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WO2008142015A2 - Distributeur et procédé de fonctionnement d'un distributeur - Google Patents

Distributeur et procédé de fonctionnement d'un distributeur Download PDF

Info

Publication number
WO2008142015A2
WO2008142015A2 PCT/EP2008/056017 EP2008056017W WO2008142015A2 WO 2008142015 A2 WO2008142015 A2 WO 2008142015A2 EP 2008056017 W EP2008056017 W EP 2008056017W WO 2008142015 A2 WO2008142015 A2 WO 2008142015A2
Authority
WO
WIPO (PCT)
Prior art keywords
container
dispenser
flow path
shaking
dispensing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/056017
Other languages
English (en)
Other versions
WO2008142015A3 (fr
Inventor
Søren SØRENSEN
Søren Vestergaard JACOBSEN
Bjørn Knud ANDERSEN
Søren Christrup
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phillips Medisize AS
Original Assignee
Bang and Olufsen Medicom AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bang and Olufsen Medicom AS filed Critical Bang and Olufsen Medicom AS
Publication of WO2008142015A2 publication Critical patent/WO2008142015A2/fr
Publication of WO2008142015A3 publication Critical patent/WO2008142015A3/fr
Anticipated expiration legal-status Critical
Priority to ZA2010/02729A priority Critical patent/ZA201002729B/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/0081—Locking means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0096—Hindering inhalation before activation of the dispenser

