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WO2008008907A3 - Antiviral agents - Google Patents

Antiviral agents Download PDF

Info

Publication number
WO2008008907A3
WO2008008907A3 PCT/US2007/073386 US2007073386W WO2008008907A3 WO 2008008907 A3 WO2008008907 A3 WO 2008008907A3 US 2007073386 W US2007073386 W US 2007073386W WO 2008008907 A3 WO2008008907 A3 WO 2008008907A3
Authority
WO
WIPO (PCT)
Prior art keywords
antiviral agents
compositions
compounds
formula
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/073386
Other languages
French (fr)
Other versions
WO2008008907A2 (en
Inventor
Franz Ulrich Schmitz
Christopher Don Roberts
Ronald Conrad Griffith
Janos Botyanszki
Son Minh Pham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genelabs Technologies Inc
Original Assignee
Genelabs Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genelabs Technologies Inc filed Critical Genelabs Technologies Inc
Publication of WO2008008907A2 publication Critical patent/WO2008008907A2/en
Publication of WO2008008907A3 publication Critical patent/WO2008008907A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Disclosed are compounds and compositions of Formula (I) and their uses for treating Flaviviridae family virus infections.
PCT/US2007/073386 2006-07-14 2007-07-12 Antiviral agents Ceased WO2008008907A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83104006P 2006-07-14 2006-07-14
US60/831,040 2006-07-14

Publications (2)

Publication Number Publication Date
WO2008008907A2 WO2008008907A2 (en) 2008-01-17
WO2008008907A3 true WO2008008907A3 (en) 2008-03-20

Family

ID=38742551

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2007/073391 Ceased WO2008008912A1 (en) 2006-07-14 2007-07-12 Antiviral agents
PCT/US2007/073386 Ceased WO2008008907A2 (en) 2006-07-14 2007-07-12 Antiviral agents

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2007/073391 Ceased WO2008008912A1 (en) 2006-07-14 2007-07-12 Antiviral agents

Country Status (13)

Country Link
EP (1) EP2044083A1 (en)
JP (1) JP2009543807A (en)
KR (1) KR20090033881A (en)
CN (1) CN101490058A (en)
AR (1) AR062258A1 (en)
AU (1) AU2007272441A1 (en)
BR (1) BRPI0714346A2 (en)
CA (1) CA2657651A1 (en)
MX (1) MX2009000513A (en)
PE (1) PE20080427A1 (en)
RU (1) RU2009105196A (en)
TW (1) TW200813070A (en)
WO (2) WO2008008912A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070049593A1 (en) 2004-02-24 2007-03-01 Japan Tobacco Inc. Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
US7659263B2 (en) 2004-11-12 2010-02-09 Japan Tobacco Inc. Thienopyrrole compound and use thereof as HCV polymerase inhibitor
EP2142215B1 (en) 2007-05-04 2012-03-07 Vertex Pharmceuticals Incorporated Combination therapy for the treatment of hcv infection
JP2013514982A (en) 2009-12-18 2013-05-02 イデニク プハルマセウティカルス，インコーポレイテッド 5,5-condensed arylene or heteroarylene hepatitis C virus inhibitor
WO2012087833A1 (en) * 2010-12-22 2012-06-28 Abbott Laboratories Hepatitis c inhibitors and uses thereof
US20120252721A1 (en) * 2011-03-31 2012-10-04 Idenix Pharmaceuticals, Inc. Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor
FR3008975A1 (en) * 2013-07-23 2015-01-30 Servier Lab NOVEL PYRROLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
RU2546006C1 (en) 2014-03-07 2015-04-10 Римма Ильинична Ашкинази Antiviral agent
WO2016118043A1 (en) 2015-01-20 2016-07-28 Виктор Вениаминович ТЕЦ Hemostatic agent
US10167293B2 (en) * 2016-05-26 2019-01-01 Bayer Pharma Aktiengesellschaft [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones
JP7475144B2 (en) 2017-05-24 2024-04-26 ヴェニアミノヴィッチ テッツ ヴィクトル Fractionated antimicrobial compositions and uses thereof
WO2022221642A1 (en) 2021-04-16 2022-10-20 Gilead Sciences, Inc. Thienopyrrole compounds
TW202440078A (en) 2021-09-10 2024-10-16 美商基利科學股份有限公司 Thienopyrrole compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002100851A2 (en) * 2001-06-11 2002-12-19 Shire Biochem Inc. Thiophene derivatives as antiviral agents for flavivirus infection
WO2004108687A2 (en) * 2003-06-04 2004-12-16 Genelabs Technologies, Inc. Nitrogen-containing heteroaryl derivatives for the treatment of hcv-infection

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002100851A2 (en) * 2001-06-11 2002-12-19 Shire Biochem Inc. Thiophene derivatives as antiviral agents for flavivirus infection
WO2004108687A2 (en) * 2003-06-04 2004-12-16 Genelabs Technologies, Inc. Nitrogen-containing heteroaryl derivatives for the treatment of hcv-infection

Also Published As

Publication number Publication date
CN101490058A (en) 2009-07-22
AU2007272441A1 (en) 2008-01-17
RU2009105196A (en) 2010-08-27
BRPI0714346A2 (en) 2013-03-19
JP2009543807A (en) 2009-12-10
WO2008008912A1 (en) 2008-01-17
WO2008008907A2 (en) 2008-01-17
PE20080427A1 (en) 2008-06-11
EP2044083A1 (en) 2009-04-08
AR062258A1 (en) 2008-10-29
MX2009000513A (en) 2009-03-09
KR20090033881A (en) 2009-04-06
AU2007272441A2 (en) 2009-03-19
TW200813070A (en) 2008-03-16
CA2657651A1 (en) 2008-01-17

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