[go: up one dir, main page]

WO2008140111A1 - シンナミド誘導体のワンポット製造方法 - Google Patents

シンナミド誘導体のワンポット製造方法 Download PDF

Info

Publication number
WO2008140111A1
WO2008140111A1 PCT/JP2008/058902 JP2008058902W WO2008140111A1 WO 2008140111 A1 WO2008140111 A1 WO 2008140111A1 JP 2008058902 W JP2008058902 W JP 2008058902W WO 2008140111 A1 WO2008140111 A1 WO 2008140111A1
Authority
WO
WIPO (PCT)
Prior art keywords
production process
formula
pot production
cinnamide derivative
pot
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/058902
Other languages
English (en)
French (fr)
Inventor
Naoyuki Shimomura
Seiji Yoshikawa
Yoshihiko Hisatake
Akio Imai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai R&D Management Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Management Co Ltd filed Critical Eisai R&D Management Co Ltd
Priority to AU2008250119A priority Critical patent/AU2008250119A1/en
Priority to EP08752763A priority patent/EP2147917A4/en
Priority to CN200880016336A priority patent/CN101679360A/zh
Priority to JP2009514176A priority patent/JPWO2008140111A1/ja
Priority to CA002687262A priority patent/CA2687262A1/en
Publication of WO2008140111A1 publication Critical patent/WO2008140111A1/ja
Priority to IL202098A priority patent/IL202098A0/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

　塩基の存在下、式（２） （式中、Ｒ１は４－フルオロフェニル基などを示し、Ｑは－ＣＨ（ＣＨ３）－などを示し、ｎは１などを示す）で表される化合物と３－メトキシ－４－（４－メチル－１Ｈ－イミダゾール－１－イル）ベンズアルデヒドとを反応させ、要すれば、保護基を除去することにより、式（１） （式中、Ｒは４－フルオロフェニル基などを示し、Ｑおよびｎは、前記定義と同意義を示す）で表される化合物またはその医薬上許容される塩をワンポットで製造することができる。
PCT/JP2008/058902 2007-05-16 2008-05-15 シンナミド誘導体のワンポット製造方法 Ceased WO2008140111A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2008250119A AU2008250119A1 (en) 2007-05-16 2008-05-15 One-pot production process for cinnamide derivative
EP08752763A EP2147917A4 (en) 2007-05-16 2008-05-15 EINTOPF PRODUCTION PROCESS FOR CINEMA ACID AMID DERIVATIVE
CN200880016336A CN101679360A (zh) 2007-05-16 2008-05-15 一步生产肉桂酰胺衍生物的方法
JP2009514176A JPWO2008140111A1 (ja) 2007-05-16 2008-05-15 シンナミド誘導体のワンポット製造方法
CA002687262A CA2687262A1 (en) 2007-05-16 2008-05-15 One-pot production process for cinnamide derivative
IL202098A IL202098A0 (en) 2007-05-16 2009-11-12 One-pot production process for cinnamide derivative

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US93834907P 2007-05-16 2007-05-16
US60/938349 2007-05-16
JP2007-130134 2007-05-16
JP2007130134 2007-05-16

Publications (1)

Publication Number Publication Date
WO2008140111A1 true WO2008140111A1 (ja) 2008-11-20

Family

ID=40002298

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/058902 Ceased WO2008140111A1 (ja) 2007-05-16 2008-05-15 シンナミド誘導体のワンポット製造方法

Country Status (9)

Country Link
US (1) US20080306272A1 (ja)
EP (1) EP2147917A4 (ja)
JP (1) JPWO2008140111A1 (ja)
KR (1) KR20100016580A (ja)
CN (1) CN101679360A (ja)
AU (1) AU2008250119A1 (ja)
CA (1) CA2687262A1 (ja)
IL (1) IL202098A0 (ja)
WO (1) WO2008140111A1 (ja)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005115990A1 (ja) 2004-05-26 2005-12-08 Eisai R & D Management Co., Ltd. シンナミド化合物
WO2006046575A1 (ja) 2004-10-26 2006-05-04 Eisai R & D Management Co., Ltd. シンナミド化合物の非晶質体
WO2007058305A1 (ja) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. シンナミド誘導体の製造方法

