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WO2008023027A3 - Méthode de fabrication de comprimés de pramipexole dihydrochlorure - Google Patents

Méthode de fabrication de comprimés de pramipexole dihydrochlorure Download PDF

Info

Publication number
WO2008023027A3
WO2008023027A3 PCT/EP2007/058696 EP2007058696W WO2008023027A3 WO 2008023027 A3 WO2008023027 A3 WO 2008023027A3 EP 2007058696 W EP2007058696 W EP 2007058696W WO 2008023027 A3 WO2008023027 A3 WO 2008023027A3
Authority
WO
WIPO (PCT)
Prior art keywords
storage stability
pramipexole dihydrochloride
high storage
tablets
dihydrochloride tablets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2007/058696
Other languages
English (en)
Other versions
WO2008023027A2 (fr
Inventor
Hans-Werner Wernersbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38963081&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2008023027(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US11/734,041 external-priority patent/US20080254118A1/en
Priority to EP07788511A priority Critical patent/EP2056795A2/fr
Priority to AU2007287560A priority patent/AU2007287560A1/en
Priority to BRPI0715835-1A priority patent/BRPI0715835A2/pt
Priority to MX2009001884A priority patent/MX2009001884A/es
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority to CA002661616A priority patent/CA2661616A1/fr
Priority to JP2009525064A priority patent/JP2010501525A/ja
Publication of WO2008023027A2 publication Critical patent/WO2008023027A2/fr
Publication of WO2008023027A3 publication Critical patent/WO2008023027A3/fr
Priority to IL197130A priority patent/IL197130A0/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne une méthode de fabrication de comprimés de pramipexole dihydrochlorure, et en particulier une méthode fabrication permettant d'obtenir des comprimés dotés de propriétés leur conférant une grande stabilité au stockage.
PCT/EP2007/058696 2006-08-24 2007-08-22 Méthode de fabrication de comprimés de pramipexole dihydrochlorure Ceased WO2008023027A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2009525064A JP2010501525A (ja) 2006-08-24 2007-08-22 プラミペキソールジヒドロクロライド錠剤の調製方法
CA002661616A CA2661616A1 (fr) 2006-08-24 2007-08-22 Methode de fabrication de comprimes de pramipexole dihydrochlorure
AU2007287560A AU2007287560A1 (en) 2006-08-24 2007-08-22 Process for preparing pramipexole dihydrochloride tablets with high storage stability
BRPI0715835-1A BRPI0715835A2 (pt) 2006-08-24 2007-08-22 processo para preparar comprimidos de dicloridrato de pramipexol
MX2009001884A MX2009001884A (es) 2006-08-24 2007-08-22 Proceso para preparar comprimidos de dihidrocloruro de pramipexol con elevada estabilidad de conservacion.
EP07788511A EP2056795A2 (fr) 2006-08-24 2007-08-22 Méthode de fabrication de comprimés de pramipexole dihydrochloride à haute stabilité
IL197130A IL197130A0 (en) 2006-08-24 2009-02-19 Process for preparing pramipexole dihydrochloride tablets

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US46705006A 2006-08-24 2006-08-24
US11/467,050 2006-08-24
US11/734,041 US20080254118A1 (en) 2007-04-11 2007-04-11 Process for preparing pramipexole dihydrochloride tablets
US11/734,041 2007-04-11

Publications (2)

Publication Number Publication Date
WO2008023027A2 WO2008023027A2 (fr) 2008-02-28
WO2008023027A3 true WO2008023027A3 (fr) 2008-04-17

Family

ID=38963081

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/058696 Ceased WO2008023027A2 (fr) 2006-08-24 2007-08-22 Méthode de fabrication de comprimés de pramipexole dihydrochlorure

Country Status (13)

