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WO2008140420A3 - Dérivés de pyrimidine - Google Patents

Dérivés de pyrimidine Download PDF

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Publication number
WO2008140420A3
WO2008140420A3 PCT/SG2008/000179 SG2008000179W WO2008140420A3 WO 2008140420 A3 WO2008140420 A3 WO 2008140420A3 SG 2008000179 W SG2008000179 W SG 2008000179W WO 2008140420 A3 WO2008140420 A3 WO 2008140420A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
disorders
treatment
pyrimidine derivatives
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/SG2008/000179
Other languages
English (en)
Other versions
WO2008140420A2 (fr
Inventor
Haishan Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SBio Pte Ltd
Original Assignee
SBio Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SBio Pte Ltd filed Critical SBio Pte Ltd
Publication of WO2008140420A2 publication Critical patent/WO2008140420A2/fr
Publication of WO2008140420A3 publication Critical patent/WO2008140420A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D515/18—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des composés de pyrimidine utilisés comme agents dans le traitement de troubles associés aux kinases, tels que des troubles de prolifération. La présente invention concerne, plus particulièrement, des composés de pyrimidine substitués, leurs procédé de préparation, des compositions pharmaceutiques contenant lesdits composés et les utilisations de ces composés dans le traitement de troubles de prolifération. Ces composés peuvent être utilisés comme médicaments dans le traitement d'un certain nombre de troubles associés aux kinases tels que des troubles de prolifération, y compris des tumeurs et des cancers, ainsi que d'autres troubles ou états pathologiques associés aux kinases.
PCT/SG2008/000179 2007-05-15 2008-05-14 Dérivés de pyrimidine Ceased WO2008140420A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92444307P 2007-05-15 2007-05-15
US60/924,443 2007-05-15

Publications (2)

Publication Number Publication Date
WO2008140420A2 WO2008140420A2 (fr) 2008-11-20
WO2008140420A3 true WO2008140420A3 (fr) 2009-04-30

Family

ID=40002773

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SG2008/000179 Ceased WO2008140420A2 (fr) 2007-05-15 2008-05-14 Dérivés de pyrimidine

Country Status (1)

Country Link
WO (1) WO2008140420A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3001085A1 (fr) * 2015-10-08 2017-04-13 Bayer Pharma Aktiengesellschaft Nouveaux composes macrocycliques modifies
US11254690B2 (en) 2017-03-28 2022-02-22 Bayer Pharma Aktiengesellschaft PTEFb inhibiting macrocyclic compounds
EP3601236A1 (fr) 2017-03-28 2020-02-05 Bayer Aktiengesellschaft Nouveaux composés macrocycliques inhibiteurs de ptefb
CN117964628A (zh) * 2022-10-24 2024-05-03 科辉智药生物科技(深圳)有限公司 作为cdk9抑制剂的大环类化合物及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078682A2 (fr) * 2003-03-05 2004-09-16 Irm Llc Composes cycliques et compositions servant d'inhibiteurs de proteines-kinases
WO2007058628A1 (fr) * 2005-11-16 2007-05-24 S*Bio Pte Ltd Derives de pyrimidine a liaison heteroalkyle

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078682A2 (fr) * 2003-03-05 2004-09-16 Irm Llc Composes cycliques et compositions servant d'inhibiteurs de proteines-kinases
WO2007058628A1 (fr) * 2005-11-16 2007-05-24 S*Bio Pte Ltd Derives de pyrimidine a liaison heteroalkyle

Also Published As

Publication number Publication date
WO2008140420A2 (fr) 2008-11-20

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