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WO2008011625A3 - Dispositifs à micro-aiguille(s) et procédés d'administration de médicament ou de retrait de fluide - Google Patents

Dispositifs à micro-aiguille(s) et procédés d'administration de médicament ou de retrait de fluide Download PDF

Info

Publication number
WO2008011625A3
WO2008011625A3 PCT/US2007/074123 US2007074123W WO2008011625A3 WO 2008011625 A3 WO2008011625 A3 WO 2008011625A3 US 2007074123 W US2007074123 W US 2007074123W WO 2008011625 A3 WO2008011625 A3 WO 2008011625A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
microneedle devices
drug delivery
drug
base substrate
Prior art date
Application number
PCT/US2007/074123
Other languages
English (en)
Other versions
WO2008011625A2 (fr
Inventor
Mark R Prausnitz
Jeong Woo Lee
Original Assignee
Georgia Tech Researh Corp
Mark R Prausnitz
Jeong Woo Lee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgia Tech Researh Corp, Mark R Prausnitz, Jeong Woo Lee filed Critical Georgia Tech Researh Corp
Publication of WO2008011625A2 publication Critical patent/WO2008011625A2/fr
Publication of WO2008011625A3 publication Critical patent/WO2008011625A3/fr
Priority to US12/357,195 priority Critical patent/US20090182306A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
    • B81C1/00111—Tips, pillars, i.e. raised structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/055—Microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C2201/00—Manufacture or treatment of microstructural devices or systems
    • B81C2201/03—Processes for manufacturing substrate-free structures
    • B81C2201/034—Moulding

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L'invention concerne des dispositifs à micro-aiguille(s) et des procédés de fabrication et d'utilisation de ceux-ci. Dans un mode de réalisation, l'invention concerne un dispositif permettant la libération prolongée d'un médicament à travers ou dans une barrière biologique telle que la peau. Ce dispositif peut comporter un substrat de base comprenant un médicament dispersé dans une matière de matrice, et une ou plusieurs micro-aiguilles s'étendant à partir du substrat de base, la ou les micro-aiguilles comportant une matière soluble ou gonflable dans l'eau, matière grâce à laquelle la ou les micro-aiguilles se dissolvent ou gonflent après avoir été introduites dans la barrière biologique, permettant ainsi le passage du médicament du substrat de base dans la barrière biologique.
PCT/US2007/074123 2006-07-21 2007-07-23 Dispositifs à micro-aiguille(s) et procédés d'administration de médicament ou de retrait de fluide WO2008011625A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/357,195 US20090182306A1 (en) 2006-07-21 2009-01-21 Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83247906P 2006-07-21 2006-07-21
US60/832,479 2006-07-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/357,195 Continuation-In-Part US20090182306A1 (en) 2006-07-21 2009-01-21 Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal

Publications (2)

Publication Number Publication Date
WO2008011625A2 WO2008011625A2 (fr) 2008-01-24
WO2008011625A3 true WO2008011625A3 (fr) 2008-12-04

Family

ID=38957686

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/074123 WO2008011625A2 (fr) 2006-07-21 2007-07-23 Dispositifs à micro-aiguille(s) et procédés d'administration de médicament ou de retrait de fluide

Country Status (1)

