 hours. After that, the dried, loose material is shortly milled in the mill to minimize present granule, after which the product is homogenized during 20 min. The product is stored in properly closed plastic or glass bottle and it is consumed so that 2g of granule is solved in coffee cop with worm water.
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Botany (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Disclosed is dietetic formulation comprising extract from five plant species: centaury plant (Centaurii herba) chicory root (Cichorii radix) nettle plant (Urticaie herba) melissa leaf (Melissae herba) cardoon leaf (Cynara cardunculus) and physiologically acceptable carrier. The formulation is useful for prevention and treatment of both types of diabetes.
Description
NEWHERBAL COMPOSITIONFORPREVENTIONAND TREATMANT OFDIABETES MELITUSA OF TYPE (I) AND TYPE (II)
DESCRIPTION OF THE INVENTION
Technical Field
This invention is related to field of medical herbal compositions. According to the international patent classification this invention is classified as A61K 35/78. Medical compositions comprising ingredients or products thereof with unknown composition whereby those ingredients are of plant source.
Technical Problem
By use of pharmaceutical compositions disclosed in WO2005/034973, certain negative effects are discovered. Namely, pharmaceutical composition disclosed in the mentioned application was composed of extracts of more than ten plants. Due to such large plant number, the number of possible allergic reactions is increased during the use of the formulation. Moreover, it is noted that the formulation according to the patent application is dissolving very slowly and insufficiently in water which question its resorption abilities. By analyzing a sample with insufficient solubility it is confirmed that the main reason for that is the presence of magnesium stearate. Besides from that, this new invention eliminates one other negative site of the prior art and that is its higroscopy.
Technical Solution
This invention solves mentioned problems by first, excluding the magnesium stearate from the formulation and second, by reduction of the number of plants used for the extract. Furthermore, to make the formulation from this invention as efficient as that from the invention form prior application WO2005/034973 it is added one new plant species but the number of the components necessary for preparation of the extract is dropped from ten to five. Investigation showed that the number of possible allergic reaction dropped for more than 100%. Moreover, the new formulation has excellent water solubility giving a clear solution contrary to the formulation disclosed in patent WO2005/034973 which gives very muddy solution. Finally, by use of solvents different than those disclosed in patent WO2005/034973, time needed for extraction drops to half.
Prior Art
Formulation of herbal extract disclosed in patent WO2005/034973 is the newest prior art that relates to this invention. In the same patent it is disclosed another pharmaceutical formulation comprising active ingredients from the extract and magnesium stearate.
Disclosure of the Essence of the Invention
It is showed that extract of herbal mixture comprising centaury plant (Centaurii herba), chicory root (Cichorii radix), nettle plant (Urticaie herba), melissa leaf (Melissae herba) cardoon leaf (Cynara cardunculus) simultaneously affects the blood sugar level, triglycerides etc. in the same manner as the extract disclosed in WO2005/034973.
Moreover, it is showed that quality medical product can be prepared by simple adsorption of the extract from mentioned herbal mixture in mentioned solvent on the physiologically acceptable carrier. As an example of the said solvent can be used ethanol 96% and as a suitable carrier can be used inulin. Taking into account the significant inulin solubility into water it is not preferred to use solvents with bigger content of water. Also, use of ethanol 40- 70% it is not preferred. Namely, that causes inulin granulation so
in that case the use of spray-drier or a similar technology is necessary. Contrary to that, inulin solubility into polar non water solvents such as ethanol 96% is negligible. Due to that, inulin can be solved in ethanol 96% without any noticeable granulation resulting to nice suspension of white pellet in clear supernatant. That fact is used as a core stone for a new and very simple adsorption procedure of herbal extract onto solid carrier such as inulin. Final product is easily soluble in water giving fully clear solution. To make the herbal extract content within the medical product more optimal and to make sure that intestine resorption is optimal an additional ingredient to mediate the solubility of the fat soluble components from the extract in water media is used. An example of such an auxiliary component can be gum arabic. That component present even in very low percentage (0,2%) can make conditions for optimal ingredient content of herbal extract in the formulation and for optimal resorption.
