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WO2008010096A3 - Method for preparing recombinant mycobacterial polypeptides in yeast and their use in diagnosis of mycobacterial related diseases - Google Patents

Method for preparing recombinant mycobacterial polypeptides in yeast and their use in diagnosis of mycobacterial related diseases Download PDF

Info

Publication number
WO2008010096A3
WO2008010096A3 PCT/IB2007/002936 IB2007002936W WO2008010096A3 WO 2008010096 A3 WO2008010096 A3 WO 2008010096A3 IB 2007002936 W IB2007002936 W IB 2007002936W WO 2008010096 A3 WO2008010096 A3 WO 2008010096A3
Authority
WO
WIPO (PCT)
Prior art keywords
mycobacterial
diagnosis
related diseases
yeast
polypeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2007/002936
Other languages
French (fr)
Other versions
WO2008010096A2 (en
Inventor
Mohamed Dahmani Fathallah
Mohamed Ridha Barbouche
John L Ho
Chaouki Benabdesselem
Koussay Dellagi
Beya Largueche
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Pasteur
Institut Pasteur de Tunis
Cornell Research Foundation Inc
Original Assignee
Institut Pasteur
Institut Pasteur de Tunis
Cornell Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Pasteur, Institut Pasteur de Tunis, Cornell Research Foundation Inc filed Critical Institut Pasteur
Publication of WO2008010096A2 publication Critical patent/WO2008010096A2/en
Publication of WO2008010096A3 publication Critical patent/WO2008010096A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/41—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a Myc-tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to a method for preparing a mycobacterial polypeptide qualitatively similar to the native mycobacterial protein. The present invention also relates to the mycobacterial polypeptide obtained by the method of invention and its use in method and kit for the diagnosis of mycobacterial related diseases, such as tuberculosis.
PCT/IB2007/002936 2006-07-04 2007-07-04 Method for preparing recombinant mycobacterial polypeptides in yeast and their use in diagnosis of mycobacterial related diseases Ceased WO2008010096A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002551537A CA2551537A1 (en) 2006-07-04 2006-07-04 Method for preparing recombinant mycobacterial polypeptides in yeast and their use in diagnosis of mycobacterial related diseases
CA2551537 2006-07-04

Publications (2)

Publication Number Publication Date
WO2008010096A2 WO2008010096A2 (en) 2008-01-24
WO2008010096A3 true WO2008010096A3 (en) 2008-07-10

Family

ID=38878488

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/002936 Ceased WO2008010096A2 (en) 2006-07-04 2007-07-04 Method for preparing recombinant mycobacterial polypeptides in yeast and their use in diagnosis of mycobacterial related diseases

Country Status (2)

Country Link
CA (1) CA2551537A1 (en)
WO (1) WO2008010096A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106661585B (en) * 2014-04-29 2021-04-09 科纳根公司 Microbial ergothioneine biosynthesis
CN110862969B (en) * 2019-11-28 2021-08-24 扬州大学 Hybridoma cell line secreting anti-CFP-10 antibody, its antibody and its application
AU2023412871A1 (en) * 2022-12-22 2025-07-10 Akagera Medicines, Inc. Lipid nanoparticles for the prevention of tuberculosis or other mycobacterial infections
CN118852457A (en) * 2024-06-25 2024-10-29 中山大学附属第五医院 A Mycobacterium tuberculosis multi-epitope protein and its construction method and application

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6641814B1 (en) * 1997-04-02 2003-11-04 Statens Serum Institut Nucleic acids fragments and polypeptide fragments derived from M. tuberculosis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6641814B1 (en) * 1997-04-02 2003-11-04 Statens Serum Institut Nucleic acids fragments and polypeptide fragments derived from M. tuberculosis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BOOTH R J ET AL: "THE USE OF A UNIVERSAL YEAST EXPRESSION VECTOR TO PRODUCE AN ANTIGENIC PROTEIN OF MYCOBACTERIUM-LEPRAE", IMMUNOLOGY LETTERS, vol. 19, no. 1, 1988, pages 65 - 70, XP002467837, ISSN: 0165-2478 *
CEREGHINO JOAN LIN ET AL: "Heterologous protein expression in the methylotrophic yeast Pichia pastoris", FEMS MICROBIOLOGY REVIEWS, ELSEVIER, AMSTERDAM, NL, vol. 24, no. 1, January 2000 (2000-01-01), pages 45 - 66, XP002195512, ISSN: 0168-6445 *

Also Published As

Publication number Publication date
WO2008010096A2 (en) 2008-01-24
CA2551537A1 (en) 2008-01-04

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