Country Link
EP (1) EP2056795A2 (fr)
JP (1) JP2010501525A (fr)
KR (1) KR20090045943A (fr)
AR (1) AR062509A1 (fr)
AU (1) AU2007287560A1 (fr)
BR (1) BRPI0715835A2 (fr)
CA (1) CA2661616A1 (fr)
CL (1) CL2007002477A1 (fr)
IL (1) IL197130A0 (fr)
MX (1) MX2009001884A (fr)
RU (1) RU2009110253A (fr)
TW (1) TW200816998A (fr)
WO (1) WO2008023027A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8518926B2 (en) 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
CN101448498B (zh) 2006-05-16 2011-04-27 诺普神经科学股份有限公司 R(+)和s(-)普拉克索的组合物以及使用该组合物的方法
US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
CA2681110A1 (fr) 2007-03-14 2008-09-18 Knopp Neurosciences, Inc. Synthese de benzothiazole diamines substituees et purifiees du point de vue chiral
US20080254117A1 (en) * 2007-04-10 2008-10-16 Noel Cotton Process for preparing pramipexole dihydrochloride tablets
WO2010022140A1 (fr) 2008-08-19 2010-02-25 Knopp Neurosciences, Inc. Compositions et procédés employant du (r)-pramipexole
TR200906997A1 (tr) 2009-09-11 2011-03-21 Sanovel �La� San. Ve T�C. A. �. Pramipeksol farmasötik bileşimleri.
EP2462925A1 (fr) 2010-11-12 2012-06-13 Neuraxpharm Arzneimittel GmbH Granulé de dihydrochlorure de pramipexole
KR101712049B1 (ko) * 2010-11-17 2017-03-03 엘지이노텍 주식회사 발광 소자
US9512096B2 (en) 2011-12-22 2016-12-06 Knopp Biosciences, LLP Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
EP3838271B1 (fr) 2013-07-12 2025-09-03 Areteia Therapeutics, Inc. Traitement de taux élevés d'éosinophiles et/ou de basophiles
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
EP3033081B1 (fr) 2013-08-13 2021-05-12 Knopp Biosciences LLC Compositions et méthodes pour le traitement de l'urticaire chronique
WO2015023786A1 (fr) 2013-08-13 2015-02-19 Knopp Biosciences Llc Compositions et méthodes de traitement de troubles des cellules plasmatiques et de troubles prolymphocytaires à cellules b

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000044353A1 (fr) * 1999-01-29 2000-08-03 Losan Pharma Gmbh Compositions pharmaceutiques
WO2003053402A1 (fr) * 2001-12-20 2003-07-03 Pharmacia Corporation Formes dosifiees a liberation soutenue d'ordre zero et procede de production associe
WO2004100857A2 (fr) * 2003-05-07 2004-11-25 Akina, Inc. Granules a teneur elevee en plastique, destines a la fabrication de comprimes a dissolution rapide
WO2006015943A2 (fr) * 2004-08-13 2006-02-16 Boehringer Ingelheim International Gmbh Préparation d’une pastille à autorisation de sortie élargie, contenant du pramipexole ou un sel de pramipexole pharmaceutiquement acceptable, procédé de fabrication et d’utilisation de cette pastille
WO2006015942A1 (fr) * 2004-08-13 2006-02-16 Boehringer Ingelheim International Gmbh Préparation de comprimé à autorisation de sortie élargie, contenant du pramipexole ou un sel de pramipexole pharmaceutiquement acceptable, procédé de fabrication et d’utilisation de ce comprimé
WO2007070843A2 (fr) * 2005-12-15 2007-06-21 Acusphere, Inc. Procédés de préparation de formulations pharmaceutiques à base de particules destinées à une administration orale

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0998933A1 (fr) * 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Procédé pour la préparation de compositions pharmaucetiques contenant des diphosphonates pour administration orale
JP4446177B2 (ja) * 2005-01-21 2010-04-07 東和薬品株式会社 耐湿性口腔内崩壊錠の製造方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000044353A1 (fr) * 1999-01-29 2000-08-03 Losan Pharma Gmbh Compositions pharmaceutiques
WO2003053402A1 (fr) * 2001-12-20 2003-07-03 Pharmacia Corporation Formes dosifiees a liberation soutenue d'ordre zero et procede de production associe
WO2004100857A2 (fr) * 2003-05-07 2004-11-25 Akina, Inc. Granules a teneur elevee en plastique, destines a la fabrication de comprimes a dissolution rapide
WO2006015943A2 (fr) * 2004-08-13 2006-02-16 Boehringer Ingelheim International Gmbh Préparation d’une pastille à autorisation de sortie élargie, contenant du pramipexole ou un sel de pramipexole pharmaceutiquement acceptable, procédé de fabrication et d’utilisation de cette pastille
WO2006015942A1 (fr) * 2004-08-13 2006-02-16 Boehringer Ingelheim International Gmbh Préparation de comprimé à autorisation de sortie élargie, contenant du pramipexole ou un sel de pramipexole pharmaceutiquement acceptable, procédé de fabrication et d’utilisation de ce comprimé
WO2007070843A2 (fr) * 2005-12-15 2007-06-21 Acusphere, Inc. Procédés de préparation de formulations pharmaceutiques à base de particules destinées à une administration orale

Also Published As

Publication number Publication date
EP2056795A2 (fr) 2009-05-13
JP2010501525A (ja) 2010-01-21
MX2009001884A (es) 2009-03-06
CA2661616A1 (fr) 2008-02-28
RU2009110253A (ru) 2010-09-27
KR20090045943A (ko) 2009-05-08
CL2007002477A1 (es) 2008-04-18
IL197130A0 (en) 2009-11-18
BRPI0715835A2 (pt) 2013-07-23
TW200816998A (en) 2008-04-16
AU2007287560A1 (en) 2008-02-28
WO2008023027A2 (fr) 2008-02-28
AR062509A1 (es) 2008-11-12

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