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WO2008010231A3 - A process for the purification of topiramate - Google Patents

A process for the purification of topiramate Download PDF

Info

Publication number
WO2008010231A3
WO2008010231A3 PCT/IN2007/000211 IN2007000211W WO2008010231A3 WO 2008010231 A3 WO2008010231 A3 WO 2008010231A3 IN 2007000211 W IN2007000211 W IN 2007000211W WO 2008010231 A3 WO2008010231 A3 WO 2008010231A3
Authority
WO
WIPO (PCT)
Prior art keywords
topiramate
purification
aqueous alkali
alkali solution
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2007/000211
Other languages
French (fr)
Other versions
WO2008010231A2 (en
Inventor
Pandurang Balwant Deshpande
Parven Kumar Luthra
Anand Kumar Pandey
Dinesh Jayantibhai Paghdar
Bhavinkumar Prafulbha Hamirani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alembic Ltd
Original Assignee
Alembic Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alembic Ltd filed Critical Alembic Ltd
Publication of WO2008010231A2 publication Critical patent/WO2008010231A2/en
Publication of WO2008010231A3 publication Critical patent/WO2008010231A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)

Abstract

The present invention provides a process for the purification of Topiramate comprising treating Topiramate with aqueous alkali solution followed by washing the aqueous alkali solution of Topiramate with water immiscible solvent and neutralizing this solution to obtain Topiramate having purity at least 99% impurity of formula (II) less than 0.1%.
PCT/IN2007/000211 2006-05-26 2007-05-23 A process for the purification of topiramate Ceased WO2008010231A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN810MU2006 2006-05-26
IN810/MUM/2006 2006-05-26

Publications (2)

Publication Number Publication Date
WO2008010231A2 WO2008010231A2 (en) 2008-01-24
WO2008010231A3 true WO2008010231A3 (en) 2008-05-29

Family

ID=38957201

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000211 Ceased WO2008010231A2 (en) 2006-05-26 2007-05-23 A process for the purification of topiramate

Country Status (1)

Country Link
WO (1) WO2008010231A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
CN106632530A (en) * 2016-12-08 2017-05-10 陕西大生制药科技有限公司 Preparation method of high-purity topiramate
CN110655542A (en) * 2018-06-29 2020-01-07 鲁南制药集团股份有限公司 Crystal form of 2,3:4, 5-bis-O- (1-methylethylidene) -beta-D-fructopyranose chlorosulfonate
CN113651861A (en) * 2020-05-12 2021-11-16 鲁南制药集团股份有限公司 Topiramate impurity
CN113999228B (en) * 2021-11-08 2022-11-04 南京卓康医药科技有限公司 Synthesis method of tadalafil

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0138441A2 (en) * 1983-09-26 1985-04-24 McNeilab, Inc. Anticonvulsant sulfamate derivatives
WO2004078769A1 (en) * 2003-03-04 2004-09-16 Ortho-Mcneil Pharmaceutical Inc. Process for the preparation of anticonvulsant derivatives of topiramate
WO2004108732A1 (en) * 2003-05-12 2004-12-16 Sun Pharmaceutical Industries Limited PROCESS FOR THE PREPARATION OF 2,3:4,5-BIS-O(1-METHYLETHYLIDENE)-ß-D-FRUCTOPYRANOSE SULFAMATE

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0138441A2 (en) * 1983-09-26 1985-04-24 McNeilab, Inc. Anticonvulsant sulfamate derivatives
WO2004078769A1 (en) * 2003-03-04 2004-09-16 Ortho-Mcneil Pharmaceutical Inc. Process for the preparation of anticonvulsant derivatives of topiramate
WO2004108732A1 (en) * 2003-05-12 2004-12-16 Sun Pharmaceutical Industries Limited PROCESS FOR THE PREPARATION OF 2,3:4,5-BIS-O(1-METHYLETHYLIDENE)-ß-D-FRUCTOPYRANOSE SULFAMATE

Also Published As

Publication number Publication date
WO2008010231A2 (en) 2008-01-24

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