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WO2008006007A3 - Defective cystic fibrosis transduction regulator (cftr) causes increased sphingolipid synthesis - Google Patents

Defective cystic fibrosis transduction regulator (cftr) causes increased sphingolipid synthesis Download PDF

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Publication number
WO2008006007A3
WO2008006007A3 PCT/US2007/072801 US2007072801W WO2008006007A3 WO 2008006007 A3 WO2008006007 A3 WO 2008006007A3 US 2007072801 W US2007072801 W US 2007072801W WO 2008006007 A3 WO2008006007 A3 WO 2008006007A3
Authority
WO
WIPO (PCT)
Prior art keywords
cystic fibrosis
cftr
causes increased
sphingolipid synthesis
transduction regulator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/072801
Other languages
French (fr)
Other versions
WO2008006007A2 (en
Inventor
Tilla Worgall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Columbia University in the City of New York
Original Assignee
Columbia University in the City of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Columbia University in the City of New York filed Critical Columbia University in the City of New York
Publication of WO2008006007A2 publication Critical patent/WO2008006007A2/en
Publication of WO2008006007A3 publication Critical patent/WO2008006007A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to methods and compositions for treating cystic fibrosis and P. aeruginosa infections by administering a therapeutic amount of one or more agents that inhibit de novo sphingolipid synthesis or recycling pathways.
PCT/US2007/072801 2006-07-03 2007-07-03 Defective cystic fibrosis transduction regulator (cftr) causes increased sphingolipid synthesis Ceased WO2008006007A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81835106P 2006-07-03 2006-07-03
US60/818,351 2006-07-03

Publications (2)

Publication Number Publication Date
WO2008006007A2 WO2008006007A2 (en) 2008-01-10
WO2008006007A3 true WO2008006007A3 (en) 2008-10-30

Family

ID=38895458

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/072801 Ceased WO2008006007A2 (en) 2006-07-03 2007-07-03 Defective cystic fibrosis transduction regulator (cftr) causes increased sphingolipid synthesis

Country Status (1)

Country Link
WO (1) WO2008006007A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0712494D0 (en) 2007-06-27 2007-08-08 Isis Innovation Substrate reduction therapy
US20100080807A1 (en) * 2008-09-26 2010-04-01 National Taiwan University Methods and Compositions for Treating Viral Hemorrhagic Fever
ITFE20080032A1 (en) * 2008-10-23 2010-04-24 Azienda Ospedaliera Istituti Ospit Alieri Di Vero ANTI-INFLAMMATORY EFFECT OF MIGLUSTAT CELLULE OF BRONCHIAL EPITHELIUM
WO2014061016A1 (en) * 2012-10-15 2014-04-24 Yeda Research And Development Co. Ltd. Use of sphingoid long chain bases and their analogs in treating and preventing bacterial infections
US10406127B2 (en) 2014-07-25 2019-09-10 Laurent Pharmaceuticals Solid oral formulation of fenretinide
EP3171860B1 (en) * 2014-07-25 2024-12-11 Laurent Pharmaceuticals Solid oral formulation of fenretinide
WO2020011744A2 (en) * 2018-07-11 2020-01-16 Roche Innovation Center Copenhagen A/S Antisense oligonucleotides targeting cers5
WO2020011745A2 (en) * 2018-07-11 2020-01-16 Roche Innovation Center Copenhagen A/S Antisense oligonucleotides targeting cers6
IL260690A (en) 2018-07-19 2018-12-31 Yeda Res & Dev Sphingosine analogs and use thereof against bacterial lung infections
US12391947B2 (en) 2018-11-29 2025-08-19 University Of Massachusetts Modulation of SPTLC1 via recombinant adeno-associated vectors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070197656A1 (en) * 2004-03-02 2007-08-23 Stan Kubow Compositions and methods for preventing or treating an inflammatory response

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070197656A1 (en) * 2004-03-02 2007-08-23 Stan Kubow Compositions and methods for preventing or treating an inflammatory response

Also Published As

Publication number Publication date
WO2008006007A2 (en) 2008-01-10

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