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1101156A (en) * 1965-09-22 1968-01-31 Hickson & Welch Ltd Triazole derivatives and their use as optical whitening agents
US3989816A (en) * 1975-06-19 1976-11-02 Nelson Research & Development Company Vehicle composition containing 1-substituted azacycloheptan-2-ones
ES2061432T3 (es) * 1985-10-09 1994-12-16 Shell Int Research Nuevas amidas de acido acrilico.
IT1205834B (it) * 1987-04-22 1989-03-31 Elbart Derivati tiodiossolanici ad attivita' mucolitica a procedimento per la loro preparazione
EP0468054B1 (en) * 1990-02-08 1997-05-28 Eisai Co., Ltd. Benzenesulfonamide derivative
AU680870B2 (en) * 1993-04-28 1997-08-14 Astellas Pharma Inc. New heterocyclic compounds
US5804577A (en) * 1995-09-12 1998-09-08 Hoffmann-La Roche Inc. Cephalosporin derivatives
KR20000010918A (ko) * 1996-05-10 2000-02-25 게리 엘. 윌콕스 카르볼린 유도체
CA2317008C (en) * 1997-12-31 2009-01-20 The University Of Kansas Water soluble prodrugs of tertiary amine containing drugs and methods of making thereof
US6235728B1 (en) * 1999-02-19 2001-05-22 Bristol-Myers Squibb Company Water-soluble prodrugs of azole compounds
AU2899400A (en) * 1999-03-04 2000-09-21 Nortran Pharmaceuticals Inc. Aminocycloalkyl cinnamide compounds for arrhythmia and as analgesics and anesthetics
AU2001241128A1 (en) * 2000-03-14 2001-09-24 Fujisawa Pharmaceutical Co. Ltd. Novel amide compounds
US20010051642A1 (en) * 2000-04-17 2001-12-13 Kyunghye Ahn Method for treating Alzheimer's disease
US6710058B2 (en) * 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
KR100515549B1 (ko) * 2000-12-04 2005-09-20 에프. 호프만-라 로슈 아게 글루타메이트 수용체 길항제로서의 페닐에테닐 또는페닐에티닐 유도체
GB0108770D0 (en) * 2001-04-06 2001-05-30 Eisai London Res Lab Ltd Inhibitors
MXPA04005427A (es) * 2001-12-10 2005-04-19 Amgen Inc Ligandos de receptor vainilloide y su uso en tratamientos.
HUP0500173A3 (en) * 2001-12-20 2009-03-30 Bristol Myers Squibb Co Alpha-sulphonamido-acetamide derivatives as beta-amyloid inhibitors and pharmaceutical compositions containing them
TW200307667A (en) * 2002-05-06 2003-12-16 Bristol Myers Squibb Co Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
PL375552A1 (en) * 2002-05-22 2005-11-28 Amgen Inc. Vanilloid receptor ligands and their medical applications
PT1511710E (pt) * 2002-05-31 2014-02-26 Proteotech Inc Compostos, composições e métodos para o tratamento de doenças da amiloide e sinucleínopatias tais como doença de alzheimer, diabetes do tipo 2, e doença de parkinson
WO2004007455A1 (de) * 2002-07-12 2004-01-22 Aventis Pharma Deutschland Gmbh Heterozyklisch substituierte benzoylharnstoffe, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US6900354B2 (en) * 2002-07-15 2005-05-31 Hoffman-La Roche Inc. 3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives
EP1594847A2 (en) * 2003-02-12 2005-11-16 Transtech Pharma, Inc. Substituted azole derivatives as therapeutic agents
MXPA05012281A (es) * 2003-05-14 2006-05-19 Torreypines Therapeutics Inc Compuestos y uso de los mismos en la modulacion beta amiloide.
JP5010917B2 (ja) * 2003-08-29 2012-08-29 エグゼリクシス， インコーポレイテッド ｃ−Ｋｉｔ調節因子および使用方法
AU2005214349B2 (en) * 2004-02-12 2011-11-03 Transtech Pharma, Inc. Substituted azole derivatives, compositions, and methods of use
US20090048448A1 (en) * 2005-11-18 2009-02-19 Ikuo Kushida Salts of cynnamide compound or solvates thereof
MY144960A (en) * 2005-11-24 2011-11-30 Eisai R&D Man Co Ltd Morpholine type cinnamide compound
US20070117839A1 (en) * 2005-11-24 2007-05-24 Eisai R&D Management Co., Ltd. Two cyclic cinnamide compound
TWI378091B (en) * 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
SA07280403B1 (ar) * 2006-07-28 2010-12-01 إيساي أر أند دي منجمنت كو. ليمتد ملح رباعي لمركب سيناميد
MX2009012163A (es) * 2007-05-11 2009-12-01 Hoffmann La Roche Hetarilanilinas como moduladores para beta-amiloide.
WO2009005729A1 (en) * 2007-06-29 2009-01-08 Schering Corporation Gamma secretase modulators