Definitions

  • the present invention relates to a dispenser and a method of operating a dispenser, and in particular a dispenser/method in which dispensing may be locked for one of a large number of reasons.
  • Dispensers adapted to control dispensing are known, which adapters normally comprise a container holding the drug/substance and a biasing means, typically a spring, for compressing the container. Such dispensers have means for either preventing the spring from being biased in the first place or which take up the biasing force of the spring until dispensing is desired.
  • a dispenser of that type may be seen in US-A-5, 692,492.
  • the invention relates to a breath actuated dispenser comprising:
  • a container holding a substance to be dispensed the container having an output adapted to dispense the substance into the flow path, the container being adapted to dispense the substance due to a compression thereof, biasing means for compressing the container, - retaining means for preventing compression of the container, the retaining means being movable between a first position, in which compression of the container is prevented, and a second position, in which compression of the container is allowed, force generating means positioned in the flow path and being adapted to generate a force from a gas flow in the flow path, the generating means being adapted to apply the force in order to allow the retaining means to move from its first position to the second position,
  • the dispenser further comprising locking means operative to prevent the force generating means from applying the force and/or the retaining means from moving from its first position to its second position.
  • the flow path is a path in the dispenser in which gas flows during inhalation.
  • This path may or may not be a specifically created path, such as a channel or tube, or may simply be openings and the like in the dispenser in/through which gas may flow, when the person inhales from the inhaler.
  • this flow path extends inside a housing of the dispenser, but the flow path may additionally be formed of other elements, such as the container etc.
  • any type of substance may be dispensed by an inhaler, such as medical substances, such as broncho and/or bronchiodilating substances or insulin.
  • medical substances such as broncho and/or bronchiodilating substances or insulin.
  • broncho and/or bronchiodilating substances or insulin a large number of other types of medications are presently inhaled, and research is carried out in order to formulate additional medications so as to be inhalable.
  • the dispensing of the container may be performed in any of a number of manners.
  • the substance may be output as a jet of a mixture of the substance and a carrier liquid, which jet is required in order to provide the substance as microscopic droplets or separated particles of a powder.
  • Another type of dispensing is the outputting of a powder, by itself or with a carrier liquid.
  • the powder may be output as a high velocity jet or may simply be positioned on a suitable surface in the flow path, where the flow generated may then "pick up" the powder and transfer it to the user.
  • the biasing is the providing of a force directed in a direction of desired compression of the container.
  • This compression normally is the displacement of one part of the container in a direction toward other parts of the container.
  • a deformation is not required.
  • Standard containers for dispensing powder or fluid substances comprise a dispensing stud and an internal biasing spring biasing the stud outwardly. Depression of the stud inwardly against the biasing (thus compressing the container) will facilitate dispensing.
  • the force may be dependent on the flow in the flow channel and may not be applied before a predetermined minimum flow is present. This may be obtained by requiring a certain minimum force, before this may be applied.
  • One type of generating means may be means movable or displaceable/rotatable by the gas flow, whereby the force may be generated.
  • Other types of generating means may be means adapted to generate power from the gas flow, which power is provided to an actuator thereby generating the force.
  • An embodiment incorporating a generating means of the first type is one, wherein the force generating means comprises obstructing means for obstructing the flow path, the obstructing means being adapted to move between a first position, in which the obstructing means obstructs the flow path and prevents the retaining means from moving to its second position, and a second position, in which the obstructing means does not obstruct the flow path to any substantial degree, the obstructing means allowing, in its second position, the retaining means to move to its second position. Movement from the first to the second position normally is at least partly in the direction of the flow.
  • the obstructing means need not fully close the flow path. It is fully sufficient to limit the flow there through sufficiently for the gas flow to actually move the obstructing means from its first to the second position, such as when the flow has a desired size.
  • the obstructing means and the retaining means may be formed by a rotatable element having two parts extending from an axis of rotation, the rotatable element having:
  • a first rotational position in which a first of the two parts extends into the flow channel and forms the obstructing means in its first position, and the other part forms the retaining means in its first position by extending from the axis of rotation in a direction being at an angle to a direction perpendicular to that of the biasing force (normally in a direction at least partly opposite to the biasing direction) exerted by the biasing means, and abutting the container and/or biasing means,
  • the locking means when operated, preferably engages the rotatable element and prevents it from rotating from the first to the second rotational position.
  • An interesting embodiment is one which further comprises means for detecting movement or shaking of the dispenser. Movement or shaking of the dispenser may be interesting for a number of reasons. The most usual reason is encountered when the substance to be dispensed from the container is a suspension or emulsion, whereby it is desired to ensure sufficient mixing of the contents before dispensing or dosing the next dose. Further below, another reason is explained.
  • the locking means comprise means for determining a point in time of shaking of the dispenser and for operating the locking means when a predetermined period of time has elapsed after the period of time. This may be in order to ensure that no dispensing is made after a predetermined point in time, such as if the substance is a suspension/emulsion, the mixing of which is ensured by the shaking. After the predetermined period of time, the mixing may no longer be optimal or suitable.
