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WO2008014054A3 - Bmp-7 variant compositions, methods and uses - Google Patents

Bmp-7 variant compositions, methods and uses Download PDF

Info

Publication number
WO2008014054A3
WO2008014054A3 PCT/US2007/070584 US2007070584W WO2008014054A3 WO 2008014054 A3 WO2008014054 A3 WO 2008014054A3 US 2007070584 W US2007070584 W US 2007070584W WO 2008014054 A3 WO2008014054 A3 WO 2008014054A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
bmp
variant compositions
peptide chains
variant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/070584
Other languages
French (fr)
Other versions
WO2008014054A2 (en
Inventor
Bernard Amegadzie
Mark R Cunningham
Haimanti Dorai
Jeffrey Luo
Juliane Mills
Bethany Swencki-Underwood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Biotech Inc
Original Assignee
Centocor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc filed Critical Centocor Inc
Priority to EP07798210A priority Critical patent/EP2056852A4/en
Priority to JP2009521874A priority patent/JP2009544325A/en
Publication of WO2008014054A2 publication Critical patent/WO2008014054A2/en
Anticipated expiration legal-status Critical
Publication of WO2008014054A3 publication Critical patent/WO2008014054A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Human Bone Morphogenic Protein 7 (hBMP-7) variant peptide chains, nucleic acids encoding these peptide chains, and methods of making and using the foregoing are disclosed.
PCT/US2007/070584 2006-07-27 2007-06-07 Bmp-7 variant compositions, methods and uses Ceased WO2008014054A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07798210A EP2056852A4 (en) 2006-07-27 2007-06-07 Bmp-7 variant compositions, methods and uses
JP2009521874A JP2009544325A (en) 2006-07-27 2007-06-07 BMP-7 variant compositions, methods and uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82053806P 2006-07-27 2006-07-27
US60/820,538 2006-07-27

Publications (2)

Publication Number Publication Date
WO2008014054A2 WO2008014054A2 (en) 2008-01-31
WO2008014054A3 true WO2008014054A3 (en) 2009-04-09

Family

ID=38982164

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/070584 Ceased WO2008014054A2 (en) 2006-07-27 2007-06-07 Bmp-7 variant compositions, methods and uses

Country Status (3)

Country Link
EP (1) EP2056852A4 (en)
JP (1) JP2009544325A (en)
WO (1) WO2008014054A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101274930B1 (en) * 2011-06-03 2013-06-17 전남대학교산학협력단 Bone forming peptide 4 for promoting osteogenesis or vascularization and use thereof
KR101279145B1 (en) * 2012-08-10 2013-06-26 주식회사 셀루메드 Method for increasing production rate of active form of bmp7
GB201412290D0 (en) 2014-07-10 2014-08-27 Cambridge Entpr Ltd Novel use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5641649A (en) * 1992-01-27 1997-06-24 Italian Ministry For Universities And Scientific And Technological Research Expression of osteogenic factor OP-1 in cells of spodoptera frugiperda infected with recombinant baculovirus

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69333745T2 (en) * 1992-07-31 2005-12-29 Stryker Corp., Kalamazoo SOLUBLE COMPLEX OF MORPHOGENIC PROTEINS AND COMPOSITIONS THEREOF
ES2297889T3 (en) * 1997-07-14 2008-05-01 Bolder Biotechnology, Inc. DERIVATIVES OF HORMONE OF GROWTH AND RELATED PROTEINS.
US20030170213A1 (en) * 1998-01-23 2003-09-11 Marc F. Charette Methods and compositions for enhancing cognitive function using morphogenic proteins
US6677432B1 (en) * 1998-10-07 2004-01-13 Stryker Corporation Mutations of the C-terminal portion of TGF-β superfamily proteins
US7610156B2 (en) * 2003-03-31 2009-10-27 Xencor, Inc. Methods for rational pegylation of proteins
CA2561809A1 (en) * 2004-03-31 2005-10-20 Xencor, Inc. Bmp-7 variants with improved properties
ATE543833T1 (en) * 2005-12-22 2012-02-15 Janssen Biotech Inc BMP-7 VARIANT COMPOSITIONS, METHODS AND USES

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5641649A (en) * 1992-01-27 1997-06-24 Italian Ministry For Universities And Scientific And Technological Research Expression of osteogenic factor OP-1 in cells of spodoptera frugiperda infected with recombinant baculovirus

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2056852A4 *

Also Published As

Publication number Publication date
JP2009544325A (en) 2009-12-17
EP2056852A4 (en) 2010-01-13
EP2056852A2 (en) 2009-05-13
WO2008014054A2 (en) 2008-01-31

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