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WO2008010070A3 - Novel oxazolidinone derivatives - Google Patents

Novel oxazolidinone derivatives Download PDF

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Publication number
WO2008010070A3
WO2008010070A3 PCT/IB2007/002019 IB2007002019W WO2008010070A3 WO 2008010070 A3 WO2008010070 A3 WO 2008010070A3 IB 2007002019 W IB2007002019 W IB 2007002019W WO 2008010070 A3 WO2008010070 A3 WO 2008010070A3
Authority
WO
WIPO (PCT)
Prior art keywords
present
pneumoniae
derivatives
oxazolidinone derivatives
novel oxazolidinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2007/002019
Other languages
French (fr)
Other versions
WO2008010070A2 (en
Inventor
Uma Ramachandran
Mrinal Kanti Guha
Ravikumar Tadiparthi
Ganesh Prabhu
Vijayalakshmi Vadarevu
Simi Pushpan
Veenaa Anantharaman
Santhosh Subramanian
Shakti Singh Solanki
Matte Marianna Samuel
Kesavan Koppolu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orchid Research Laboratories Ltd
Original Assignee
Orchid Research Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Research Laboratories Ltd filed Critical Orchid Research Laboratories Ltd
Publication of WO2008010070A2 publication Critical patent/WO2008010070A2/en
Anticipated expiration legal-status Critical
Publication of WO2008010070A3 publication Critical patent/WO2008010070A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to novel compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel Oxazolidinone derivatives of the general formula (I). The novel Oxazolidinone derivatives of the present invention may be useful as antibacterial agents, particularly for intravenous injections and are also useful in the treatment of conditions such as nosocomial pneumoniae, community acquired pneumoniae, Vancomycin resistant enterococci (VRE) caused by Methicillin resistant Staphylococcus Aureus (MRSA) and penicillin resistant Streptococcus Pneumoniae. The compounds of the present invention are effective against a number of human or animal pathogens, clinical isolates, including Vancomycin and Methicillin resistant organisms.
PCT/IB2007/002019 2006-07-19 2007-07-18 Novel oxazolidinone derivatives Ceased WO2008010070A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1253CH2006 2006-07-19
IN1253/CHE/2006 2006-07-19

Publications (2)

Publication Number Publication Date
WO2008010070A2 WO2008010070A2 (en) 2008-01-24
WO2008010070A3 true WO2008010070A3 (en) 2010-02-11

Family

ID=38957145

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/002019 Ceased WO2008010070A2 (en) 2006-07-19 2007-07-18 Novel oxazolidinone derivatives

Country Status (1)

Country Link
WO (1) WO2008010070A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023384A1 (en) * 1992-05-08 1993-11-25 The Upjohn Company Oxazolidinones containing a substituted diazine moiety and their use as antimicrobials
JPH11322729A (en) * 1998-03-09 1999-11-24 Hokuriku Seiyaku Co Ltd Dithiocarbamic acid derivative
EP1130016A1 (en) * 1998-11-11 2001-09-05 Hokuriku Seiyaku Co., Ltd. Thiocarbamic acid derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023384A1 (en) * 1992-05-08 1993-11-25 The Upjohn Company Oxazolidinones containing a substituted diazine moiety and their use as antimicrobials
JPH11322729A (en) * 1998-03-09 1999-11-24 Hokuriku Seiyaku Co Ltd Dithiocarbamic acid derivative
EP1130016A1 (en) * 1998-11-11 2001-09-05 Hokuriku Seiyaku Co., Ltd. Thiocarbamic acid derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS [online] 20 March 2009 (2009-03-20), Database accession no. 2007:249549 *
DATABASE CAPLUS [online] 20 March 2009 (2009-03-20), Database accession no. 2007:413000 *

Also Published As

Publication number Publication date
WO2008010070A2 (en) 2008-01-24

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