[go: up one dir, main page]

WO2008021439A3 - Compositions and methods for treatment of cardiac hypertrophy - Google Patents

Compositions and methods for treatment of cardiac hypertrophy Download PDF

Info

Publication number
WO2008021439A3
WO2008021439A3 PCT/US2007/018147 US2007018147W WO2008021439A3 WO 2008021439 A3 WO2008021439 A3 WO 2008021439A3 US 2007018147 W US2007018147 W US 2007018147W WO 2008021439 A3 WO2008021439 A3 WO 2008021439A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
treatment
cardiac hypertrophy
compositions
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/018147
Other languages
French (fr)
Other versions
WO2008021439A2 (en
Inventor
Andrew Robert Marks
Stephan E Lehnart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Columbia University in the City of New York
Original Assignee
Columbia University in the City of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/506,285 external-priority patent/US7879840B2/en
Priority claimed from PCT/US2006/032405 external-priority patent/WO2007024717A2/en
Application filed by Columbia University in the City of New York filed Critical Columbia University in the City of New York
Publication of WO2008021439A2 publication Critical patent/WO2008021439A2/en
Publication of WO2008021439A3 publication Critical patent/WO2008021439A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

The present invention provides methods and compositions useful for the treatment and/or prevention of cardiac hypertrophy. In certain embodiments, the methods of the present invention comprise administering to a subject a therapeutically or prophylactically effective amount of a 1,4, benzothiazepine compound.
PCT/US2007/018147 2006-08-17 2007-08-15 Compositions and methods for treatment of cardiac hypertrophy Ceased WO2008021439A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US11/506,285 US7879840B2 (en) 2005-08-25 2006-08-17 Agents for preventing and treating disorders involving modulation of the RyR receptors
USPCT/US2006/32405 2006-08-17
PCT/US2006/032405 WO2007024717A2 (en) 2005-08-25 2006-08-17 Agents for preventing and treating disorders involving modulation of the ryr receptors
US11/506,285 2006-08-17
US90434907P 2007-02-28 2007-02-28
US60/904,349 2007-02-28
US80947007A 2007-06-01 2007-06-01
US11/809,470 2007-06-01

Publications (2)

Publication Number Publication Date
WO2008021439A2 WO2008021439A2 (en) 2008-02-21
WO2008021439A3 true WO2008021439A3 (en) 2008-11-20

Family

ID=39082735

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/018147 Ceased WO2008021439A2 (en) 2006-08-17 2007-08-15 Compositions and methods for treatment of cardiac hypertrophy

Country Status (1)

Country Link
WO (1) WO2008021439A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
EP2708535A1 (en) * 2012-05-11 2014-03-19 Les Laboratoires Servier Agents for treating disorders involving modulation of ryanodine receptors
US11504383B2 (en) 2021-01-08 2022-11-22 Armgo Pharma, Inc. Crystalline forms of a Ryanodine receptor modulator and uses thereof
US11717526B2 (en) 2021-05-20 2023-08-08 Armgo Pharma, Inc. Pharmaceutical compositions comprising a ryanodine receptor modulator and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050187386A1 (en) * 2002-11-05 2005-08-25 Andrew Robert Marks Novel anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
US7312044B2 (en) * 2003-03-07 2007-12-25 The Trustees Of Columbia University In The City Of New York Type 1 ryanodine receptor-based methods
US7393652B2 (en) * 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7393652B2 (en) * 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US20050187386A1 (en) * 2002-11-05 2005-08-25 Andrew Robert Marks Novel anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
US7312044B2 (en) * 2003-03-07 2007-12-25 The Trustees Of Columbia University In The City Of New York Type 1 ryanodine receptor-based methods

Also Published As

Publication number Publication date
WO2008021439A2 (en) 2008-02-21

Similar Documents

Publication Publication Date Title
WO2009027820A3 (en) Substituted-quinoxaline-type-piperidine compounds and the uses thereof
WO2007120980A3 (en) 2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases
WO2008092006A3 (en) Antimicrobial compositions
WO2008070129A3 (en) Compositions and methods for the treatment of inflammatory disease
MX2009000657A (en) Compositions and methods for the treatment of mucositis.
WO2009064388A3 (en) Inhibitors of human methionine aminopeptidase 1 and methods of treating disorders
WO2007146965A3 (en) Compounds for the treatment of periodontal disease
IL193252A0 (en) N-hydroxyacrylamide compounds
WO2007112272A3 (en) Formulations of low dose diclofenac and beta-cyclodextrin
IL187565A0 (en) Compositions and methods for the treatment or prevention of chemoresistant neoplasia
WO2007100561A3 (en) Use of dha and ara in the preparation of a composition for preventing or treating obesity
WO2008047061A3 (en) Cosmetic oral and/or parenteral use of glucosamine optionally in combination with at least one polyphenol compound, and corresponding composition
WO2008016640A3 (en) Use of poloxamer for the prevention and/or treatment of heart failure
WO2006128143A3 (en) Hydantoin compounds
WO2010062506A3 (en) Decahydro-1h-indenoquinolinone and decahydro-3h-cyclopentaphenanthridinone cyp17 inhibitors
NO20083901L (en) Fixed-dose association of phytate and zinc
WO2008021439A3 (en) Compositions and methods for treatment of cardiac hypertrophy
EP2056830A4 (en) Compositions useful especially for treatment or prevention of metabolic syndrome
WO2007075923A3 (en) Treatment of synucleinopathies
WO2007139833A3 (en) Imidazoazephinone compounds
WO2007115287A3 (en) Combination of organic compounds
WO2008022807A3 (en) Lipoxin a4 analogs for the treatment and prevention of intestinal fibrosis
WO2007095609A3 (en) Use of benzo-heteroaryl sulfamide derivatives for the treatment of mania and bipolar disorder
WO2006121995A3 (en) Methods for treating nephrolithiasis
WO2009158387A3 (en) Compositions, formulations, and methods for preventing and/or treating physical effects of alcohol consumption

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07811368

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

NENP Non-entry into the national phase

Ref country code: RU

122 Ep: pct application non-entry in european phase

Ref document number: 07811368

Country of ref document: EP

Kind code of ref document: A2