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WO2008001379A3 - Activated myeloid cells for promoting tissue repair and detecting damaged tissue - Google Patents

Activated myeloid cells for promoting tissue repair and detecting damaged tissue Download PDF

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Publication number
WO2008001379A3
WO2008001379A3 PCT/IL2007/000797 IL2007000797W WO2008001379A3 WO 2008001379 A3 WO2008001379 A3 WO 2008001379A3 IL 2007000797 W IL2007000797 W IL 2007000797W WO 2008001379 A3 WO2008001379 A3 WO 2008001379A3
Authority
WO
WIPO (PCT)
Prior art keywords
myeloid cells
tissue
promoting
detecting damaged
cells
Prior art date
Application number
PCT/IL2007/000797
Other languages
French (fr)
Other versions
WO2008001379A2 (en
Inventor
Michal Eisenbach-Schwartz
Oleg Butovsky
Gilad Kunis
Shay Bukshpan
Original Assignee
Yeda Res & Dev
Michal Eisenbach-Schwartz
Oleg Butovsky
Gilad Kunis
Shay Bukshpan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev, Michal Eisenbach-Schwartz, Oleg Butovsky, Gilad Kunis, Shay Bukshpan filed Critical Yeda Res & Dev
Priority to EP07766828A priority Critical patent/EP2043666A2/en
Publication of WO2008001379A2 publication Critical patent/WO2008001379A2/en
Priority to IL196172A priority patent/IL196172A0/en
Publication of WO2008001379A3 publication Critical patent/WO2008001379A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/105—Insulin-like growth factors [IGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/24—Interferons [IFN]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurosurgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A cellular preparation comprising CD11c+ bone marrow-derived myeloid cells is provided for promoting repair of damaged body tissue. When labeled with a suitable imaging agent, the cells can be used to detect and localize a damaged body tissue. The cells are obtained by activation of bone marrow-derived myeloid cells with a cytokine, preferably IL-4.
PCT/IL2007/000797 2006-06-28 2007-06-28 Activated myeloid cells for promoting tissue repair and detecting damaged tissue WO2008001379A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07766828A EP2043666A2 (en) 2006-06-28 2007-06-28 Activated myeloid cells for promoting tissue repair and detecting damaged tissue
IL196172A IL196172A0 (en) 2006-06-28 2008-12-25 Activated myeloid cells for promoting tissue repair and detecting damaged tissue

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80605506P 2006-06-28 2006-06-28
US60/806,055 2006-06-28
US80726406P 2006-07-13 2006-07-13
US60/807,264 2006-07-13

Publications (2)

Publication Number Publication Date
WO2008001379A2 WO2008001379A2 (en) 2008-01-03
WO2008001379A3 true WO2008001379A3 (en) 2009-04-30

Family

ID=38846103

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2007/000797 WO2008001379A2 (en) 2006-06-28 2007-06-28 Activated myeloid cells for promoting tissue repair and detecting damaged tissue

Country Status (2)

Country Link
EP (1) EP2043666A2 (en)
WO (1) WO2008001379A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107988157A (en) * 2017-11-28 2018-05-04 航天中心医院 A kind of Dendritic Cells Induced culture medium and its application

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5243456B2 (en) 2007-03-02 2013-07-24 スミス アンド ネフュー ピーエルシー Filter cleaning apparatus and method with ultrasonic, backwash and filter motion during biological sample filtration

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006056998A2 (en) * 2004-11-29 2006-06-01 Yeda Research And Development Co. Ltd. Methods of cell therapy, neurogenesis and oligodendrogenesis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006056998A2 (en) * 2004-11-29 2006-06-01 Yeda Research And Development Co. Ltd. Methods of cell therapy, neurogenesis and oligodendrogenesis

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BUTOVSKY ET AL.: "Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and reders therm cytotoxic whereas IFN-gamma and IL-4 render them protective.", MOL. CELL. NEUROSC., vol. 29, March 2005 (2005-03-01), pages 381 - 393, XP004930779 *
CHEN ET AL.: "Glatiramer acetate-reactive T cells produce brain derived neurotrophic factor.", J NEUROL SC., vol. 215, 2003, pages 37 - 44, XP008076627 *
FUKUDA ET AL.: "Stem cells as a source of regenerative cardiomyocytes.", CIRC. RES., vol. 98, April 2006 (2006-04-01), pages 1002 - 1013, XP008107994 *
SILANI ET AL.: "Stem-cell therapy for amyotrophic lateral sclerosis.", LANCET, vol. 364, 2004, pages 200 - 202, XP005070196 *
SIMARD ET AL.: "Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia.", THE FASEB J., vol. 18, April 2004 (2004-04-01), pages 998 - 1000, XP008107995 *
SIMARD ET AL.: "Bone marrow-derived microglia play a critical role in restricting senile plaque formation in alzheimer's disease.", NEURON., vol. 49, February 2006 (2006-02-01), pages 489 - 502, XP002996785 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107988157A (en) * 2017-11-28 2018-05-04 航天中心医院 A kind of Dendritic Cells Induced culture medium and its application
CN107988157B (en) * 2017-11-28 2020-12-15 航天中心医院 A kind of dendritic cell induction medium and its application

Also Published As

Publication number Publication date
EP2043666A2 (en) 2009-04-08
WO2008001379A2 (en) 2008-01-03

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