  • the detecting means be adapted to quantify the shaking and determine whether the shaking fulfils predetermined requirements. This may be in order to ascertain that a mixing is sufficient. Thus, a too weak shaking or a shaking for a too short time may not ensure sufficient mixing.
  • Such requirements may be a minimum period of time during which the shaking (such as a minimum shaking) should take place.
  • the requirements may be related to the quality of the shaking, such as how vigorously the shaking is performed, for example a quantification of the accelerations performed or the velocities reached during the shaking. This may be both in a single dimension, two dimensions or even three dimensions (such as a combination of a linear/bent shaking and rotation).
  • determining means may be provided which are adapted to determine a point in time of shaking, such as where the shaking fulfils the predetermined requirements. Thus, shaking not fulfilling the requirements may then not be taken into account.
  • a preferred embodiment is one further comprising means for quantifying or estimating, on the basis of movement of the dispenser, a physical activity level of the user.
  • This activity level may be used for numerous purposes.
  • One purpose is the adaptation of a dispensing scheme (doses and points of time of dispensing) to the activity of the user. Certain drugs or substances are more quickly taken up by the body during activity, others are not need to the same degree during or due to the activity, and again others are desired/required due to the activity.
  • the quantification of the level of activity may be performed in any desired manner, such as on the basis of a period of time during which the person is active, accelerations/velocities/frequencies/distances obtained, a rise in skin temperature, a rise in pulse, or the like.
  • a particular pattern of such parameters may be recognized based on e.g. a predetermined training program, on the basis of which the activity level is also known.
  • insulin which is used by patients suffering from type I diabetes to facilitate transport of carbohydrates (sugar) into the cells.
  • carbohydrates sucgar
  • a larger level of activity requires the transport of more carbohydrates, whereby it may be desired to actually dispense more insulin and/or dispense insulin at shorter time intervals, if the user is more active than expected (such as when defining a dispensing scheme for the user).
  • bronchio/bronchia dilating substances such as ventoline
  • ventoline Another example is bronchio/bronchia dilating substances, such as ventoline, which may be desired during the activity in order to ensure that the user has sufficient breathing/lung capacity during the activity.
  • This adaptation of the dosing scheme may be determined in real time in order to be able to e.g. inform the user of when to take the next dose (especially if a different point in time than that according to the original dispensing scheme is determined).
  • This informing may be performed in any desired manner (visible, tactile, and/or audio information or the like).
  • the dose amount/quantity may be altered, which the user could also be made aware of.
  • these quantifying/estimating means are preferably adapted to perform the quantification/estimation on the basis of an output of the detecting means.
  • the detecting means may be used for both determining a presence/quality/quantity of a shaking of the container and may be used for determining the level of activity of the user.
  • the signals of the detecting means may be filtered etc. in order to separate e.g. the movement caused by the user running from the movement caused by the user shaking the container - or the user riding a car on a bumpy road (which may not be seen as shaking and/or activity at all).
  • the dispenser may further comprise means for determining a point in time of dispensing the substance.
  • This information may both be used for determining a next point in time of dispensing or for storing and for reading out for a physician or the like to analyze in order to check whether the user takes the substance in accordance with a dispensing scheme.
  • This information may also be used in a dispenser wherein the locking means comprise means for determining a point in time of dispensing substance and for operating the locking means according to a predetermined schedule incorporating the determined dispensing time(s).
  • the above detecting means may comprise any means adapted to detect a movement.
  • Standard movement/acceleration determining components are: an accelerometer, a gyrometer, a magnetic sensor, an inductive sensor, an optical sensor, a GPS sensor, a MEMS sensor, a piezo element, and a tilt sensor.
  • the retaining means mentioned above may be formed by any type of means able to prevent movement of another element, such as all types of actuators and motors having at least two positions (and which preferably use energy only when changing position), such as the motors used as vibrators in cell phones, linear magnetic actuators, such as a solenoid, bimetal springs, piezo actuators, or the like.
  • Another aspect of the invention relates to a method of operating a breath actuated dispenser, the method comprising:
  • step 4. comprises providing an obstructing means being adapted to move between a first position, in which the obstructing means obstructs the flow path, and a second position, in which the obstructing means does not obstruct the flow path to any substantial degree, positioning the obstructing means in the first position, and
  • step 5 comprises the obstructing means obstructing the flow in the flow path, and
  • step 6. comprises the flow moving the obstructing means from the first to the second position.
  • steps 3 and 4 may comprise providing the obstructing means and the retaining means as a rotatable element having two parts extending from an axis of rotation, and step 6. may then comprises rotating the rotatable element between:
  • a first rotational position in which a first of the two parts extends into the flow channel and forms the obstructing means in its first position, and the other part forms the retaining means in its first position by extending from the axis of rotation in a direction being at least substantially parallel to and opposite to a biasing force exerted by the biasing means, and abutting the container,
  • the step of operating the locking means in the first position could comprise the locking means engaging the rotatable element and preventing it from rotating from the first to the second rotational position.
  • a preferred embodiment comprises the step of identifying a shaking and/or movement of the dispenser.
  • the step of operating the locking means in its first position may comprise determining a point in time of shaking of the dispenser and operating the locking means in its first position when a predetermined period of time has elapsed after the point in time.
