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WO2008036891A3 - A method for quantitation of collagen in tissue - Google Patents

A method for quantitation of collagen in tissue Download PDF

Info

Publication number
WO2008036891A3
WO2008036891A3 PCT/US2007/079153 US2007079153W WO2008036891A3 WO 2008036891 A3 WO2008036891 A3 WO 2008036891A3 US 2007079153 W US2007079153 W US 2007079153W WO 2008036891 A3 WO2008036891 A3 WO 2008036891A3
Authority
WO
WIPO (PCT)
Prior art keywords
collagen
measurement
wound healing
newly
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/079153
Other languages
French (fr)
Other versions
WO2008036891A2 (en
Inventor
Patricia A Villanueva
Amy K Mcnulty
Herbert D Beniker
Kristine Kieswetter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KCI Licensing Inc
Original Assignee
KCI Licensing Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to MX2009003112A priority Critical patent/MX2009003112A/en
Priority to CA2664005A priority patent/CA2664005C/en
Priority to AU2007299680A priority patent/AU2007299680B2/en
Priority to JP2009529411A priority patent/JP5065397B2/en
Priority to BRPI0715287-6A2A priority patent/BRPI0715287A2/en
Priority to EP07814966A priority patent/EP2061898B1/en
Application filed by KCI Licensing Inc filed Critical KCI Licensing Inc
Publication of WO2008036891A2 publication Critical patent/WO2008036891A2/en
Publication of WO2008036891A3 publication Critical patent/WO2008036891A3/en
Priority to IL197650A priority patent/IL197650A0/en
Anticipated expiration legal-status Critical
Priority to NO20091433A priority patent/NO20091433L/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/22—Injection in high pressure liquid systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Fluid Mechanics (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

For successful wound healing to occur, the newly formed skin must generate tensile strength through collagen deposition. Measurement of collagen in the granulating wound bed may be predictive of successful wound healing. Existing methods for collagen measurement either require specialized equipment, or do not allow for discrimination of potential interfering molecules. Herein described is an accurate, specific and reliable method to extract and quantify collagen from tissue utilizing high pressure liquid chromatography techniques. The method is sensitive enough to measure the small amounts of collagen found in newly healing wounds.
PCT/US2007/079153 2006-09-21 2007-09-21 A method for quantitation of collagen in tissue Ceased WO2008036891A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA2664005A CA2664005C (en) 2006-09-21 2007-09-21 A method for quantitation of collagen in tissue
AU2007299680A AU2007299680B2 (en) 2006-09-21 2007-09-21 A method for quantitation of collagen in tissue
JP2009529411A JP5065397B2 (en) 2006-09-21 2007-09-21 Method for measuring collagen in tissues
BRPI0715287-6A2A BRPI0715287A2 (en) 2006-09-21 2007-09-21 "EVALUATION PROCEDURE EVALUATION METHOD"
EP07814966A EP2061898B1 (en) 2006-09-21 2007-09-21 A method for quantitation of collagen in tissue
MX2009003112A MX2009003112A (en) 2006-09-21 2007-09-21 A method for quantitation of collagen in tissue.
IL197650A IL197650A0 (en) 2006-09-21 2009-03-17 A method for quantitation of collagen in tissue
NO20091433A NO20091433L (en) 2006-09-21 2009-04-08 A method for quantifying collagen in tissues

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84625006P 2006-09-21 2006-09-21
US60/846,250 2006-09-21
US11/858,737 2007-09-20
US11/858,737 US7491541B2 (en) 2006-09-21 2007-09-20 Method for quantitation of collagen in tissue

Publications (2)

Publication Number Publication Date
WO2008036891A2 WO2008036891A2 (en) 2008-03-27
WO2008036891A3 true WO2008036891A3 (en) 2008-09-04

Family

ID=39201309

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/079153 Ceased WO2008036891A2 (en) 2006-09-21 2007-09-21 A method for quantitation of collagen in tissue

Country Status (12)

Country Link
US (2) US7491541B2 (en)
EP (1) EP2061898B1 (en)
JP (1) JP5065397B2 (en)
KR (1) KR20090068265A (en)
AU (1) AU2007299680B2 (en)
BR (1) BRPI0715287A2 (en)
CA (1) CA2664005C (en)
IL (1) IL197650A0 (en)
MX (1) MX2009003112A (en)
NO (1) NO20091433L (en)
RU (1) RU2452956C2 (en)
WO (1) WO2008036891A2 (en)

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US9421132B2 (en) 2011-02-04 2016-08-23 University Of Massachusetts Negative pressure wound closure device
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US10814049B2 (en) 2015-12-15 2020-10-27 University Of Massachusetts Negative pressure wound closure devices and methods
US10575991B2 (en) 2015-12-15 2020-03-03 University Of Massachusetts Negative pressure wound closure devices and methods
US10849988B2 (en) 2016-04-08 2020-12-01 The Regents Of The University Of California Hydrogel for engineered immune response to D-chirality peptides
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WO2020124038A1 (en) 2018-12-13 2020-06-18 University Of Massachusetts Negative pressure wound closure devices and methods
RU2717366C1 (en) * 2019-07-09 2020-03-23 Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Образования "Красноярский Государственный Медицинский Университет Имени Профессора В.Ф. Войно-Ясенецкого Министерства Здравоохранения Российской Федерации" Method for determining wound process stages by polarography in penetrating eye wounds in experiment
EP3842075B1 (en) 2019-12-23 2023-06-07 Paul Hartmann AG Siloxane-containing wound dressing
JP7390229B2 (en) * 2020-03-24 2023-12-01 学校法人東海大学 Method for analyzing biological samples and evaluating mitochondrial function
CN113820197A (en) * 2021-09-28 2021-12-21 山东海奥斯生物科技有限公司 Pretreatment method for detecting hydroxyproline content in collagen casing
KR102585392B1 (en) 2022-11-03 2023-10-06 한국기초과학지원연구원 Method and system for analyzing molecular weight distribution of collagen peptides

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