[go: up one dir, main page]

WO2008036375A3 - Utilisation du profilage cytologique base sur l'impedance pour classer des profils de reponses cellulaires lors d'une exposition a des agents biologiquement actifs - Google Patents

Utilisation du profilage cytologique base sur l'impedance pour classer des profils de reponses cellulaires lors d'une exposition a des agents biologiquement actifs Download PDF

Info

Publication number
WO2008036375A3
WO2008036375A3 PCT/US2007/020418 US2007020418W WO2008036375A3 WO 2008036375 A3 WO2008036375 A3 WO 2008036375A3 US 2007020418 W US2007020418 W US 2007020418W WO 2008036375 A3 WO2008036375 A3 WO 2008036375A3
Authority
WO
WIPO (PCT)
Prior art keywords
biologically active
active agents
cellular response
impedance
exposure
Prior art date
Application number
PCT/US2007/020418
Other languages
English (en)
Other versions
WO2008036375A2 (fr
Inventor
Xiaobo Wang
Yama A Abassi
Wenfu Zhang
Xiao Xu
Original Assignee
Acea Biosciences Corp
Xiaobo Wang
Yama A Abassi
Wenfu Zhang
Xiao Xu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acea Biosciences Corp, Xiaobo Wang, Yama A Abassi, Wenfu Zhang, Xiao Xu filed Critical Acea Biosciences Corp
Priority to EP07838594A priority Critical patent/EP2064644A4/fr
Publication of WO2008036375A2 publication Critical patent/WO2008036375A2/fr
Publication of WO2008036375A3 publication Critical patent/WO2008036375A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/30—Unsupervised data analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Software Systems (AREA)
  • Evolutionary Biology (AREA)
  • Public Health (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Computation (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Bioethics (AREA)
  • Artificial Intelligence (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

L'invention concerne des procédés de profilage multidimensionnel d'agents biologiquement actifs, permettant de déterminer les effets de ces agents sur des systèmes biologiques. Les procédés selon l'invention consistent à surveiller en temps réel l'impédance de réponses cellulaires à des agents biologiquement actifs et à classer par catégories les profils cinétiques cellulaires par groupes de profils de réponses cellulaires spécifiques de mécanismes. Le regroupement de profils de réponses cellulaires similaires permet d'établir la corrélation agent-mécanisme, ce qui permet d'identifier les applications thérapeutiques potentielles de ces agents ou d'avancer dans l'étude des réponses ou mécanismes cellulaires.
PCT/US2007/020418 2006-09-20 2007-09-20 Utilisation du profilage cytologique base sur l'impedance pour classer des profils de reponses cellulaires lors d'une exposition a des agents biologiquement actifs WO2008036375A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07838594A EP2064644A4 (fr) 2006-09-20 2007-09-20 Utilisation du profilage cytologique base sur l'impedance pour classer des profils de reponses cellulaires lors d'une exposition a des agents biologiquement actifs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84606706P 2006-09-20 2006-09-20
US60/846,067 2006-09-20

Publications (2)

Publication Number Publication Date
WO2008036375A2 WO2008036375A2 (fr) 2008-03-27
WO2008036375A3 true WO2008036375A3 (fr) 2008-10-16

Family

ID=39201101

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/020418 WO2008036375A2 (fr) 2006-09-20 2007-09-20 Utilisation du profilage cytologique base sur l'impedance pour classer des profils de reponses cellulaires lors d'une exposition a des agents biologiquement actifs

Country Status (2)

Country Link
EP (1) EP2064644A4 (fr)
WO (1) WO2008036375A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120015846A1 (en) * 2010-07-16 2012-01-19 Ye Fang Label-free Cellular Pharmacology For Drug Antitarget Assessment
GB201522323D0 (en) 2015-12-17 2016-02-03 Vrije Universiteit Brussel And Katholieke Universiteit Leuven Systems and methods for conducting electrochemical impedance spectroscopy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6051422A (en) * 1997-05-30 2000-04-18 Board Of Trustees, Leland Stanford, Jr., University Hybrid biosensors
WO2005077104A2 (fr) * 2004-02-09 2005-08-25 Xiao Xu Systemes de detection de cellules electroniques en temps reel et applications en matiere de profilage de cytotoxicite et dosages de composes
US20060050596A1 (en) * 2002-12-20 2006-03-09 Abassi Yama A Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6377057B1 (en) * 1999-02-18 2002-04-23 The Board Of Trustees Of The Leland Stanford Junior University Classification of biological agents according to the spectral density signature of evoked changes in cellular electric potential
ATE371865T1 (de) * 2003-07-14 2007-09-15 Mds Inc Dba Mds Sciex Markierungsfreies verfahren zur klassifizierung und charakterisierung zellulärer ereignisse

