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WO2008023248A3 - Novel macrolides and ketolides having antimicrobial activity - Google Patents

Novel macrolides and ketolides having antimicrobial activity Download PDF

Info

Publication number
WO2008023248A3
WO2008023248A3 PCT/IB2007/002405 IB2007002405W WO2008023248A3 WO 2008023248 A3 WO2008023248 A3 WO 2008023248A3 IB 2007002405 W IB2007002405 W IB 2007002405W WO 2008023248 A3 WO2008023248 A3 WO 2008023248A3
Authority
WO
WIPO (PCT)
Prior art keywords
antimicrobial activity
ketolides
compounds
macrolides
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2007/002405
Other languages
French (fr)
Other versions
WO2008023248A2 (en
Inventor
Milind Dattatraya Sindkhedkar
Vijaya Narayan Desai
Rajesh Maganlal Loriya
Mahesh Vithalbhai Patel
Bharat Kalidas Trivedi
Rajesh Onkardas Bora
Santosh Devidas Diwakar
Ganesh Rajaram Jadhav
Shivaji Sampatrao Pawar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wockhardt Research Centre
Original Assignee
Wockhardt Research Centre
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt Research Centre filed Critical Wockhardt Research Centre
Priority to EP07804796A priority Critical patent/EP2056844A4/en
Priority to CA002661538A priority patent/CA2661538A1/en
Priority to JP2009525123A priority patent/JP2010501541A/en
Publication of WO2008023248A2 publication Critical patent/WO2008023248A2/en
Priority to US12/379,539 priority patent/US8097594B2/en
Anticipated expiration legal-status Critical
Publication of WO2008023248A3 publication Critical patent/WO2008023248A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The present invention provides compounds having antimicrobial activity for preventing and treating diseases caused by microbial infections. Thus, the present invention relates to novel • semi-synthetic 11,12-γ lactone macrolides and ketolides having antimicrobial activity, processes for making compounds as well as pharmaceutical compositions containing said compounds as active ingredients and methods of treating microbial infections with the compounds.
PCT/IB2007/002405 2006-08-24 2007-08-22 Novel macrolides and ketolides having antimicrobial activity Ceased WO2008023248A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP07804796A EP2056844A4 (en) 2006-08-24 2007-08-22 Novel macrolides and ketolides having antimicrobial activity
CA002661538A CA2661538A1 (en) 2006-08-24 2007-08-22 Novel macrolides and ketolides having antimicrobial activity
JP2009525123A JP2010501541A (en) 2006-08-24 2007-08-22 Novel macrolides and ketolides with antibacterial activity
US12/379,539 US8097594B2 (en) 2006-08-24 2009-02-24 Macrolides and ketolides having antimicrobial activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1336/MUM/2006 2006-08-24
IN1336MU2006 2006-08-24

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/379,539 Continuation-In-Part US8097594B2 (en) 2006-08-24 2009-02-24 Macrolides and ketolides having antimicrobial activity

Publications (2)

Publication Number Publication Date
WO2008023248A2 WO2008023248A2 (en) 2008-02-28
WO2008023248A3 true WO2008023248A3 (en) 2009-04-23

Family

ID=39107171

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/002405 Ceased WO2008023248A2 (en) 2006-08-24 2007-08-22 Novel macrolides and ketolides having antimicrobial activity

Country Status (7)

Country Link
US (1) US8097594B2 (en)
EP (1) EP2056844A4 (en)
JP (1) JP2010501541A (en)
KR (1) KR20090042971A (en)
CN (1) CN101541331A (en)
CA (1) CA2661538A1 (en)
WO (1) WO2008023248A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9878999B2 (en) 2011-03-24 2018-01-30 H. Lee Moffitt Cancer Center And Research Institute, Inc. Proteasome chymotrypsin-like inhibition using PI-1833 analogs

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5718053B2 (en) 2007-08-27 2015-05-13 ヘリコン・セラピューティクス・インコーポレーテッド Therapeutic isoxazole compounds
RU2474581C2 (en) * 2007-12-26 2013-02-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Method of producing heterocycle-substituted pyridine derivatives
AU2010252641B2 (en) * 2009-05-27 2015-09-17 Wockhardt Research Centre Ketolide compounds having antimicrobial activity
MX348084B (en) * 2010-12-09 2017-05-26 Wockhardt Ltd Ketolide compounds.
WO2012117357A2 (en) * 2011-03-01 2012-09-07 Wockhardt Limited Process for preparation of ketolide intermediates
CN103619863B (en) * 2011-03-22 2016-03-16 沃克哈特有限公司 The preparation method of ketolide compound
CN102260225B (en) * 2011-06-02 2013-08-21 蒋杰 Phenylpiperazine derivatives for inhibiting tumor metastasis and tumor angiogenesis
HK1242920A1 (en) * 2014-10-08 2018-07-06 哈佛大学的校长及成员们 14-membered ketolides and methods of their preparation and use
US20210122777A1 (en) * 2017-03-16 2021-04-29 Wockhardt Limited A process for preparing ketolide compounds
ES2948122A1 (en) * 2022-02-10 2023-08-31 Fundacion Instituto De Investig Sanitaria Aragon Compounds for the treatment and/or prevention of an infection or disease caused by Helicobacter or Campylobacter (Machine-translation by Google Translate, not legally binding)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6740642B2 (en) * 2000-08-22 2004-05-25 Basilea Parmaceutica Ag Macrolides with antibacterial activity

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2473525A1 (en) 1980-01-11 1981-07-17 Roussel Uclaf NOVEL OXIMES DERIVED FROM ERYTHROMYCIN, PROCESS FOR PREPARING THEM AND THEIR APPLICATION AS MEDICAMENTS
US4331803A (en) 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
YU43006B (en) 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
FR2719587B1 (en) 1994-05-03 1996-07-12 Roussel Uclaf New erythromycin derivatives, their preparation process and their use as drugs.
EP1291351B1 (en) 1996-09-04 2005-07-13 Abbott Laboratories 6-0 substituted ketolides having antibacterial activity
CZ20031751A3 (en) 2000-12-21 2004-03-17 Glaxo Group Limited Macrolides
GB0031312D0 (en) * 2000-12-21 2001-02-07 Glaxo Group Ltd Macrolides
DE60203623T2 (en) 2001-07-19 2006-01-19 CV Therapeutics, Inc., Palo Alto SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS FATTY-OXIDATION INHIBITORS
GB0127349D0 (en) 2001-11-14 2002-01-02 Glaxo Group Ltd Macrolides
US6995143B2 (en) 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US6727229B2 (en) 2002-08-19 2004-04-27 Enanta Pharmaceuticals, Inc. 11,12-substituted lactone ketolide derivatives having antibacterial activity
JP5112079B2 (en) * 2005-02-09 2013-01-09 バジリア ファルマスーチカ アーゲー New macro ride

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6740642B2 (en) * 2000-08-22 2004-05-25 Basilea Parmaceutica Ag Macrolides with antibacterial activity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9878999B2 (en) 2011-03-24 2018-01-30 H. Lee Moffitt Cancer Center And Research Institute, Inc. Proteasome chymotrypsin-like inhibition using PI-1833 analogs

Also Published As

Publication number Publication date
CA2661538A1 (en) 2008-02-28
CN101541331A (en) 2009-09-23
EP2056844A4 (en) 2010-11-24
JP2010501541A (en) 2010-01-21
WO2008023248A2 (en) 2008-02-28
US20090247478A1 (en) 2009-10-01
KR20090042971A (en) 2009-05-04
EP2056844A2 (en) 2009-05-13
US8097594B2 (en) 2012-01-17

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