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WO2008007153A3 - Antiviral compounds - Google Patents

Antiviral compounds Download PDF

Info

Publication number
WO2008007153A3
WO2008007153A3 PCT/GB2007/050410 GB2007050410W WO2008007153A3 WO 2008007153 A3 WO2008007153 A3 WO 2008007153A3 GB 2007050410 W GB2007050410 W GB 2007050410W WO 2008007153 A3 WO2008007153 A3 WO 2008007153A3
Authority
WO
WIPO (PCT)
Prior art keywords
antiviral compounds
group
formula
pharmaceutically acceptable
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2007/050410
Other languages
French (fr)
Other versions
WO2008007153A2 (en
Inventor
Graham Michael Wynne
Richard Storer
Richard James Tennant-Eyles
Well Renate Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
iQur Ltd
Original Assignee
iQur Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by iQur Ltd filed Critical iQur Ltd
Publication of WO2008007153A2 publication Critical patent/WO2008007153A2/en
Publication of WO2008007153A3 publication Critical patent/WO2008007153A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

There are described compounds of formula (I): wherein, at least one of R1, R2 and R3 represents a group S-L- and the remainder represent H; S represents a binding group; L represents a linker chain; X represents O or NH; and pharmaceutically acceptable derivatives thereof, methods for their preparation, compositions containing them and their use as antiviral agents.
PCT/GB2007/050410 2006-07-14 2007-07-16 Antiviral compounds Ceased WO2008007153A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0614034.7 2006-07-14
GBGB0614034.7A GB0614034D0 (en) 2006-07-14 2006-07-14 Antiviral compounds

Publications (2)

Publication Number Publication Date
WO2008007153A2 WO2008007153A2 (en) 2008-01-17
WO2008007153A3 true WO2008007153A3 (en) 2008-05-08

Family

ID=36955679

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/050410 Ceased WO2008007153A2 (en) 2006-07-14 2007-07-16 Antiviral compounds

Country Status (2)

Country Link
GB (1) GB0614034D0 (en)
WO (1) WO2008007153A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2675934C (en) * 2007-01-23 2015-09-15 Therapicon Srl Antiviral compounds
US20120295866A1 (en) * 2011-04-13 2012-11-22 NuTek Pharma Ltd. Synthesis And Use Of Glycoside Pro-Drug Analogs
US9828406B2 (en) * 2011-05-27 2017-11-28 Kinki University Antitumor agent
CN107513055B (en) * 2017-08-11 2018-06-22 广东昊邦医药健康有限责任公司 A kind of Ribavirin derivative compound and its pharmaceutical composition
SG11202004449TA (en) 2017-11-13 2020-06-29 Extremochem Lda Neutral glycosylated amides and dianionic glucuronidated acids as stabilizers for biological molecules
WO2019140304A1 (en) 2018-01-11 2019-07-18 Virgina Tech Intellectual Properties Inc. Amphiphilic polysacchardides,polysaccharide-based hydrogels, and methods of manufacture
CN111320662B (en) * 2020-02-17 2022-11-25 南京医科大学 N-benzyl substituted diamidinonazine derivative and pharmaceutical application thereof
CN119431480B (en) * 2024-10-25 2025-11-25 武汉大学 A glucosylated ribavirin compound, its preparation method and application

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023494A1 (en) * 1995-12-21 1997-07-03 Icn Pharmaceuticals Carbohydrate conjugated bio-active compounds
WO2006050421A1 (en) * 2004-11-02 2006-05-11 New River Pharmaceuticals Inc. Prodrugs of ribavirin with improved hepatic delivery

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023494A1 (en) * 1995-12-21 1997-07-03 Icn Pharmaceuticals Carbohydrate conjugated bio-active compounds
WO2006050421A1 (en) * 2004-11-02 2006-05-11 New River Pharmaceuticals Inc. Prodrugs of ribavirin with improved hepatic delivery

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HANNA, NAEEM B. ET AL: "Synthesis of 5'-O-.beta.-D-glucopyranosyl and 5'-O-.beta.-D- galactopyranosyl derivatives of ribavirin", CARBOHYDRATE RESEARCH , 165(2), 267-74 CODEN: CRBRAT; ISSN: 0008-6215, 1987, XP009019399 *

Also Published As

Publication number Publication date
GB0614034D0 (en) 2006-08-23
WO2008007153A2 (en) 2008-01-17

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