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WO2008022365A3 - Agent servant à influencer les effets de composés organophosphorés et utilisation de galanthamine, de ses dérivés et analogues pour la fabrication d'un tel agent - Google Patents

Agent servant à influencer les effets de composés organophosphorés et utilisation de galanthamine, de ses dérivés et analogues pour la fabrication d'un tel agent Download PDF

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Publication number
WO2008022365A3
WO2008022365A3 PCT/AT2007/000404 AT2007000404W WO2008022365A3 WO 2008022365 A3 WO2008022365 A3 WO 2008022365A3 AT 2007000404 W AT2007000404 W AT 2007000404W WO 2008022365 A3 WO2008022365 A3 WO 2008022365A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
galanthamine
analogues
derivatives
influencing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AT2007/000404
Other languages
German (de)
English (en)
Other versions
WO2008022365A2 (fr
Inventor
Werner Frantsits
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanochemia Ltd
Original Assignee
Sanochemia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanochemia Ltd filed Critical Sanochemia Ltd
Publication of WO2008022365A2 publication Critical patent/WO2008022365A2/fr
Anticipated expiration legal-status Critical
Publication of WO2008022365A3 publication Critical patent/WO2008022365A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne l'utilisation de galanthamine de formule (I) et de dérivés ou d'analogues de galanthamine pour lutter contre les effets de composés de phosphore organiques toxiques, tels que la parathione, la paraxone, le sarin, le soman ou le tabun. Selon l'invention, un agent contenant ledit composé ou une combinaison d'au moins deux desdits composés est administré avant et/ou après le contact d'un humain avec le composé de phosphore organique toxique.
PCT/AT2007/000404 2006-08-24 2007-08-23 Agent servant à influencer les effets de composés organophosphorés et utilisation de galanthamine, de ses dérivés et analogues pour la fabrication d'un tel agent Ceased WO2008022365A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ATA1417/2006 2006-08-24
AT14172006 2006-08-24

Publications (2)

Publication Number Publication Date
WO2008022365A2 WO2008022365A2 (fr) 2008-02-28
WO2008022365A3 true WO2008022365A3 (fr) 2009-04-09

Family

ID=39107152

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AT2007/000404 Ceased WO2008022365A2 (fr) 2006-08-24 2007-08-23 Agent servant à influencer les effets de composés organophosphorés et utilisation de galanthamine, de ses dérivés et analogues pour la fabrication d'un tel agent

Country Status (1)

Country Link
WO (1) WO2008022365A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9132135B2 (en) * 2004-09-24 2015-09-15 University Of Maryland, Baltimore Method of treating organophosphorous poisoning
BG110141A (en) * 2008-05-23 2009-12-31 "Софарма" Ад GALANTAMINE DERIVATIVES, METHODS FOR THEIR PREPARATION AND USE
RU2404160C1 (ru) * 2009-06-01 2010-11-20 Федеральное государственное учреждение "33 Центральный научно-исследовательский испытательный институт Министерства обороны Российской Федерации"(ФГУ "33 ЦНИИИ МО РФ") Применение n,n-диэтиланилина в качестве имитатора зомана в водной среде
WO2013160728A1 (fr) 2012-04-26 2013-10-31 Alma Mater Studiorum - Universita' Di Bologna Composés à double ciblage pour le traitement de la maladie d'alzheimer
CN104860955B (zh) * 2015-04-22 2017-07-14 华东理工大学 加兰他敏类似物及其用途
CN118908968B (zh) * 2024-10-09 2025-03-04 威胜生物医药(苏州)股份有限公司 一种加兰他敏中间体衍生物及其催化氧化制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4342174C1 (de) * 1993-12-10 1995-05-11 Lohmann Therapie Syst Lts Transdermales therapeutisches System sowie ein Verfahren zur Herstellung eines transdermalen therapeutischen Systems zur kombinierten transdermalen Anwendung von Physostigmin und Scopolamin für die Prophylaxe und zur Vorbehandlung einer Vergiftung durch hochtoxische phosphororganische Nervengifte, insbesondere Soman und seine Verwendung
US20030199493A1 (en) * 2000-03-31 2003-10-23 Ulrich Jordis Novel derivatives and analogues of galanthamin
US20050013869A1 (en) * 2003-07-18 2005-01-20 Chaw Cheng Shu Sustained release formulation for carbamates and a method therefor
WO2005030333A2 (fr) * 2003-09-29 2005-04-07 Sanochemia Pharmazeutika Ag Nouveaux derives de 4a,5,9,10,11,12-hexahydrobenzofuro[3a,3,2] [2]- benzazepine, procede pour les preparer et leur utilisation pour la preparation de produits pharmaceutiques
WO2005030332A2 (fr) * 2003-09-29 2005-04-07 Sanochemia Pharmazeutika Ag Utilisation de galanthamine et de ses derives pour preparer des produits pharmaceutiques
WO2006036686A2 (fr) * 2004-09-24 2006-04-06 University Of Maryland, Baltimore Methode destinee a traiter une intoxication par un organophosphore

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4342174C1 (de) * 1993-12-10 1995-05-11 Lohmann Therapie Syst Lts Transdermales therapeutisches System sowie ein Verfahren zur Herstellung eines transdermalen therapeutischen Systems zur kombinierten transdermalen Anwendung von Physostigmin und Scopolamin für die Prophylaxe und zur Vorbehandlung einer Vergiftung durch hochtoxische phosphororganische Nervengifte, insbesondere Soman und seine Verwendung
US20030199493A1 (en) * 2000-03-31 2003-10-23 Ulrich Jordis Novel derivatives and analogues of galanthamin
US20050013869A1 (en) * 2003-07-18 2005-01-20 Chaw Cheng Shu Sustained release formulation for carbamates and a method therefor
WO2005030333A2 (fr) * 2003-09-29 2005-04-07 Sanochemia Pharmazeutika Ag Nouveaux derives de 4a,5,9,10,11,12-hexahydrobenzofuro[3a,3,2] [2]- benzazepine, procede pour les preparer et leur utilisation pour la preparation de produits pharmaceutiques
WO2005030332A2 (fr) * 2003-09-29 2005-04-07 Sanochemia Pharmazeutika Ag Utilisation de galanthamine et de ses derives pour preparer des produits pharmaceutiques
WO2006036686A2 (fr) * 2004-09-24 2006-04-06 University Of Maryland, Baltimore Methode destinee a traiter une intoxication par un organophosphore

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ALBUQUERQUE E X ET AL: "Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 20060829 US, vol. 103, no. 35, 16 August 2006 (2006-08-16), pages 13220 - 13225, XP002513372, ISSN: 0027-8424 *
TONKOPII V D: "Oxidative stress in the mechanism of organophosphates neurotoxicity", TOXICOLOGY LETTERS, ELSEVIER BIOMEDICAL PRESS, AMSTERDAM, NL, vol. 144, no. Suppl, 1 September 2003 (2003-09-01), pages s132, XP009109279, ISSN: 0378-4274 *

Also Published As

Publication number Publication date
WO2008022365A2 (fr) 2008-02-28

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