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WO2008036138A3 - Methods of identifying insect-specific spider toxin mimics - Google Patents

Methods of identifying insect-specific spider toxin mimics Download PDF

Info

Publication number
WO2008036138A3
WO2008036138A3 PCT/US2007/013342 US2007013342W WO2008036138A3 WO 2008036138 A3 WO2008036138 A3 WO 2008036138A3 US 2007013342 W US2007013342 W US 2007013342W WO 2008036138 A3 WO2008036138 A3 WO 2008036138A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
mimics
actx
identifying
spider toxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/013342
Other languages
French (fr)
Other versions
WO2008036138A2 (en
Inventor
Glenn F King
Brianna Sollod Mcfarland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Connecticut
Original Assignee
University of Connecticut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Connecticut filed Critical University of Connecticut
Priority to MX2008015580A priority Critical patent/MX2008015580A/en
Priority to AU2007297872A priority patent/AU2007297872A1/en
Priority to JP2009514359A priority patent/JP2009540295A/en
Priority to CA002654718A priority patent/CA2654718A1/en
Priority to EP07861321A priority patent/EP2035449A2/en
Publication of WO2008036138A2 publication Critical patent/WO2008036138A2/en
Publication of WO2008036138A3 publication Critical patent/WO2008036138A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5085—Supracellular entities, e.g. tissue, organisms of invertebrates
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/50—Molecular design, e.g. of drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Theoretical Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Medical Informatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Insects & Arthropods (AREA)
  • Evolutionary Biology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Computing Systems (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Disclosed herein are methods of identifying a candidate molecule that mimics at least a portion of the three-dimensional structure of a rU-ACTX-Hvla insecticidal toxin, the method comprising providing a molecular model made from the atomic co-ordinates for the rU-ACTX- HvIa insecticidal toxin as disclosed herein, using the molecular model to identify a candidate molecule that mimics the three-dimensional structure of the rU-ACTX-Hvla insecticidal toxin; and providing the candidate molecule that is identified. The method optionally comprises employing a molecular model identifying the pharmacophoric residues of U-ACTX as Q8, P9, N28, and V34.
PCT/US2007/013342 2006-06-06 2007-06-06 Methods of identifying insect-specific spider toxin mimics Ceased WO2008036138A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
MX2008015580A MX2008015580A (en) 2006-06-06 2007-06-06 Methods of identifying insect-specific spider toxin mimics.
AU2007297872A AU2007297872A1 (en) 2006-06-06 2007-06-06 Methods of identifying insect-specific spider toxin mimics
JP2009514359A JP2009540295A (en) 2006-06-06 2007-06-06 Methods for identifying insect-specific spider toxin mimetics
CA002654718A CA2654718A1 (en) 2006-06-06 2007-06-06 Methods of identifying insect-specific spider toxin mimics
EP07861321A EP2035449A2 (en) 2006-06-06 2007-06-06 Methods of identifying insect-specific spider toxin mimics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81115306P 2006-06-06 2006-06-06
US60/811,153 2006-06-06

Publications (2)

Publication Number Publication Date
WO2008036138A2 WO2008036138A2 (en) 2008-03-27
WO2008036138A3 true WO2008036138A3 (en) 2008-08-07

Family

ID=39201024

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/013342 Ceased WO2008036138A2 (en) 2006-06-06 2007-06-06 Methods of identifying insect-specific spider toxin mimics

Country Status (6)

Country Link
EP (1) EP2035449A2 (en)
JP (1) JP2009540295A (en)
AU (1) AU2007297872A1 (en)
CA (1) CA2654718A1 (en)
MX (1) MX2008015580A (en)
WO (1) WO2008036138A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11692016B2 (en) 2012-03-09 2023-07-04 Vestaron Corporation High gene expression yeast strain
IL272522B2 (en) * 2012-03-09 2024-11-01 Vestaron Corp Production of toxic peptides, expression of peptides in plants, and combinations of high-cysteine insecticidal peptides
EP3528617A4 (en) 2016-10-21 2020-11-25 Vestaron Corporation Fissile peptides and insecticides and nematicidal proteins with them

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998057988A1 (en) * 1997-06-13 1998-12-23 The University Of Sydney Insecticidal compounds and methods for selection thereof
WO2006052806A2 (en) * 2004-11-04 2006-05-18 University Of Connecticut Insectidical polypeptides and methods of use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998057988A1 (en) * 1997-06-13 1998-12-23 The University Of Sydney Insecticidal compounds and methods for selection thereof
WO2006052806A2 (en) * 2004-11-04 2006-05-18 University Of Connecticut Insectidical polypeptides and methods of use thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ESCOUBAS ET AL: "Venom landscapes: Mining the complexity of spider venoms via a combined cDNA and mass spectrometric approach", TOXICON, ELMSFORD, NY, US, vol. 47, no. 6, 1 May 2006 (2006-05-01), pages 650 - 663, XP005419714, ISSN: 0041-0101 *
TEDFORD HUGO W ET AL: "Australian funnel-web spiders: master insecticide chemists", TOXICON, ELMSFORD, NY, US, vol. 43, no. 5, 1 April 2004 (2004-04-01), pages 601 - 618, XP002431433, ISSN: 0041-0101 *

Also Published As

Publication number Publication date
AU2007297872A1 (en) 2008-03-27
WO2008036138A2 (en) 2008-03-27
EP2035449A2 (en) 2009-03-18
MX2008015580A (en) 2009-01-13
CA2654718A1 (en) 2008-03-27
JP2009540295A (en) 2009-11-19

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