Detailed Description of the Invention
Herbal mixture for extract production comprises following plant species: centaury plant (Centaurii herba) chicory root (Cichorii radix) nettle plant (Urticaie herba) melissa leaf (Melissae herba) cardoon leaf (Cynara cardunculus), wherein the mentioned components might be present in following weight parts that are given according to the mass of the dry mater in relation to the whole plant mass: centaury plant (Centaurii herba) 10 - 20 % chicory root (Cichorii radix) 15 — 25 % nettle plant (Urticaie herba) 25 - 35 % melissa leaf (Melissae herba) 5 - 15 % cardoon leaf (Cynara cardunculus) 20 — 30 %.
In one embodiment of this invention mass proportion of the mentioned plant species are as follows: centaury plant (Centaurii herba) 15 % chicory root (Cichorii radix) 20 % nettle plant (Urticaie herba) 30 % melissa leaf (Melissae herba) 10 % cardoon leaf (Cynara cardunculus) 20 %
On the other side, content of the new formulation is characterized by 70 - 90% proportion of inulina, 9 to 29% proportion of the extract and up to 0,1% proportion of gum arabic. In one embodiment of this invention this contents are as follows: 79,8% of inulin, 20% of mentioned extract and 0,2% gum arabic.
Description of One Embodiment of This Invention
Preparation of the extract f quantities are for preparation of lkg of extract) To 2OL vessel with wide mouth are added one by one, 30Og of nettle plant (Urticaie herha), 25Og of cardoon leaf (Cynara cardunculus), 20Og of chicory root (Cichorii radix), 150g of centaury plant (Centaurii herba) and lOOg of melissa leaf (Melissae folium). Plant material is covered with 6kg (around 6,4L) ethanol 96%, corked and macerated on room temperature (20-25° C) during 120 hours. After that, prepared material is vacuum extracted and clear filtrate (extract) is weighted. Bear in mind that in cases when pressing of the plant material after extraction is not applied, a part of the extract is left in the starting material so the final mass of the filtrate is different than that of the starting mass of the ethanol 96%. The same quantity of the ethanol 96% is added again so a mass of 6kg of extract is gained. Namely, usually is added such a quantity of the fresh solvent so to gain first higher relation of the drag to extract. Example: if the weight of the filtrate (extract) shows relation 1:5,89, 0,11 weight parts of fresh solvent is added so the mass of the final extract be six time higher of the mass of the starting plant drag and such product is declared as (1 :6) extract.
Extract is than left to room temperature (20 - 25° C) during 24 hours after which is filtered and stored in dark glass bottles.
Appearance: intensive green, clear fluid smelling to ethanol Density: 0,807-0,809g/cm3.
Preparation of medical powder formulation from the extract
In the homogenizer for solid matter is added 798,0Og of inulin and after that an earlier prepared solution of gum arabic (2,0Og in 20ml of water). Mixture is homogenized during 5 min. After that around 200,0Og of plant extract in ethanol 96% is added and mixture is homogenized again during 15 min. Prepared solid, green and partially granulated mass is taken off the homogenizer and put in shallow pan for draying. The pan is put in a vacuum dryer.
Material is dried on 50° C in vacuum on 8-lOmbar during 6 hours. After that, the dried, loose material is shortly milled in the mill to minimize present granule, after which the product is homogenized during 20 min. The product is stored in properly closed plastic or glass bottle and it is consumed so that 2g of granule is solved in coffee cop with worm water.
Appearance: pale green loose powder with non intense characteristic smell Characteristics: easily water soluble and the solution is clear
Claims
1. Herbal extract comprising components form five plant species: centaury plant (Centaurii herba) chicory root (Cichorii radix) nettle plant (Urticaie herba) melissa leaf (Melissae herba) cardoon leaf (Cynara cardunculus).
2. Herbal extract according to claim 1 wherein the five plant species needed for preparation of the extract are present in weight parts as follows: centaury plant (Centaurii herba) 10 - 20 % chicory root (Cichorii radix) 15 - 25 % nettle plant (Urticaie herba) 25 - 35 % melissa leaf (Melissae herba) 5 — 15 % cardoon leaf (Cynara cardunculus) 20 — 30 %
3. Herbal extract according to claim 2 wherein the five plant species needed for preparation of the extract are present in weight parts as follows: centaury plant (Centaurii herba) 15 % chicory root (Cichorii radix) 20 % nettle plant (Urticaie herba) 30 % melissa leaf (Melissae herba) 10 % cardoon leaf (Cynara cardunculus) 20 %