Country Link
WO (1) WO2008011625A2 (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
US20080213461A1 (en) 2005-06-17 2008-09-04 Georgia Tech Research Corporation Coated Microstructures and Methods of Manufacture Thereof
US7699819B2 (en) 2006-02-21 2010-04-20 The Hong Kong University Of Science And Technology Molecular sieve and zeolite microneedles and preparation thereof
CA2676221C (fr) 2007-01-22 2016-12-20 Corium International, Inc. Applicateurs pour micro-aiguilles
ES2820335T3 (es) 2007-04-16 2021-04-20 Corium Inc Matrices de microagujas coladas con disolvente que contienen agente activo
AU2014200648B2 (en) * 2007-04-16 2015-09-24 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
CN101808588B (zh) 2007-09-28 2012-12-19 贝尔法斯特女王大学 递送装置及方法
WO2009048607A1 (fr) 2007-10-10 2009-04-16 Corium International, Inc. Distribution de vaccin par l'intermédiaire de réseaux de micro-aiguilles
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
US9220678B2 (en) 2007-12-24 2015-12-29 The University Of Queensland Coating method
WO2009097660A1 (fr) 2008-02-07 2009-08-13 The University Of Queensland Fabrication de timbre transdermique
US8398397B2 (en) 2008-03-12 2013-03-19 Ultradent Products, Inc. Dental intraligamentary injection needles and related methods of manufacture
ES2687258T3 (es) * 2008-05-21 2018-10-24 Theraject, Inc. Procedimiento de fabricación de conjuntos de microagujas
AU2009250341A1 (en) 2008-05-23 2009-11-26 The University Of Queensland Analyte detection using a needle projection patch
EP2346563B1 (fr) * 2008-10-07 2018-08-29 Tuo Jin Micro-aiguilles polymères à transition de phase
WO2010071918A1 (fr) * 2008-12-22 2010-07-01 The University Of Queensland Production de pièce
WO2011140274A2 (fr) 2010-05-04 2011-11-10 Corium International, Inc. Méthode et dispositif permettant l'administration transdermique d'hormone parathyroïdienne au moyen d'un réseau de microprojections
WO2012006677A1 (fr) 2010-07-14 2012-01-19 The University Of Queensland Appareil d'application de timbre transdermique
JP5770055B2 (ja) * 2010-09-29 2015-08-26 富士フイルム株式会社 針状アレイ経皮吸収シートの製造方法
GB201107642D0 (en) * 2011-05-09 2011-06-22 Univ Cork Method
EP2765927B1 (fr) 2011-10-12 2021-02-24 Vaxxas Pty Limited Dispositif de distribution
BR112015014969B1 (pt) * 2012-12-21 2021-12-07 Corium, Inc Aparelho de microestruturas e método de fabricar um aparelho de microestruturas
RU2679107C2 (ru) * 2013-01-21 2019-02-05 Пхэан Эстетикс Инк. Микроигла, форма для ее изготовления и способ изготовления микроиглы
EP2968887B1 (fr) 2013-03-12 2022-05-04 Corium, Inc. Applicateurs de microprojection
AU2014233541B2 (en) 2013-03-15 2018-11-22 Corium Pharma Solutions, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
BR112015022625B1 (pt) 2013-03-15 2023-01-31 Corium, Inc Aparelho de microestrutura para entrega de agente terapêutico
CA2903763C (fr) 2013-03-15 2021-11-16 Corium International, Inc. Micro-reseau ayant des microstructures sans polymere, procedes de fabrication et procedes d'utilisation
ES2939317T3 (es) 2013-03-15 2023-04-20 Corium Pharma Solutions Inc Aplicadores de microproyección de impacto múltiple
CN106573155A (zh) 2014-02-26 2017-04-19 鲁玛治疗公司 紫外光疗设备和方法
WO2015151516A1 (fr) * 2014-04-03 2015-10-08 凸版印刷株式会社 Instrument d'injection ponction
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
US11147954B2 (en) 2015-02-02 2021-10-19 Vaxxas Pty Limited Microprojection array applicator and method
EP3285750B1 (fr) * 2015-04-21 2020-10-21 North Carolina State University Système d'administration d'insuline répondant au glucose utilisant des nanocomposites sensibles à l'hypoxie
WO2017004067A1 (fr) 2015-06-29 2017-01-05 Corium International, Inc. Micro-réseau pour l'administration d'un agent thérapeutique, procédés d'utilisation, et procédés de fabrication
WO2017045031A1 (fr) 2015-09-18 2017-03-23 Vaxxas Pty Limited Réseaux de micro-saillies comportant des micro-saillies ayant des profils à surface élevée
EP3355981A4 (fr) 2015-09-28 2019-05-22 Vaxxas Pty Limited Réseau de microsaillies ayant des propriétés de pénétration de la peau améliorées et procédés associés
US11103387B2 (en) * 2016-01-13 2021-08-31 The General Hospital Corporation Systems and methods for removing exogenous particles from the skin of a patient
JP2019511343A (ja) 2016-02-09 2019-04-25 ルマ セラピューティクス, インク.Luma Therapeutics, Inc. 光線療法による乾癬処置の方法と組成物と装置
WO2018176102A1 (fr) 2017-03-31 2018-10-04 Vaxxas Pty Limited Dispositif et procédé de revêtement de surfaces
WO2018227246A1 (fr) 2017-06-13 2018-12-20 Vaxxas Pty Limited Contrôle de la qualité de revêtements de substrats
CA3071680A1 (fr) 2017-08-04 2019-02-07 Vaxxas Pty Limited Actionneur a stockage d'energie mecanique eleve compact et a force de declenchement faible pour l'administration de patchs a reseaux de microprojections (prm)
CN108837238B (zh) * 2018-07-13 2023-09-01 江苏省人民医院（南京医科大学第一附属医院） 一种玻尿酸注射针
CN111588689B (zh) * 2020-06-20 2023-08-11 温州医科大学 一种角膜微创可溶性微针贴片及其制备方法与应用
US20220105029A1 (en) * 2020-10-07 2022-04-07 The Board Of Trustees Of The University Of Arkansas Biodegradable chitosan microneedle patch for transdermal delivery for livestock pain management
WO2022174040A1 (fr) * 2021-02-11 2022-08-18 10X Technology Llc Procédé et appareil de fabrication de micro-aiguille cassante
US20240149033A1 (en) * 2021-02-27 2024-05-09 The Brigham And Women`S Hospital, Inc. Microneedle compositions and methods of delivery using the same

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US20020177839A1 (en) * 2001-04-20 2002-11-28 Cormier Michel J. N. Microprojection array having a beneficial agent containing coating

Patent Citations (2)

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US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US20020177839A1 (en) * 2001-04-20 2002-11-28 Cormier Michel J. N. Microprojection array having a beneficial agent containing coating

Also Published As

Publication number Publication date
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