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005115990A1 (ja) 2004-05-26 2005-12-08 Eisai R & D Management Co., Ltd. シンナミド化合物
WO2006046575A1 (ja) 2004-10-26 2006-05-04 Eisai R & D Management Co., Ltd. シンナミド化合物の非晶質体
WO2007058305A1 (ja) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. シンナミド誘導体の製造方法

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
"Klein WL and 7 coauthors, Alzheimer's disease-affected brain: Presence of oligomeric A|] ligands (ADDLs) suggests a molecular basis for reversible memory loss", PROCEDING NATIONAL ACADEMY OF SCIENCE USA, vol. 100, no. 18, 2 September 2003 (2003-09-02), pages 10417 - 10422
"Nitsch RM and 16 coauthors, Antibodies against p-amyloid slow cognitive decline in Alzheimer's disease", NEURON, vol. 38, 22 May 2003 (2003-05-22), pages 547 - 554
"Shin Jikken Kagaku Koza", YUKI KAGOBUTSU NO GOSEI TO HANNOU, vol. 14, pages 1134 - 1188
See also references of EP2147917A4
T.W. GREENE: "Protective groups in Organic Synthesis", 1981, JOHN WILEY & SONS
T.W. GREENE; P.G. M. WUTS: "Protective groups In Organic Synthesis", JOHN WILEY & SONS, INC.

Also Published As

Publication number Publication date
JPWO2008140111A1 (ja) 2010-08-05
US20080306272A1 (en) 2008-12-11
EP2147917A4 (en) 2010-05-26
KR20100016580A (ko) 2010-02-12
CA2687262A1 (en) 2008-11-20
EP2147917A1 (en) 2010-01-27
IL202098A0 (en) 2010-06-16
CN101679360A (zh) 2010-03-24
AU2008250119A1 (en) 2008-11-20

Similar Documents

Publication Publication Date Title
WO2009044143A3 (en) Process for preparing benzofurans
WO2008108378A3 (en) Bicyclic oxomorpholine derivative
UA105671C2 (uk) Фармацевтична композиція, яка містить похідне хіноліну
WO2009016460A3 (en) Pyrazole compounds and their use as raf inhibitors
WO2006010546A3 (en) Aryl-pyridine derivatives as 11-beta-hsd1 inhibitors
WO2004101528A3 (en) Isoquinoline derivatives and their use as gfat inhibitors
WO2013053983A8 (en) Protein kinase inhibitors
NZ606001A (en) Derivatives of 1-amino-2-cyclobutylethylboronic acid
EA201001669A1 (ru) Замещенные пиримидин-5-карбоксамиды 281
WO2009069736A1 (ja) 含窒素化合物
WO2009154754A3 (en) Synthesis of deuterated morpholine derivatives
WO2010116140A8 (en) New process for preparing hydroxylamines and medicaments
WO2007147771A3 (en) Tetralin and indane derivatives and uses thereof
NZ595705A (en) Protease inhibitors
WO2014197345A3 (en) Imidazole derivatives and methods of use thereof for improving the pharmacokinetics of a drug
WO2009153461A3 (fr) Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro-2h-3- benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
IL185545A0 (en) Method of preparation of pure 4-pyrrolidinophenylbenzyl ether derivatives as maob inhibitors
NZ587490A (en) Anti-Microbial Compounds containing compounds with a sugar substituent
WO2009019815A1 (ja) 新規γセクレターゼ阻害剤
WO2009021943A3 (de) Neues herstellverfahren
WO2009075516A3 (en) Process for preparing pantoprazole sodium sesquihydrate
WO2008140111A1 (ja) シンナミド誘導体のワンポット製造方法
NZ589496A (en) Processes and compounds for the preparation of normorphinans
WO2009008287A1 (ja) ４－（トリクロロメチルチオ）アニリン類およびその製造方法、ならびに４－（トリフルオロメチルチオ）アニリン類の製造方法
WO2008120661A1 (ja) 新規な縮合ピロール誘導体

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200880016336.X

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08752763

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2009514176

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2687262

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2008250119

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 7367/DELNP/2009

Country of ref document: IN

Ref document number: 2008752763

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 20097023851

Country of ref document: KR

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2008250119

Country of ref document: AU

Date of ref document: 20080515

Kind code of ref document: A