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WO2008006363A3 - Behandlung von t-zell-malignomen mit bcl11b-inhibitoren - Google Patents

Behandlung von t-zell-malignomen mit bcl11b-inhibitoren Download PDF

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Publication number
WO2008006363A3
WO2008006363A3 PCT/DE2007/001266 DE2007001266W WO2008006363A3 WO 2008006363 A3 WO2008006363 A3 WO 2008006363A3 DE 2007001266 W DE2007001266 W DE 2007001266W WO 2008006363 A3 WO2008006363 A3 WO 2008006363A3
Authority
WO
WIPO (PCT)
Prior art keywords
bcl11b
inhibitors
treatment
cell carcinomas
carcinomas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2007/001266
Other languages
English (en)
French (fr)
Other versions
WO2008006363A2 (de
Inventor
Christian Andreas Schmidt
Piotr Grabarczyk
Grzegorz Przybylski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitaet Greifswald
Original Assignee
Ernst Moritz Arndt Universitaet Greifswald
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ernst Moritz Arndt Universitaet Greifswald filed Critical Ernst Moritz Arndt Universitaet Greifswald
Publication of WO2008006363A2 publication Critical patent/WO2008006363A2/de
Publication of WO2008006363A3 publication Critical patent/WO2008006363A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Die vorliegende Erfindung betrifft die Verwendung von BCL11b-Inhibitoren zur Behandlung von T-Zell-Malignomen.
PCT/DE2007/001266 2006-07-13 2007-07-13 Behandlung von t-zell-malignomen mit bcl11b-inhibitoren Ceased WO2008006363A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006032424.2 2006-07-13
DE102006032424A DE102006032424A1 (de) 2006-07-13 2006-07-13 Behandlung von T-Zell-Malignomen

Publications (2)

Publication Number Publication Date
WO2008006363A2 WO2008006363A2 (de) 2008-01-17
WO2008006363A3 true WO2008006363A3 (de) 2008-06-26

Family

ID=38825234

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2007/001266 Ceased WO2008006363A2 (de) 2006-07-13 2007-07-13 Behandlung von t-zell-malignomen mit bcl11b-inhibitoren

Country Status (2)

Country Link
DE (1) DE102006032424A1 (de)
WO (1) WO2008006363A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071815B2 (en) 2008-07-17 2011-12-06 Arup Kumar Indra CTIP2 expression in squamous cell carcinoma
CN103409466B (zh) * 2013-05-27 2015-01-21 中国科学院广州生物医药与健康研究院 一种使bcl11b蛋白降解的方法
WO2017192959A2 (en) * 2016-05-05 2017-11-09 The Research Foundation For The State University Of New York Therapeutically modulating apob and apoai
WO2024227030A1 (en) * 2023-04-28 2024-10-31 H. Lee Moffitt Cancer Center And Research Institute, Inc. Bcl11b sustains multipotency and restricts effector programs of intestinal resident memory cd8+ t cells

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070237770A1 (en) * 2001-11-30 2007-10-11 Albert Lai Novel compositions and methods in cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003008583A2 (en) * 2001-03-02 2003-01-30 Sagres Discovery Novel compositions and methods for cancer
US7250496B2 (en) * 2002-11-14 2007-07-31 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory genes and uses thereof
WO2005040379A2 (en) * 2003-10-23 2005-05-06 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF RAS GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070237770A1 (en) * 2001-11-30 2007-10-11 Albert Lai Novel compositions and methods in cancer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CISMASIU V B ET AL: "BCL11B functionally associates with the NuRD complex in T lymphocates to repress targeted promotor", ONCOGENE, vol. 24, 2005, pages 6753 - 6764, XP002475287 *
GRABARCZYK P. ET AL: "Inhibition of BCL11B expression leads to apoptosis of malignant but not normal mature T cells", ONCOGENE, vol. 26, 2007, pages 3797 - 3810, XP002475284 *
MACLEOD RAF ET AL: "BCL11B rearragemants probably target T-cell neoplasia rather than acute myelocytic leukemia", CANCER GENETICS AND CYTOGENETICS, vol. 153, 2004, pages 88 - 89, XP002475285 *
OSHIRO A. ET AL: "Identification of subtype-specific genomic alterations in aggrsessive adult T-cell leukemia/lymphoma", BLOOD, vol. 107, no. 11, June 2006 (2006-06-01), pages 4500 - 4507, XP002475286 *

Also Published As

Publication number Publication date
DE102006032424A1 (de) 2008-01-17
WO2008006363A2 (de) 2008-01-17

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