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WO2008014249A3 - Improved preparations of 2 -substituted pyrrolo [2, 3-b] pyrazine ( 4, 7 -diazaindole ) compounds - Google Patents

Improved preparations of 2 -substituted pyrrolo [2, 3-b] pyrazine ( 4, 7 -diazaindole ) compounds Download PDF

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Publication number
WO2008014249A3
WO2008014249A3 PCT/US2007/074202 US2007074202W WO2008014249A3 WO 2008014249 A3 WO2008014249 A3 WO 2008014249A3 US 2007074202 W US2007074202 W US 2007074202W WO 2008014249 A3 WO2008014249 A3 WO 2008014249A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
diazaindole
pyrazine
substituted pyrrolo
improved preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/074202
Other languages
French (fr)
Other versions
WO2008014249A2 (en
Inventor
Danette Astolfi
Timothy Allen Ayers
Sithamalli V Chandramouli
Andrea Hillegass
Gregory G Kubiak
George Everett Lee
David J Lythgoe
Matthew R Powers
Witold Subotkowski
Benoit VANASSE
Franz J Weiberth
Yong Yu
Boris Gordonov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Publication of WO2008014249A2 publication Critical patent/WO2008014249A2/en
Publication of WO2008014249A3 publication Critical patent/WO2008014249A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Improved methods for making 2-substituted pyrrolo [2, 3-b] pyrazines (azaindoles) and related compounds are disclosed.
PCT/US2007/074202 2006-07-24 2007-07-24 Improved preparations of 2 -substituted pyrrolo [2, 3-b] pyrazine ( 4, 7 -diazaindole ) compounds Ceased WO2008014249A2 (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US82013806P 2006-07-24 2006-07-24
US82014906P 2006-07-24 2006-07-24
US82014806P 2006-07-24 2006-07-24
US82016206P 2006-07-24 2006-07-24
US82016006P 2006-07-24 2006-07-24
US60/820,162 2006-07-24
US60/820,149 2006-07-24
US60/820,160 2006-07-24
US60/820,148 2006-07-24
US60/820,138 2006-07-24

Publications (2)

Publication Number Publication Date
WO2008014249A2 WO2008014249A2 (en) 2008-01-31
WO2008014249A3 true WO2008014249A3 (en) 2008-12-11

Family

ID=38858928

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/074202 Ceased WO2008014249A2 (en) 2006-07-24 2007-07-24 Improved preparations of 2 -substituted pyrrolo [2, 3-b] pyrazine ( 4, 7 -diazaindole ) compounds

Country Status (1)

Country Link
WO (1) WO2008014249A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008052943A1 (en) 2008-10-23 2010-04-29 Merck Patent Gmbh azaindole derivatives
DE102013014881B4 (en) 2012-09-12 2023-05-04 Fairchild Semiconductor Corporation Enhanced silicon via with multi-material fill
WO2022231263A1 (en) * 2021-04-27 2022-11-03 주식회사 엘지화학 Method for preparing intermediate for synthesis of xanthine oxidase inhibitor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6770643B2 (en) * 1999-12-24 2004-08-03 Aventis Pharma Limited Azaindoles

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6770643B2 (en) * 1999-12-24 2004-08-03 Aventis Pharma Limited Azaindoles

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHRISTOPHER KORADIN ET AL: "Synthesis of polyfunctional indoles and related heterocycles mediated by cesium and potassium bases", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 59, no. 9, 24 February 2003 (2003-02-24), pages 1571 - 1587, XP004409958, ISSN: 0040-4020 *
COREY R. HOPKINS AND NICOLA COLLAR: "6-Substituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation from N-(3-chloropyrazin-2-yl)methane- sulfonamide and alkynes", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, vol. 45, no. 43, 18 October 2004 (2004-10-18), pages 8087 - 8090, XP004584133, ISSN: 0040-4039 *
MATTHEW J. MIO ET AL: "One-pot synthesis of symmetrical and unsymmetrical bisarylethynes by a modification of the Sonogashira coupling reaction", ORGANIC LETTERS, vol. 4, no. 19, 2002, pages 3199 - 3202, XP002482923 *
MICHAEL L. DAVIS ET AL: "Reactions of beta-(lithiomethyl)azines with nitriles as a route to pyrrolo-pyridines, -quinolines, -pyrazines, -quinoxalines and -pyrimidines", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 48, no. 5, 1 January 1992 (1992-01-01), pages 939 - 952, XP001118259, ISSN: 0040-4020 *
YVETTE METTEY ET AL: "Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects", JOURNAL OF MEDICINAL CHEMISTRY, US AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 46, no. 2, 18 December 2002 (2002-12-18), pages 222 - 236, XP002285187, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
WO2008014249A2 (en) 2008-01-31

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