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WO2008031910A3 - Modelos experimentales para la metástasis a hueso de cáncer de pulmón no microcítico - Google Patents

Modelos experimentales para la metástasis a hueso de cáncer de pulmón no microcítico Download PDF

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Publication number
WO2008031910A3
WO2008031910A3 PCT/ES2007/000519 ES2007000519W WO2008031910A3 WO 2008031910 A3 WO2008031910 A3 WO 2008031910A3 ES 2007000519 W ES2007000519 W ES 2007000519W WO 2008031910 A3 WO2008031910 A3 WO 2008031910A3
Authority
WO
WIPO (PCT)
Prior art keywords
bone
lung cancer
cell
cancer metastasis
cell line
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/ES2007/000519
Other languages
English (en)
French (fr)
Other versions
WO2008031910A2 (es
Inventor
Cordero Fernando Lecanda
Cambra Silvestre Vicent
Las Rivas Sanz Francisco Ja De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Proyecto de Biomedicina CIMA SL
Original Assignee
Proyecto de Biomedicina CIMA SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proyecto de Biomedicina CIMA SL filed Critical Proyecto de Biomedicina CIMA SL
Publication of WO2008031910A2 publication Critical patent/WO2008031910A2/es
Publication of WO2008031910A3 publication Critical patent/WO2008031910A3/es
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La presente invención se refiere a varias líneas celulares de cáncer de pulmón no microcítico con capacidad de metastatizar a hueso con elevada eficiencia. Estas líneas celulares son: una línea celular de carcinoma de células grandes NCI-H640 que sobreexpresa los genes TCF4 y PKD3 junto con MCAM o SUSD5, pudiendo sobrexpresar adicionalmente KIAA0960; una línea celular de carcinoide H727 que sobreexpresa los genes GAL, SPOCK2, CRIP2, ELF5 y EPCR; y una línea celular de carcinoma broncoalveolar A549 que sobreexpresa los genes IL11, PITX1, HDAC4, RHOB, ROBO1 y SLC26A2. Asimismo, la presente invención se refiere al procedimiento de obtención de dichas líneas celulares, a los modelos correspondientes y al uso de los anteriores.
PCT/ES2007/000519 2006-09-15 2007-09-14 Modelos experimentales para la metástasis a hueso de cáncer de pulmón no microcítico Ceased WO2008031910A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200602349 2006-09-15
ESP200602349 2006-09-15

Publications (2)

Publication Number Publication Date
WO2008031910A2 WO2008031910A2 (es) 2008-03-20
WO2008031910A3 true WO2008031910A3 (es) 2008-05-08

Family

ID=39184165

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2007/000519 Ceased WO2008031910A2 (es) 2006-09-15 2007-09-14 Modelos experimentales para la metástasis a hueso de cáncer de pulmón no microcítico

Country Status (1)

Country Link
WO (1) WO2008031910A2 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2339524B1 (es) * 2008-08-28 2011-03-22 Proyecto De Biomedicina Cima, S.L. Nuevo biomarcador como diana terapeutica en cancer de pulmon.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050181375A1 (en) * 2003-01-10 2005-08-18 Natasha Aziz Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of metastatic cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050181375A1 (en) * 2003-01-10 2005-08-18 Natasha Aziz Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of metastatic cancer

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
HOANG C.D. ET AL.: "Analysis of paired primary lung and lymph node tumor cells: a model of metastatic potential by multiple genetic programs", CANCER DETECTION AND PREVENTION, vol. 29, 2005, pages 509 - 519 *
IGUCHI H. ET AL.: "An experimental model of bone metastasis by human lung cancer cells: the role of parathyroid hormone-related protein in bone metastasis", CANCER RESEARCH, vol. 56, no. 17, September 1996 (1996-09-01), pages 4040 - 4043 *
KANG Y. ET AL.: "A multigenic program mediating breast cancer metastasis to bone", CANCER CELL, vol. 3, no. 6, June 2003 (2003-06-01), pages 537 - 549, XP008062522, DOI: doi:10.1016/S1535-6108(03)00132-6 *
LI C.-Y. ET AL.: "Expression of T cell factor-4 in non-small-cell lung cancer", CHINESE MEDICAL JOURNAL, vol. 118, no. 2, 2005, Retrieved from the Internet <URL:http://www.cmj.org/Perodical/paperlist.asp?id=LW9742&linkintype=pubmed> *
PUTZ E. ET AL.: "Phenotypic characteristics of cell lines derived from disseminated cancer cells in bone marrow of patients with solid epithelial tumors: establishment of working models for human micrometastases", CANCER RESEARCH, vol. 59, no. 1, January 1999 (1999-01-01), pages 241 - 248 *
RYKX A. ET AL.: "Protein Kinase D: a family affair", FEBS LETTERS, vol. 546, no. 1, July 2003 (2003-07-01), pages 81 - 86, XP004433623, DOI: doi:10.1016/S0014-5793(03)00487-3 *
YANG M. ET AL.: "Widespread skeleta metastatic potential of human lung cancer revealed by green fluorescent protein expression", CANCER RESEARCH, vol. 58, no. 19, October 1998 (1998-10-01), pages 4217 - 4221 *

Also Published As

Publication number Publication date
WO2008031910A2 (es) 2008-03-20

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