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WO2008034895A3 - Ansamycin derivatives - Google Patents

Ansamycin derivatives Download PDF

Info

Publication number
WO2008034895A3
WO2008034895A3 PCT/EP2007/060032 EP2007060032W WO2008034895A3 WO 2008034895 A3 WO2008034895 A3 WO 2008034895A3 EP 2007060032 W EP2007060032 W EP 2007060032W WO 2008034895 A3 WO2008034895 A3 WO 2008034895A3
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives
ansamycin derivatives
ansamycin
diseases
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2007/060032
Other languages
French (fr)
Other versions
WO2008034895A2 (en
Inventor
Friedrich Georg Hansske
Simon Werner
Peter Eckard
Rajendra-Prasad Maskey
Hans-Falk Rasser
Bernd Sontag
Iris Grun-Wollny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Discovery Partners International GmbH
Original Assignee
Discovery Partners International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Discovery Partners International GmbH filed Critical Discovery Partners International GmbH
Publication of WO2008034895A2 publication Critical patent/WO2008034895A2/en
Publication of WO2008034895A3 publication Critical patent/WO2008034895A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to novel ansamycin derivatives of Formula (I) or (II): medicinal products that contain these or salts thereof, and the use of the geldanamycin derivatives for the treatment of diseases, in particular neoplastic diseases.
PCT/EP2007/060032 2006-09-21 2007-09-21 Ansamycin derivatives Ceased WO2008034895A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE200610044472 DE102006044472A1 (en) 2006-09-21 2006-09-21 Geldanamycin derivatives
DE102006044472.8 2006-09-21

Publications (2)

Publication Number Publication Date
WO2008034895A2 WO2008034895A2 (en) 2008-03-27
WO2008034895A3 true WO2008034895A3 (en) 2008-05-08

Family

ID=39092807

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/060032 Ceased WO2008034895A2 (en) 2006-09-21 2007-09-21 Ansamycin derivatives

Country Status (2)

Country Link
DE (1) DE102006044472A1 (en)
WO (1) WO2008034895A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109295125B (en) * 2018-10-08 2020-12-18 中国科学院南海海洋研究所 Ansamycin compound and its preparation method and application

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005056531A1 (en) * 2003-11-12 2005-06-23 Kosan Biosciences, Inc. 11-o-methylgeldanamycin compounds
WO2007059116A2 (en) * 2005-11-14 2007-05-24 Abraxis Bioscience, Inc. Geldanamycin derivatives and pharmaceutical compositions thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005056531A1 (en) * 2003-11-12 2005-06-23 Kosan Biosciences, Inc. 11-o-methylgeldanamycin compounds
WO2007059116A2 (en) * 2005-11-14 2007-05-24 Abraxis Bioscience, Inc. Geldanamycin derivatives and pharmaceutical compositions thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
COWEN, L.E., LINDQUIST, S., SCIENCE, vol. 309, 2005, pages 2185, XP002470935 *
KUMAR R ET AL: "Plasmodium falciparum calcineurin and its association with heat shock protein 90: mechanisms for the antimalarial activity of cyclosporin A and synergism with geldanamycin", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 141, no. 1, May 2005 (2005-05-01), pages 29 - 37, XP004823798, ISSN: 0166-6851 *

Also Published As

Publication number Publication date
WO2008034895A2 (en) 2008-03-27
DE102006044472A1 (en) 2008-04-03

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