  • the identifying step preferably comprises quantifying the shaking and determining whether the shaking fulfils predetermined requirements.
  • the determining step could comprise determining a point in time of shaking, such as only if the predetermined requirements are fulfilled.
  • the predetermined point in time is determined on the basis of the quantified shaking.
  • the method could further comprise the step of quantifying or estimating, on the basis of movement of the dispenser, a physical activity level of the user.
  • the quantifying/estimating step could be performed on the basis of an output of the detecting means.
  • the method may comprise the step of determining a point in time of dispensing the substance.
  • the locking step could comprise determining a point in time of dispensing substance and operating the locking means according to a predetermined schedule incorporating the determined dispensing time(s).
  • both the activity determination and the points of time of dispensing may be used to correlate to or adapt a dispensing scheme of the user.
  • This dispensing scheme may be stored in the dispenser, and the dispenser may comprise means for informing the user of when to dispense and maybe even the dose to dispense, if the dispenser does not automatically adapt the dose.
  • a third aspect relates to a dispenser comprising:
  • a flow path for guiding air or gas for inhalation - a container holding a substance to be dispensed, the container having an output adapted to dispense the substance into the flow path, means for facilitating a dispensing from the container, retaining means for preventing dispensing, movement detecting means adapted to detect movement of the dispenser and/or container, controlling means for determining, on the basis of the detected movement, a level of activity of the user.
  • this dispenser may be a breath actuated dispenser according to the first aspect.
  • a shaking of the dispenser/container may also be determined from the detected movement, and this may be used for operating the retaining means in its first position, until a sufficient shaking is detected.
  • the above-mentioned quantification/quality determination of the shaking may be used, as may the timing relationship where dispensing may be prevented for a predetermined period of time from shaking or from a point in time after the shaking, depending on the reason for preventing dispensing. Also, the manner of separating movement of the user and shaking of the dispenser/container may be trivial signal treatment/filtering.
  • the dispenser further comprises means for indicating to a user that substance should be inhaled, the indicating means being operated on the basis of an output of the activity determining means.
  • the point in time of indicating dispensing, or the time interval between two dispensings, to the user may be determined on the basis of the activity determined, as is described above. This may be an adaptation on the basis of the most recent activity or may be determined over a longer period of time.
  • the dispenser may further comprise means adapted to adapt a dose dispensed by the container, the adapting means being operated on the basis of an output of the activity determining means.
  • the point in time of dispensing may be unaltered and the dose adapted instead.
  • a combination may also be suitable. Multiple manners of adapting the dose are known.
  • the dispenser may comprise controlling means determining the activity and the shaking and determining dispensing times and/or dispensing doses and informing the user accordingly (or adapting the doses automatically).
  • a fourth aspect relates to a method of operating a dispenser having: a flow path for guiding air or gas for inhalation, a container holding a substance to be dispensed, the container having an output adapted to dispense the substance into the flow path, - means for facilitating dispensing from the container, and retaining means for preventing dispensing, the method comprising: detecting movement of the dispenser and/or container, and determining, on the basis of the detected movement, a level of activity of the user.
  • a shaking of the dispenser/container may be quantified on the basis of the detected movement and the retaining means may be operated in its first position, until a sufficient shaking is detected.
  • Thee method may further comprise the step of indicating to a user that substance should be inhaled, the indicating being performed on the basis of the determined level of activity.
  • the method may further comprise adapting a dose dispensed by the container, the adapting being performed on the basis of the determined level of activity.
  • Figure 1 illustrates a first embodiment of the dispenser in a loaded, locked state
  • Figure 2 illustrates the dispenser of figure 1 in a loaded, unlocked state
  • Figure 3 illustrates the dispenser of figure 1 during dispensing
  • Figure 4 illustrates another embodiment of a dispenser
  • Figure 5 illustrates a third embodiment of a dispenser according to the invention.
  • dispenser 10 is seen having a housing 12, in which a container 14 is present in the shape of a pressurized canister which, when compressed (see further below), will dispense a dose of a drug.
  • the container 14 is biased, by a spring 16, toward a holding element 18, which is movable in a vertical direction.
  • the holding element 18 In figure 1, the holding element 18 is in an upper position, and in figure 3, it is in a lower state.
  • the container 14 has a tip or output 19, which is received in a mouth piece 20 which is adapted to receive the dosed drug and forward it to the mouth of the user.
  • the mouth piece 20 is adapted to engage the tip 19 so that, when the holding element 18 is in the lower position, the tip 19 is forced into the container 14 (the container is compressed along that direction), in order to obtain the dosing of the drug.
  • the arm 32 counteracts the force exerted by the spring 16, as it transfers this force to the axis 30, which takes up this force.
  • the arm 34 blocks or obstructs a flow path F through which air will pass from outside the dispenser 10 to the mouth piece 20 during inhaling of the user. Inhaling will cause a flow which will exert a force on the arm 34, and if the inhalation is sufficiently strong, the force exerted will result in a rotation of the element 28, which again will remove the counteraction of the force exerted by the spring 16, whereby compression of the container 14 will be possible. This resulting action and position may be seen in figure 3.
  • a blocking/locking means 37 is provided, which prevents rotation of the element 28 due to inhalation/flow.
  • This blocking means 37 engages the arm 32 from the side toward which the arm 32 would move during rotation.
  • the blocking means 40 thus prevents dispensing.
  • the blocking means 37 may be made much smaller and simpler than known blocking means which must block the force exerted by the spring 16.