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6051422A (en) * 1997-05-30 2000-04-18 Board Of Trustees, Leland Stanford, Jr., University Hybrid biosensors
US20060050596A1 (en) * 2002-12-20 2006-03-09 Abassi Yama A Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
WO2005077104A2 (fr) * 2004-02-09 2005-08-25 Xiao Xu Systemes de detection de cellules electroniques en temps reel et applications en matiere de profilage de cytotoxicite et dosages de composes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
XING ET AL.: "Dynamic Monitoring of Cytotoxicity on Microelectronic Sensors", CHEMICAL RESEARCH IN TOXICOLOGY, vol. 18, 2005, pages 154 - 161, XP008104930 *

Also Published As

Publication number Publication date
EP2064644A2 (fr) 2009-06-03
WO2008036375A2 (fr) 2008-03-27
EP2064644A4 (fr) 2010-12-29

Similar Documents

Publication Publication Date Title
MX2010007936A (es) Anticuerpo anti-nr-10 y su uso.
EP1860443A4 (fr) Dispositif microcanaux, procede de production et procede d analyse du sang l utilisant
EP3809955A4 (fr) Détection, suivi et analyse d'événements urinaires
EP4373391A4 (fr) Systèmes et procédés d'évaluation de résultats de santé
WO2008008899A3 (fr) Procédés et systèmes pour attestation de conformité et mesures incitatives
FR2919608B1 (fr) Derives d'imidazolones,procede de preparation et applications biologiques
EP2712930A3 (fr) Marqueurs pharmacodynamiques par induction alpha d'interféron
EP1936378A4 (fr) Nanoparticule de biodetection, procede d'elaboration et applications
EP1877990A4 (fr) Systeme et procede de reperage et de surveillance des deplacements de personnes, de collecte et de transmission de donnees sur les deplacements de ces personnes et de communication avec des dernieres
BRPI0811262A2 (pt) Composto, composto ou sal do mesmo, composição farmacêutica, modulador de receptor de glicocorticóide, método para prevenção e/ou tratamento de bistúrbios metabólicos, doenças inflamatórias, doenças auto-imunes, doenças alérgicas, doenças do sistema nervoso central, doenças cardiovasculares, doenças relacionadas com homeostase ou glaucoma, e uso de pelo menos um composto ou um sal do mesmo
BRPI0920042A2 (pt) uso de um composto, dispositivo médico implantável, método para a sua fabricação, e, método in vitro para exterminar, inibir ou prevenir o crescimento de um biofilme microbiano.
CY1108540T1 (el) Ταυτοποιηση θεραπευτικων ενωσεων
BR0311700A (pt) Processo para a produção de uma preparação em forma de pelìcula e preparação em forma de pelìcula
BRPI0718469A2 (pt) Uso de um antagonista de interleucina 1 (il-1), método para tratar, inibir, ou melhorar pseudogota, uso de um ou mais agentes terapêuticos, e, produto.
RS52620B (en) THE USE OF CHITOSAN FOR THE TREATMENT OF INFLAMMATORY DISEASES OF NAILS
BRPI0814989A8 (pt) Derivado de triazolilpiridina cetona, e herbicidas
EP1878801A4 (fr) Procede de clivage de proteine et son utilisation
AU2003234549A1 (en) Systems and methods for identifying organ transplant risk
WO2007109733A3 (fr) Marqueurs de diagnostic et de pronostic et strategies de traitement de la sclerose en plaques
WO2008036375A3 (fr) Utilisation du profilage cytologique base sur l'impedance pour classer des profils de reponses cellulaires lors d'une exposition a des agents biologiquement actifs
FR2910137B1 (fr) Materiau electrolyte de dispositif electrocommandable, son procede de fabrication, dispositif electrocommandable le comprenant et procede de fabrication dudit dispositif
EP1996732A4 (fr) Détection, traitement de maladies mycobactériennes et découverte de médicaments
FR2929407B1 (fr) Dispositif d'analyse ou de comparaison biologique, procedes associes, procede de fabrication et utilisations
ATE326982T1 (de) Testsystem zur evaluierung der kompatibilität biologisch aktiver substanzen mit copolymeren
BRPI0512655A (pt) bioexame de rna

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07838594

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007838594

Country of ref document: EP