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WO2008030281A3 - Optical resonances in droplets in a microchannel - Google Patents

Optical resonances in droplets in a microchannel Download PDF

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Publication number
WO2008030281A3
WO2008030281A3 PCT/US2007/012590 US2007012590W WO2008030281A3 WO 2008030281 A3 WO2008030281 A3 WO 2008030281A3 US 2007012590 W US2007012590 W US 2007012590W WO 2008030281 A3 WO2008030281 A3 WO 2008030281A3
Authority
WO
WIPO (PCT)
Prior art keywords
resonances
droplets
microchannel
morphology dependent
optical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/012590
Other languages
French (fr)
Other versions
WO2008030281A2 (en
Inventor
Melikhan Tanyeri
Richard Perron
Ian Kennedy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California Berkeley
University of California San Diego UCSD
Original Assignee
University of California Berkeley
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California Berkeley, University of California San Diego UCSD filed Critical University of California Berkeley
Publication of WO2008030281A2 publication Critical patent/WO2008030281A2/en
Anticipated expiration legal-status Critical
Publication of WO2008030281A3 publication Critical patent/WO2008030281A3/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks

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  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)

Abstract

Methods and a microchannel apparatus form microdroplets that enable internal reflection within the droplets sufficient to support morphology dependent resonances. The morphology dependent resonances can be used for detecting an analyte of interest within the droplets according to various known methods. The droplets comprise glycerol and a fluorescent dye, and when excited by a pulsed laser, strong resonances and lasing are established inside the droplet. The microdroplet acts as a high quality factor optical cavity that supports morphology dependent resonances (MDRs). Enhanced radiative energy transfer is mediated through these optical resonances.
PCT/US2007/012590 2006-05-25 2007-05-23 Optical resonances in droplets in a microchannel Ceased WO2008030281A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80876806P 2006-05-25 2006-05-25
US60/808,768 2006-05-25

Publications (2)

Publication Number Publication Date
WO2008030281A2 WO2008030281A2 (en) 2008-03-13
WO2008030281A3 true WO2008030281A3 (en) 2009-04-09

Family

ID=39157727

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/012590 Ceased WO2008030281A2 (en) 2006-05-25 2007-05-23 Optical resonances in droplets in a microchannel

Country Status (1)

Country Link
WO (1) WO2008030281A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3693086B1 (en) * 2019-02-08 2020-12-09 Lightcast Discovery Ltd Microdroplet manipulation method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5131916A (en) * 1990-03-01 1992-07-21 Bayer Aktiengesellschaft Colored fluorescent polymer emulsions for marker pens: graft copolymers and fluorescent dyes in aqueous phase
US20060153924A1 (en) * 2003-03-31 2006-07-13 Medical Research Council Selection by compartmentalised screening

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5131916A (en) * 1990-03-01 1992-07-21 Bayer Aktiengesellschaft Colored fluorescent polymer emulsions for marker pens: graft copolymers and fluorescent dyes in aqueous phase
US20060153924A1 (en) * 2003-03-31 2006-07-13 Medical Research Council Selection by compartmentalised screening

Also Published As

Publication number Publication date
WO2008030281A2 (en) 2008-03-13

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