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WO2008016385A3 - Deacylase polypeptides, deacylase polynucleotides, and methods of use thereof - Google Patents

Deacylase polypeptides, deacylase polynucleotides, and methods of use thereof Download PDF

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Publication number
WO2008016385A3
WO2008016385A3 PCT/US2007/001290 US2007001290W WO2008016385A3 WO 2008016385 A3 WO2008016385 A3 WO 2008016385A3 US 2007001290 W US2007001290 W US 2007001290W WO 2008016385 A3 WO2008016385 A3 WO 2008016385A3
Authority
WO
WIPO (PCT)
Prior art keywords
deacylase
present
methods
polypeptides
invention further
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/001290
Other languages
French (fr)
Other versions
WO2008016385A2 (en
Inventor
Richard P Darveau
Stephen R Coats
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Original Assignee
University of Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington filed Critical University of Washington
Publication of WO2008016385A2 publication Critical patent/WO2008016385A2/en
Anticipated expiration legal-status Critical
Publication of WO2008016385A3 publication Critical patent/WO2008016385A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides isolated deacylase polypeptides; and deacylase nucleic acids. The present invention further provides methods for identifying inhibitors of a bacterial deacylase and that are candidates for treating a periodontal disease. The present invention further provides antibodies specific for a subject deacylase polypeptide. The present invention further provides diagnostic methods for detecting silent bacterial infections of the gum tissues; diagnostic methods for detecting conditions and disorders that are sequelae of periodontitis; and diagnostic methods for monitoring a patient's response to treatment for a periodontal disease.
PCT/US2007/001290 2006-01-20 2007-01-18 Deacylase polypeptides, deacylase polynucleotides, and methods of use thereof Ceased WO2008016385A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76055606P 2006-01-20 2006-01-20
US60/760,556 2006-01-20

Publications (2)

Publication Number Publication Date
WO2008016385A2 WO2008016385A2 (en) 2008-02-07
WO2008016385A3 true WO2008016385A3 (en) 2009-01-08

Family

ID=38997606

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/001290 Ceased WO2008016385A2 (en) 2006-01-20 2007-01-18 Deacylase polypeptides, deacylase polynucleotides, and methods of use thereof

Country Status (1)

Country Link
WO (1) WO2008016385A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO652897A0 (en) 1997-04-30 1997-05-29 University Of Melbourne, The Synthetic peptide constructs for the diagnosis and treatment of periodontitis
US8129500B2 (en) 1997-12-10 2012-03-06 Csl Limited Porphyromonas gingivalis polypeptides and nucleotides
AU2007264402B2 (en) 2006-06-27 2012-09-20 Oral Health Australia Pty Ltd Porphyromonas gingivalis polypeptides useful in the prevention of periodontal disease
EP2638905B1 (en) 2007-07-12 2019-01-16 Oral Health Australia Pty Ltd Biofilm treatment
AU2013203250B2 (en) * 2007-07-12 2014-11-13 Oral Health Australia Pty Ltd Immunology treatment for biofilms
US20100297179A1 (en) * 2007-07-12 2010-11-25 Stuart Geoffrey Dashper Immunology Treatment for Biofilms
BRPI0917321A2 (en) 2008-08-29 2015-11-17 Oral Health Australia Pty Ltd prevention, treatment and diagnosis of p. gingivalis
WO2020139784A1 (en) * 2018-12-29 2020-07-02 Weinberg Assa Method to prevent and treat gingival recession by calcium channel blockers, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712102A (en) * 1993-11-10 1998-01-27 Bristol-Myers Squibb Company Method of screening compounds which inhibit P. gingivalis lipopolysaccharide from inhibiting the extravasation of leukocytes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712102A (en) * 1993-11-10 1998-01-27 Bristol-Myers Squibb Company Method of screening compounds which inhibit P. gingivalis lipopolysaccharide from inhibiting the extravasation of leukocytes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] NELSON ET AL., Database accession no. (NP_906066) *

Also Published As

Publication number Publication date
WO2008016385A2 (en) 2008-02-07

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