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WO2008002544A3 - Unit dosage forms of temozolomide - Google Patents

Unit dosage forms of temozolomide Download PDF

Info

Publication number
WO2008002544A3
WO2008002544A3 PCT/US2007/014761 US2007014761W WO2008002544A3 WO 2008002544 A3 WO2008002544 A3 WO 2008002544A3 US 2007014761 W US2007014761 W US 2007014761W WO 2008002544 A3 WO2008002544 A3 WO 2008002544A3
Authority
WO
WIPO (PCT)
Prior art keywords
dosage forms
unit dosage
temozolomide
relates
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/014761
Other languages
French (fr)
Other versions
WO2008002544A2 (en
Inventor
Jacqueline Rose Bersch
Mark Manzo
Sumant Ramachandra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to BRPI0702847-4A priority Critical patent/BRPI0702847A/en
Priority to EP07796436A priority patent/EP1901740A2/en
Priority to CA002610439A priority patent/CA2610439A1/en
Priority to JP2008523051A priority patent/JP2008534692A/en
Priority to NO20074913A priority patent/NO20074913L/en
Publication of WO2008002544A2 publication Critical patent/WO2008002544A2/en
Publication of WO2008002544A3 publication Critical patent/WO2008002544A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4883—Capsule finishing, e.g. dyeing, aromatising, polishing

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

This invention relates to unit dosage forms of temozolomide. These unit dosage forms are particularly well-suited for decreasing the pill burden and increasing patient compliance. The invention also relates to methods of treating proliferative disorders in a patient with these unit dosage forms. The invention additionally relates to kits comprising these unit dosage forms.
PCT/US2007/014761 2006-06-26 2007-06-25 Unit dosage forms of temozolomide Ceased WO2008002544A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
BRPI0702847-4A BRPI0702847A (en) 2006-06-26 2007-06-25 temozolomide unit dosage forms
EP07796436A EP1901740A2 (en) 2006-06-26 2007-06-25 Unit dosage forms of temozolomide
CA002610439A CA2610439A1 (en) 2006-06-26 2007-06-25 Unit dosage forms of temozolomide
JP2008523051A JP2008534692A (en) 2006-06-26 2007-06-25 Temozolomide unit dosage form
NO20074913A NO20074913L (en) 2006-06-26 2007-09-27 Unit dosage forms of temozolomide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81662306P 2006-06-26 2006-06-26
US60/816,623 2006-06-26

Publications (2)

Publication Number Publication Date
WO2008002544A2 WO2008002544A2 (en) 2008-01-03
WO2008002544A3 true WO2008002544A3 (en) 2008-02-07

Family

ID=38704663

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/014761 Ceased WO2008002544A2 (en) 2006-06-26 2007-06-25 Unit dosage forms of temozolomide

Country Status (13)

Country Link
EP (1) EP1901740A2 (en)
JP (1) JP2008534692A (en)
KR (2) KR20080015777A (en)
CN (1) CN101309686A (en)
AR (1) AR061618A1 (en)
AU (1) AU2007221979A1 (en)
BR (1) BRPI0702847A (en)
CA (1) CA2610439A1 (en)
CL (1) CL2007001864A1 (en)
NO (1) NO20074913L (en)
TW (1) TWI326598B (en)
WO (1) WO2008002544A2 (en)
ZA (1) ZA200708280B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102526038B (en) * 2011-01-12 2013-09-11 北京人福军威医药技术开发有限公司 Temozolomide brain-targeting pharmaceutical composition and application thereof
WO2017165266A1 (en) * 2016-03-21 2017-09-28 Duke University Sequential anti-cancer treatment
US11147810B2 (en) 2017-03-13 2021-10-19 Ftf Pharma Private Limited Pharmaceutical composition of oral suspension of anti-neoplastic alkylating agents

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000057867A2 (en) * 1999-03-30 2000-10-05 Schering Corporation Improved cancer treatment with temozolomide
WO2006052976A2 (en) * 2004-11-09 2006-05-18 Schering Corporation Improved dosing regimen of temozolomide for treating cancer based on the patient’s mgmt level

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000057867A2 (en) * 1999-03-30 2000-10-05 Schering Corporation Improved cancer treatment with temozolomide
WO2006052976A2 (en) * 2004-11-09 2006-05-18 Schering Corporation Improved dosing regimen of temozolomide for treating cancer based on the patient’s mgmt level

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "European Public Assessment Report TEMODAL, summary for the public", May 2007 (2007-05-01), XP002460102, Retrieved from the Internet <URL:HTTP://WWW.EMEA.EUROPA.EU/HUMANDOCS/PDFS/EPAR/TEMODAL/274198EN1.PDF> [retrieved on 20071127] *
ANONYMOUS: "Temodar (temozolomide) capsules - Product information-", November 2006 (2006-11-01), XP002460101, Retrieved from the Internet <URL:HTTP://WWW.SPFILES.COM/PITEMODAR.PDF> [retrieved on 20071127] *

Also Published As

Publication number Publication date
AU2007221979A9 (en) 2008-01-10
CA2610439A1 (en) 2007-12-26
NO20074913L (en) 2009-03-26
TWI326598B (en) 2010-07-01
CL2007001864A1 (en) 2008-02-08
ZA200708280B (en) 2009-03-25
JP2008534692A (en) 2008-08-28
KR20080015777A (en) 2008-02-20
AR061618A1 (en) 2008-09-10
CN101309686A (en) 2008-11-19
AU2007221979A1 (en) 2008-01-10
BRPI0702847A (en) 2008-04-01
EP1901740A2 (en) 2008-03-26
TW200808803A (en) 2008-02-16
WO2008002544A2 (en) 2008-01-03
KR20100055543A (en) 2010-05-26

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