  • the blocking means 37 comprises a stationary part and a moving part, the stationary part comprising a solenoid/coil, and the moving part comprising a magnet or magnetic material.
  • any other manner of blocking the arm 32 may be used, and the same blocking action may be obtained by blocking the arm 34 or the rotation around the axis 30.
  • a simple manner is simply that of preventing dispensing of a drug for a predetermined period of time since a previous dispensing.
  • Dispensing may be detected in a number of manners, one being a sensor sensing the compression of the container 14. Another sensor type is a detector sensing vibrations or sound generated by the dispensing of the drug. Further sensor types may detect the presence of drug in the mouth piece or flow in the flow channel.
  • Another strategy of preventing dispensing of the drug may be one combined with a dispensing scheme in which preferred points in time of dispensing are provided together with time windows or intervals in which dispensing is or is not allowed.
  • the container 14 may be desirable to be able to determine whether the container 14 has been shaken before dispensing.
  • a carrier liquid i.e. an emulsion or a suspension
  • Such containers 14 may have an internal dosing chamber in which the next dose of the drug and carrier liquid is dosed. In that situation, it will be desirable to ensure that the drug and liquid in the container is sufficiently mixed upon dosing.
  • a number of different types of sensor may be used for sensing shaking or mixing of the contents of the container 14, such as accelerometers (2-dimensional or 3-dimensional as may be found in airbags or pedometers), piezo elements, capacitive sensors, electrolytic tilt sensors (where e.g. a resistive liquid partly connects electrodes resulting in a resistor value indicating inclination).
  • accelerometers (2-dimensional or 3-dimensional as may be found in airbags or pedometers
  • piezo elements piezo elements
  • capacitive sensors capacitive sensors
  • electrolytic tilt sensors where e.g. a resistive liquid partly connects electrodes resulting in a resistor value indicating inclination).
  • the amount of shaking or mixing required will depend on the drug and carrier liquid, or other combination of substances which are required to be mixed, and routine testing is performed in order to determine for how long or how vigorously the shaking should be.
  • the blocking means 37 may be actuated to block dispensing, until the mixing/shaking is sufficient. In this respect, it should be noted that the dosing of the next dose need not be at the time of dispensing of a dose.
  • the container 14 may be of a type in which the dosing takes place when the container 14 is again released and not at the time of compression. This may be taken into account in the dispenser.
  • this sensor may be used also for other purposes.
  • One such purpose may be to quantify the physical activity of the user.
  • Physical activity may be determined on the basis of a frequency or signal analysis of a signal from the detector. This signal may be filtered in order to determine the type of exercise and remove signals not related to exercise, such as the bumping caused by a car on a bumpy road. Other types of sensors may be added to determine the physical activity, such as GPS- sensors, pulse sensors, breath sensors, or the like.
  • this may be relevant for drugs affected by or affecting the metabolism of the person, such as persons taking growth hormone or hormones affecting the metabolism, such as steroid hormones (such as adrenal cortex hormone, growth hormone, and heart medicine, such as digitalis glycosides (e.g. nitro glycerine).
  • drugs affected by or affecting the metabolism of the person such as persons taking growth hormone or hormones affecting the metabolism, such as steroid hormones (such as adrenal cortex hormone, growth hormone, and heart medicine, such as digitalis glycosides (e.g. nitro glycerine).
  • steroid hormones such as adrenal cortex hormone, growth hormone, and heart medicine, such as digitalis glycosides (e.g. nitro glycerine).
  • drugs broken down in the liver in that heavy physical activity may shut of or reduce the blood flow to the liver and the intestines. Thus, great physical activity may reduce the breaking down of drugs to be broken down in the liver.
  • bronchio dilating drug For persons suffering from asthma, it may be relevant to allow dispensing of a bronchio dilating drug more often, if the person is physically active.
  • the dispenser may additionally comprise means for determining a drug dose to dispense and/or means for notifying the user that a dose should be taken in accordance with a, such as a revised, dispensing scheme.
  • the revision of this dispensing scheme may depend heavily on the amount of the activity.
  • Routine testing may be performed in order to determine this adaptation of the dispensing scheme.
  • a container 14 comprising a drug and a carrier liquid
  • This need not be a pressurized dispensing, and in fact, the container 14 may be replaced by e.g. a blister card from which a powder or liquid from a blister is guided to the gas flow path for inhalation.
  • Figure 4 illustrates another embodiment again using the dispenser 14 with the tip 19 and biased by a spring 16.
  • a yoke 38 is provided between the spring 16 and the container 14, and is additionally engaged a first arm 42 of a lever 39 comprising another arm 44 and being rotatable about an axis 40. This lever prevents downward movement of the yoke 38 and thereby compression of the container 14.
  • the lever 39 is prevented from rotating counter clockwise by an arm 52 of a lever 51 comprising also another arm 54 and being rotatable around an axis 50. It is seen that as long as the lever 51 cannot be rotated, upward movement of the arm 44 and thereby downward movement of the yoke 38 is not allowed.
  • the lever 51 is connected, via a rotatable engagement 58, to an arm 56 engaging a rotatable element 62 connected to a flap 60.
  • the flap 60 is positioned in the flow path of the inhaler, and the operation of the inhaler dispensing mechanism is as follows:
  • FIG 4 is also illustrated a number of positions A), B), C), D), which all are useful for blocking the above dispensing, if this dispensing is not desired or allowed.
  • These positions require, contrary to the position E), a force much lower than that exerted by the spring 16, in order to prevent dispensing.
  • These forces may easily be calculated by the spring force of the spring 16 and the force required or provided by inhalation and via the flap 60 as well as the individual distances and angles.
  • Figure 5 illustrates an alternative to the embodiment of figure 4, wherein the rather complex interaction of the arms 54, 56, the flap 60, the element 62 and the joint 58 are simply replaced by the flap 54.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Nozzles (AREA)

