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WO2008033894A3 - Compounds with activity at estrogen receptors - Google Patents

Compounds with activity at estrogen receptors Download PDF

Info

Publication number
WO2008033894A3
WO2008033894A3 PCT/US2007/078236 US2007078236W WO2008033894A3 WO 2008033894 A3 WO2008033894 A3 WO 2008033894A3 US 2007078236 W US2007078236 W US 2007078236W WO 2008033894 A3 WO2008033894 A3 WO 2008033894A3
Authority
WO
WIPO (PCT)
Prior art keywords
estrogen receptors
compounds
activity
reducing
levels
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/078236
Other languages
French (fr)
Other versions
WO2008033894A2 (en
Inventor
Fabrice Piu
Daniel W Gil
Roger Olsson
Magnus Gustafsson
Lene Hyldtoft
Karyn F Siemasko
Michael E Stern
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acadia Pharmaceuticals Inc
Original Assignee
Acadia Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acadia Pharmaceuticals Inc filed Critical Acadia Pharmaceuticals Inc
Publication of WO2008033894A2 publication Critical patent/WO2008033894A2/en
Publication of WO2008033894A3 publication Critical patent/WO2008033894A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Disclosed herein are methods of treating neuropathic pain, reducing inflammation, reducing IL-4 levels, and reducing IFN-γ levels, using various di-aromatic compounds for use as estrogen receptors β agonists.
PCT/US2007/078236 2006-09-14 2007-09-12 Compounds with activity at estrogen receptors Ceased WO2008033894A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US82568206P 2006-09-14 2006-09-14
US60/825,682 2006-09-14
US94818807P 2007-07-05 2007-07-05
US60/948,188 2007-07-05

Publications (2)

Publication Number Publication Date
WO2008033894A2 WO2008033894A2 (en) 2008-03-20
WO2008033894A3 true WO2008033894A3 (en) 2008-11-20

Family

ID=39184538

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/078236 Ceased WO2008033894A2 (en) 2006-09-14 2007-09-12 Compounds with activity at estrogen receptors

Country Status (1)

Country Link
WO (1) WO2008033894A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2200994T3 (en) 2007-10-26 2014-04-22 Acadia Pharm Inc CONDENSED RELATIONS WITH ESTROGEN RECEPTOR ACTIVITY
EP2554532A1 (en) * 2011-08-01 2013-02-06 Acadia Pharmaceuticals Inc. Diphenyl substituted cyclohexane derivatives, useful as modulators of the estrogen receptors beta
JO3407B1 (en) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd Tetrahydropyrazolopyrimidines
CN105960236A (en) 2013-12-05 2016-09-21 卡罗医药股份公司 Estrogen receptor beta agonists for use in treating mesothelioma
US20220380378A1 (en) * 2021-04-22 2022-12-01 Essa Pharma, Inc. Androgen receptor modulators and methods for their use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050256210A1 (en) * 2004-05-04 2005-11-17 Roger Olsson Compounds with activity at estrogen receptors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050256210A1 (en) * 2004-05-04 2005-11-17 Roger Olsson Compounds with activity at estrogen receptors

Also Published As

Publication number Publication date
WO2008033894A2 (en) 2008-03-20

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