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WO2008099418A3 - An improved process for preparing bupropion hydrochloride - Google Patents

An improved process for preparing bupropion hydrochloride Download PDF

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Publication number
WO2008099418A3
WO2008099418A3 PCT/IN2008/000053 IN2008000053W WO2008099418A3 WO 2008099418 A3 WO2008099418 A3 WO 2008099418A3 IN 2008000053 W IN2008000053 W IN 2008000053W WO 2008099418 A3 WO2008099418 A3 WO 2008099418A3
Authority
WO
WIPO (PCT)
Prior art keywords
bupropion hydrochloride
improved process
preparing
preparing bupropion
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2008/000053
Other languages
French (fr)
Other versions
WO2008099418A2 (en
Inventor
Pandurang Balwant Deshpande
Rashid Abdul Rehman Khan
Dhiraj Mohansinh Rathod
Lalitkumar Keshavlal Katariya
Himanshu Manojkumar Mehta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alembic Ltd
Original Assignee
Alembic Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alembic Ltd filed Critical Alembic Ltd
Publication of WO2008099418A2 publication Critical patent/WO2008099418A2/en
Publication of WO2008099418A3 publication Critical patent/WO2008099418A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to an improved process for preparing Bupropion Hydrochloride of formula (I). The present invention also provides a process for purification of Bupropion hydrochloride.
PCT/IN2008/000053 2007-02-12 2008-01-29 An improved process for preparing bupropion hydrochloride Ceased WO2008099418A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN267/MUM/2007 2007-02-12
IN267MU2007 2007-02-12

Publications (2)

Publication Number Publication Date
WO2008099418A2 WO2008099418A2 (en) 2008-08-21
WO2008099418A3 true WO2008099418A3 (en) 2008-11-13

Family

ID=39410189

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000053 Ceased WO2008099418A2 (en) 2007-02-12 2008-01-29 An improved process for preparing bupropion hydrochloride

Country Status (1)

Country Link
WO (1) WO2008099418A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103113241A (en) * 2011-11-16 2013-05-22 锦西化工研究院 Synthetic method of diethylaminoethoxyethanol
CN104356013A (en) * 2014-11-18 2015-02-18 浙江海翔药业股份有限公司 Preparation method of alpha-(N-methyl-N-benzylamino)-3-hydroxyacetophenone hydrochloride
CN114874084B (en) * 2022-01-28 2023-12-19 浙江普洛家园药业有限公司 Preparation method of bupropion hydrochloride impurity F

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004024674A1 (en) * 2002-09-10 2004-03-25 Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. Process for the preparation of bupropion hydrochloride
WO2004089873A1 (en) * 2003-04-11 2004-10-21 Erregierre S.P.A. Process for crystallising bupropion hydrochloride

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004024674A1 (en) * 2002-09-10 2004-03-25 Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. Process for the preparation of bupropion hydrochloride
WO2004089873A1 (en) * 2003-04-11 2004-10-21 Erregierre S.P.A. Process for crystallising bupropion hydrochloride

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DANIEL M. PERRINE ET AL: "A Short, One-Pot Synthesis of Bupropion", J. CHEM. ED., vol. 77, no. 11, 2000, pages 1479 - 1480, XP009100813 *
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002481860, retrieved from XFIRE Database accession no. 1072952 *
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XIA, MIN ET AL: "Study on synthesis of the amfebutamone hydrochloride", XP002481859, retrieved from STN Database accession no. 2003:643664 *
HAMAD ET AL: "Synthesis and hydrolytic behavior of two novel tripartate codrugs of naltrexone and 6beta-naltrexol with hydroxybupropion as potential alcohol abuse and smoking cessation agents", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 14, no. 20, 15 October 2006 (2006-10-15), pages 7051 - 7061, XP005633152, ISSN: 0968-0896 *
J. ORG. CHEM., vol. 68, no. 4, 2003, pages 1594 - 1596 *
XIA, MIN; XU, BAO-FENG, SHANDONG HUAGONG, vol. 32, no. 3, 2003, pages 3 - 5, XP009100846 *

Also Published As

Publication number Publication date
WO2008099418A2 (en) 2008-08-21

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