Abstract

L'invention concerne un distributeur actionné par la respiration dans lequel la force issue de l'écoulement d'un gaz est utilisée pour permettre la distribution d'une dose, et comprenant en outre des moyens de verrouillage aptes à empêcher la force de permettre la distribution. Ainsi, un verrouillage peut être effectué à l'aide d'une force bien inférieure. De plus, le distributeur a des moyens de détection de mouvement aptes à déterminer un degré d'activité physique d'un utilisateur.
PCT/EP2008/056017 2007-05-18 2008-05-16 Distributeur et procédé de fonctionnement d'un distributeur Ceased WO2008142015A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ZA2010/02729A ZA201002729B (en) 2007-11-29 2010-04-19 Laundry product

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92451107P 2007-05-18 2007-05-18
US60/924,511 2007-05-18

Publications (2)

Publication Number Publication Date
WO2008142015A2 true WO2008142015A2 (fr) 2008-11-27
WO2008142015A3 WO2008142015A3 (fr) 2009-03-05

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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010003846A1 (fr) * 2008-07-10 2010-01-14 Bang & Olufsen Medicom A/S Inhalateur et son procédé de fonctionnement
GB2469068A (en) * 2009-03-31 2010-10-06 Naseem Bari A counter with motion sensor
WO2011114355A1 (fr) * 2010-03-17 2011-09-22 Sun Pharma Advanced Research Company Ltd. Aérosol-doseur
WO2011157561A1 (fr) * 2010-06-18 2011-12-22 Boehringer Ingelheim International Gmbh Inhalateur
DE102011007008A1 (de) * 2011-04-07 2012-10-11 Ing. Erich Pfeiffer Gmbh Medienspender
US8807131B1 (en) 2013-06-18 2014-08-19 Isonea Limited Compliance monitoring for asthma inhalers
WO2020015943A1 (fr) * 2018-07-16 2020-01-23 Alfred Von Schuckmann Appareil à main de distribution en portions de substances pulvérisables
EP3508082B1 (fr) 2010-08-24 2020-06-10 JT International S.A. Dispositif d'inhalation comprenant des commandes d'usage de substance
CN111405919A (zh) * 2017-10-18 2020-07-10 阿普塔尔法国简易股份公司 与吸入同步分配流体产品的流体产品分配装置
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EP3508082B1 (fr) 2010-08-24 2020-06-10 JT International S.A. Dispositif d'inhalation comprenant des commandes d'usage de substance
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US11701482B2 (en) 2012-10-19 2023-07-18 Nicoventures Trading Limited Electronic inhalation device
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US11116254B2 (en) 2013-10-09 2021-09-14 Nicoventures Trading Limited Power regulation system and method of supplying power to an electronic vapor provision system
US10945463B2 (en) 2015-07-01 2021-03-16 Nicoventures Holdings Limited Electronic aerosol provision system with multiple modes based on sensed events
US11752284B2 (en) 2015-07-01 2023-09-12 Nicoventures Trading Limited Electronic aerosol provision system with motion sensing
CN111405919B (zh) * 2017-10-18 2022-03-29 阿普塔尔法国简易股份公司 与吸入同步分配流体产品的流体产品分配装置
CN111405919A (zh) * 2017-10-18 2020-07-10 阿普塔尔法国简易股份公司 与吸入同步分配流体产品的流体产品分配装置
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