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WO2008140598A3 - Novel immunotherapeutic mycobacteria, pharmaceutic formulations and uses thereof - Google Patents

Novel immunotherapeutic mycobacteria, pharmaceutic formulations and uses thereof Download PDF

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Publication number
WO2008140598A3
WO2008140598A3 PCT/US2007/086335 US2007086335W WO2008140598A3 WO 2008140598 A3 WO2008140598 A3 WO 2008140598A3 US 2007086335 W US2007086335 W US 2007086335W WO 2008140598 A3 WO2008140598 A3 WO 2008140598A3
Authority
WO
WIPO (PCT)
Prior art keywords
mycobacterium strains
mycobacteria
pharmaceutic
methods
genetically modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/086335
Other languages
French (fr)
Other versions
WO2008140598A2 (en
Inventor
David M. Hone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bacilligen Inc
Original Assignee
Bacilligen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bacilligen Inc filed Critical Bacilligen Inc
Publication of WO2008140598A2 publication Critical patent/WO2008140598A2/en
Anticipated expiration legal-status Critical
Publication of WO2008140598A3 publication Critical patent/WO2008140598A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

This invention provides genetically modified Mycobacterium strains that are useful as an anticancer immunotherapeutic. The genetically modified Mycobacterium strains preferably display at least one genetic modification resulting in increased tissue adherence, which can be combined with genetic modifications that increase immunopotency and result in adjuvant production. The invention also provides compositions and methods for the development of said Mycobacterium strains, and pharmaceutic compositions and methods for the use of said Mycobacterium strains as anticancer therapeutics.
PCT/US2007/086335 2006-12-04 2007-12-04 Novel immunotherapeutic mycobacteria, pharmaceutic formulations and uses thereof Ceased WO2008140598A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86845006P 2006-12-04 2006-12-04
US60/868,450 2006-12-04

Publications (2)

Publication Number Publication Date
WO2008140598A2 WO2008140598A2 (en) 2008-11-20
WO2008140598A3 true WO2008140598A3 (en) 2016-06-09

Family

ID=40002815

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/086335 Ceased WO2008140598A2 (en) 2006-12-04 2007-12-04 Novel immunotherapeutic mycobacteria, pharmaceutic formulations and uses thereof

Country Status (1)

Country Link
WO (1) WO2008140598A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
JP2012514476A (en) * 2009-01-08 2012-06-28 アルバート アインシュタイン カレッジ オブ メディシン オブ イェシバ ユニバーシティ，ア ディビジョン オブ イェシバ ユニバーシティ Bacterial vaccine with cell wall-bound ceramide-like glycolipid and use thereof
US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
US12359209B2 (en) 2018-04-17 2025-07-15 The Johns Hopkins Unversity Recombinant therapeutic interventions for cancer
US20210024940A1 (en) * 2018-04-17 2021-01-28 The Johns Hopkins University Recombinant therapeutic interventions for cancer
JP2024512499A (en) * 2021-03-22 2024-03-19 クリップスビーエヌシー・カンパニー・リミテッド Novel recombinant Mycobacterium smegmatis strains and their uses
EP4477226A1 (en) * 2022-02-11 2024-12-18 Instituto Butantan Compositions comprising recombinant strains of mycobacterium, uses thereof and methods for the prevention and/or treatment of cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050220811A1 (en) * 2002-04-05 2005-10-06 Stewart Cole Identification of virulence associated regions rd1 and rd5 leading to improve vaccine of m. bovis bcg and m. microti
EP1882741A1 (en) * 2006-07-25 2008-01-30 Institut Pasteur Recombinant Mycobacterium strain expressing a mycobacterial FAP protein under the control of a promoter active under hypoxia and its application for cancer therapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050220811A1 (en) * 2002-04-05 2005-10-06 Stewart Cole Identification of virulence associated regions rd1 and rd5 leading to improve vaccine of m. bovis bcg and m. microti
EP1882741A1 (en) * 2006-07-25 2008-01-30 Institut Pasteur Recombinant Mycobacterium strain expressing a mycobacterial FAP protein under the control of a promoter active under hypoxia and its application for cancer therapy

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
LEWIS ET AL.: "Deletion of RD1 from Mycobacterium tuberculosis Mimics Bacille Calmette-Guerin Attenuation.", JOURNAL OF INFECTIOUS DISEASES, vol. 187, no. 1, 2003, pages 117 - 23, XP002987276, DOI: doi:10.1086/345862 *
MIYAMOTO ET AL.: "Aggregation of mycobacteria caused by disruption of fibronectin-attachment protein-encoding gene .", FEMS MICROBIOLOGY LETTERS, vol. 236, no. 2, 2004, pages 227 - 234 *
SECOTT ET AL.: "Fibronectin Attachment Protein Is Necessary for Efficient Attachment and Invasion of Epithelial Cells by Mycobacterium avium subsp. paratuberculosis.", INFECTION AND IMMUNITY, vol. 70, no. 5, May 2002 (2002-05-01), pages 2670 - 2675 *
ZHAO ET AL.: "Characterization of the Fibronectin Binding Motif for a Unique Mycobacterial Fibronectin Attachment Protein, FAP.", J. BIOL CHEM, vol. 274, no. 8, 19 February 1999 (1999-02-19), pages 4521 - 4526 *
ZHAO ET AL.: "ROLE OF A BACILLUS CALMETTE-GUERIN FIBRONECTIN ATTACHMENT PROTEIN IN BCG-INDUCED ANTITUMOR ACTIVITY.", INT. J. CANCER, vol. 86, no. 1, 2000, pages 83 - 88, XP002401487, DOI: doi:10.1002/(SICI)1097-0215(20000401)86:1<83::AID-IJC13>3.0.CO;2-R *

Also Published As

Publication number Publication date
WO2008140598A2 (en) 2008-11-20

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