4. Medical formulation comprising herbal extract according to any of claims 1-3 and physiologically acceptable carrier.
5. Medical formulation according to claim 4 wherein the carrier is inulin.
6. Medical formulation according to claim 4 comprising additional auxiliary compound.
7. Medical formulation according to claim 6 wherein the auxiliary compound is gum arabic.
8. Medical formulation according to claim 4 that is prepared in granulated form.
9. Medical formulation according to claim 8 wherein the granola are easily water soluble.
10. Method for preparation of medical formulation wherein the extract from herbal mixture according to any of claims 1-3 in waterless solvent is adsorbed on inulin by means of auxiliary compound.
11. Method for preparation of medical formulation according to claim 10 wherein the waterless solvent is ethanol 96%.
12. Method for preparation of medical formulation according to claim 11 wherein the gum arabic is used as an auxiliary compound.
13. Medical formulation that is prepared according to method from claims 7-9.
14. Medical formulation that is used for prevention and for treatment of diabetes mellitus of type I and type II.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HRP20070230A | 2007-05-18 | ||
| HR20070230A HRP20070230B1 (en) | 2007-05-18 | 2007-05-18 | NEW HERBAL PREPARATION FOR THE PREVENTION AND TREATMENT OF TYPE (I) AND TYPE (II) DIABETES MELITUS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2008142460A2 true WO2008142460A2 (en) | 2008-11-27 |
| WO2008142460A3 WO2008142460A3 (en) | 2009-01-15 |
Family
ID=46150522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/HR2008/000010 Ceased WO2008142460A2 (en) | 2007-05-18 | 2008-03-20 | New herbal composition for prevention and treatmant of diabetes melitusa of type (i) and type (ii) |
Country Status (2)
| Country | Link |
|---|---|
| HR (1) | HRP20070230B1 (en) |
| WO (1) | WO2008142460A2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103223016A (en) * | 2013-05-06 | 2013-07-31 | 赵全成 | Ginseng, mulberry leaf and chicoric acid composition for treating diabetes |
| WO2018189672A1 (en) * | 2017-04-12 | 2018-10-18 | Herbal E Antioxidant Derivatives S.R.L. Ed In Forma Abbreviata H&Ad S.R.L. | Extracts of cynara cardunculus and citrus aurantium bergamia, combinations thereof, and formulations containing them |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999055351A1 (en) * | 1998-04-23 | 1999-11-04 | Vladimir Leko | Herbal composition and medicament against diabetes mellitus type ii manufactured thereof |
| HRP990080B1 (en) * | 1999-03-12 | 2003-04-30 | Vladimir Leko | Plant mixture and a medical preparation for the treatment of diabetes mellitus, type ii, obtained therefrom |
| HRP980109B1 (en) * | 1998-04-23 | 2003-02-28 | Vladimir Leko | Herb mixture and a medicine against diabetes melitus type ii. obtained therefrom |
| US7056539B2 (en) * | 1999-03-12 | 2006-06-06 | Vladimir Leko | Process and product extracted from herbal composition useful in controlling diabetes mellitus type II |
| MXPA05006178A (en) * | 2002-12-09 | 2006-03-09 | Shaklee Corp | Modification of cyclooxygenase and lipoxygenase activity with asteridae extracts and optionally boswellic acid. |
| HRP20030816B1 (en) * | 2003-10-10 | 2012-05-31 | Leko Vlado | HERBAL PREPARATION IN THE FORM OF CAPSULES AS AN EXCLUSIVE MEDICINE FOR MELLITUS TYPES (I) AND (II) |
| US20070065456A1 (en) * | 2005-09-20 | 2007-03-22 | Woods Cindy J | Nutritional supplements |
-
2007
- 2007-05-18 HR HR20070230A patent/HRP20070230B1/en not_active IP Right Cessation
-
2008
- 2008-03-20 WO PCT/HR2008/000010 patent/WO2008142460A2/en not_active Ceased
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103223016A (en) * | 2013-05-06 | 2013-07-31 | 赵全成 | Ginseng, mulberry leaf and chicoric acid composition for treating diabetes |
| WO2018189672A1 (en) * | 2017-04-12 | 2018-10-18 | Herbal E Antioxidant Derivatives S.R.L. Ed In Forma Abbreviata H&Ad S.R.L. | Extracts of cynara cardunculus and citrus aurantium bergamia, combinations thereof, and formulations containing them |
