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WO2008140782A3 - Composés d'inhibition enzymatique - Google Patents

Composés d'inhibition enzymatique Download PDF

Info

Publication number
WO2008140782A3
WO2008140782A3 PCT/US2008/005997 US2008005997W WO2008140782A3 WO 2008140782 A3 WO2008140782 A3 WO 2008140782A3 US 2008005997 W US2008005997 W US 2008005997W WO 2008140782 A3 WO2008140782 A3 WO 2008140782A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
based compounds
compounds
enzyme inhibition
proteasome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/005997
Other languages
English (en)
Other versions
WO2008140782A2 (fr
Inventor
Han-Jie Zhou
Guy J Laidig
Kevin D Shenk
Congcong M Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Onyx Pharmaceuticals Inc
Original Assignee
Proteolix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proteolix Inc filed Critical Proteolix Inc
Publication of WO2008140782A2 publication Critical patent/WO2008140782A2/fr
Publication of WO2008140782A3 publication Critical patent/WO2008140782A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des composés à base de peptides comprenant des noyaux à trois chaînons contenant des hétéroatomes, qui inhibent de manière efficace et sélective des activités spécifiques de N-terminal nucléophile (Ntn) hydrolases associées au protéasome. Ces composés à base de peptides comprennent un époxide ou une aziridine, et une fonctionnalisation à l'extrémité N. Entre autres applications thérapeutiques, les composés à base de peptides peuvent présenter des propriétés anti-inflammatoires et d'inhibition de la prolifération cellulaire. L'administration par voie orale de ces inhibiteurs de protéasome à base de peptides est possible en raison de leur profil de biodisponibilité.
PCT/US2008/005997 2007-05-10 2008-05-09 Composés d'inhibition enzymatique Ceased WO2008140782A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92875807P 2007-05-10 2007-05-10
US60/928,758 2007-05-10

Publications (2)

Publication Number Publication Date
WO2008140782A2 WO2008140782A2 (fr) 2008-11-20
WO2008140782A3 true WO2008140782A3 (fr) 2008-12-31

Family

ID=39743821

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/005997 Ceased WO2008140782A2 (fr) 2007-05-10 2008-05-09 Composés d'inhibition enzymatique

Country Status (1)

Country Link
WO (1) WO2008140782A2 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102174076A (zh) 2004-04-15 2011-09-07 普罗特奥里克斯公司 用于抑制蛋白酶体酶的化合物
US8198270B2 (en) 2004-04-15 2012-06-12 Onyx Therapeutics, Inc. Compounds for proteasome enzyme inhibition
SG185963A1 (en) 2004-05-10 2012-12-28 Onyx Therapeutics Inc Compounds for enzyme inhibition
LT2623113T (lt) 2005-11-09 2017-07-10 Onyx Therapeutics, Inc. Junginiai, skirti fermentų slopinimui
PL2041158T3 (pl) 2006-06-19 2013-08-30 Onyx Therapeutics Inc Peptydowe epoksyketony do hamowania proteasomu
ES2684340T3 (es) 2007-10-04 2018-10-02 Onyx Therapeutics, Inc. Inhibidores de proteasa epoxi cetona de péptidos cristalinos y síntesis de cetoepóxidos de aminoácidos
US7635773B2 (en) 2008-04-28 2009-12-22 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions
EP2349313A4 (fr) 2008-10-21 2012-08-29 Onyx Therapeutics Inc Thérapie de combinaison avec des peptides époxycétones
UA107569C2 (xx) * 2009-03-20 2015-01-26 Кристалічні трипептидні інгібітори епоксикетонпротеази
AU2013203857B2 (en) * 2009-03-20 2016-05-19 Onyx Therapeutics, Inc. Crystalline tripeptide epoxy ketone protease inhibitors
TWI504598B (zh) * 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
WO2011060179A1 (fr) 2009-11-13 2011-05-19 Onyx Therapeutics, Inc Utilisation de peptides epoxycetones pour la suppression de la metastase
EA201290844A1 (ru) 2010-03-01 2013-03-29 Оникс Терапьютикс, Инк. Соединения для ингибирования иммунопротеасом
PL2814849T3 (pl) 2012-02-15 2020-07-27 Cydex Pharmaceuticals, Inc. Sposób wytwarzania pochodnych cyklodekstryny
US20140105921A1 (en) 2012-07-09 2014-04-17 Onyx Therapeutics, Inc. Prodrugs of Peptide Epoxy Ketone Protease Inhibitors
CN103570806B (zh) * 2012-07-26 2020-04-07 圣特莱国际公司 多肽环氧酮化合物
HK1213585A1 (zh) 2012-10-22 2016-07-08 Cydex Pharmaceuticals, Inc. 烷基化环糊精组合物及其制备和使用方法
TW201422255A (zh) 2012-10-24 2014-06-16 Onyx Therapeutics Inc 用於蛋白酶體抑制劑之調整釋放製劑
KR102360356B1 (ko) 2014-07-14 2022-02-08 센트랙스 인터내셔널, 아이엔씨. 효소 억제를 위한 에폭시케톤 화합물
FI3183295T3 (fi) 2014-08-22 2023-09-25 Cydex Pharmaceuticals Inc Fraktioidut alkyloidut syklodekstriinikoostumukset ja menetelmät niiden valmistamiseksi ja käyttämiseksi
CN105949279A (zh) * 2016-04-27 2016-09-21 浙江大学 蛋白酶体抑制剂Oprozomib及其类似物的制备方法
CN110092813B (zh) * 2019-06-05 2021-05-11 南京师范大学 一种三肽环氧丙烷衍生物及其制备方法和用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005111008A2 (fr) * 2004-05-10 2005-11-24 Proteolix, Inc. Composes d'inhibition enzymatique
WO2006045066A2 (fr) * 2004-10-20 2006-04-27 Proteolix, Inc. Composes pour inhibition d'enzymes
WO2007056464A1 (fr) * 2005-11-09 2007-05-18 Proteolix, Inc. Composés pour l'inhibition d'enzymes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005111008A2 (fr) * 2004-05-10 2005-11-24 Proteolix, Inc. Composes d'inhibition enzymatique
WO2006045066A2 (fr) * 2004-10-20 2006-04-27 Proteolix, Inc. Composes pour inhibition d'enzymes
WO2007056464A1 (fr) * 2005-11-09 2007-05-18 Proteolix, Inc. Composés pour l'inhibition d'enzymes

Also Published As

Publication number Publication date
WO2008140782A2 (fr) 2008-11-20

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