| KR20190135497A (en) * | 2017-04-12 | 2019-12-06 | 에르발 에 안티옥시단트 데리바티베스 에스.알.엘. 에드 인 포르마 아브레비아타 에이치&에이디 에스.알.엘. | Extracts of Cinar Cardhusculus and Citrus Aurantium bergamia, combinations thereof, and formulations containing them |
| US11311594B2 (en) | 2017-04-12 | 2022-04-26 | Herbal & Antioxident Derivatives, S.R.L. | Extracts of Cynara cardunculus and Citrus aurantium bergamia, combinations thereof, and formulations containing them |
| KR102589895B1 (en) * | 2017-04-12 | 2023-10-20 | 에르발 에 안티옥시단트 데리바티베스 에스.알.엘. 에드 인 포르마 아브레비아타 에이치＆에이디 에스.알.엘. | Extracts of Cinara cardunculus and Citrus aurantium bergamia, combinations thereof, and preparations containing them |
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20070230A9 (en) | 2008-12-31 |
| HRP20070230A2 (en) | 2008-11-30 |
| HRP20070230B1 (en) | 2010-05-31 |
| WO2008142460A3 (en) | 2009-01-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Mesías et al. | Melanoidins as a potential functional food ingredient | |
| AU2003228245B2 (en) | Chewable compositions containing a gel-forming extract of psyllium | |
| KR20090018031A (en) | Guava leaf extract powder and preparation method thereof | |
| CN105707873A (en) | Health-care product composition containing procyanidine and preparation method of health-care product composition | |
| JP2008507486A (en) | Bioactive composition | |
| CN101258879A (en) | Aloe milk tablet | |
| CN103431098A (en) | Method for preparing okra tea lozenges | |
| WO2008142460A2 (en) | New herbal composition for prevention and treatmant of diabetes melitusa of type (i) and type (ii) | |
| Wang et al. | Effects of Eucommia ulmoides Oliver leaves on gut microbiota and intestinal function during in vitro simulated digestion and fermentation | |
| KR100509656B1 (en) | Sulfur eliminated noxious ingredient and producing method thereof | |
| JP2010178627A (en) | Food and drink | |
| Salleh et al. | The scavenging activity of encapsulated EBN hydrolysates using different combinations of polysaccharides as wall material by spray drying | |
| KR101808586B1 (en) | Manufacturing method of high purity black garlic concentrate removed oils extracts | |
| CN118787723A (en) | Anti-aging composition containing collagen and preparation method thereof | |
| JP5921151B2 (en) | Hyaluronidase activity inhibitor | |
| JP7228184B2 (en) | Eating and drinking composition | |
| KR101109756B1 (en) | Method for production of fermented composition using guava leaf powder | |
| JP2010254594A (en) | Intestinal Bacteroides growth promoter | |
| CN113498838B (en) | Honey-refined dried orange peel and citrus juice paste and preparation method thereof | |
| WO2014090569A1 (en) | Edible composition comprising an extract of inula racemosa and naringin | |
| KR101813200B1 (en) | MANUFACTURING METHOD OF BLACK GARLIC TABLET COMPRISING HIGH-CONTENT S-allylcysteine INCLUDING PINE NEEDLE | |
| Herdyastuti et al. | Evaluation of antioxidant activity, phenolic and vitamin C content of effect drying temperature in black garlic Kating type | |
| JP4502533B2 (en) | A method for producing an apple fiber stock solution, a method for producing a modified pectin powder using the stock solution, and a drink using the apple fiber stock solution. | |
| JP2006115810A (en) | Health food of onion husk powder for water extraction | |
| KR20050102320A (en) | Method for preparing composite flavoring materials of garlic bamboo salt or garlic salt |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 08737280 Country of ref document: EP Kind code of ref document: A2 |
|
| DPE1 | Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101) | ||
| DPE1 | Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101) | ||
| DPE1 | Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101) | ||
| NENP | Non-entry into the national phase |
Ref country code: DE |
|
| 122 | Ep: pct application non-entry in european phase |
Ref document number: 08737280 Country of ref document: EP Kind code of ref document: A2 |