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WO2008099492A1 - ピリミジンヌクレオシド誘導体及びその塩 - Google Patents

ピリミジンヌクレオシド誘導体及びその塩 Download PDF

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Publication number
WO2008099492A1
WO2008099492A1 PCT/JP2007/052758 JP2007052758W WO2008099492A1 WO 2008099492 A1 WO2008099492 A1 WO 2008099492A1 JP 2007052758 W JP2007052758 W JP 2007052758W WO 2008099492 A1 WO2008099492 A1 WO 2008099492A1
Authority
WO
WIPO (PCT)
Prior art keywords
salt
pyrimidine nucleoside
nucleoside derivative
substituent
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2007/052758
Other languages
English (en)
French (fr)
Inventor
Haruhiko Machida
Masaichi Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arigen Pharmaceuticals Inc
Original Assignee
Arigen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arigen Pharmaceuticals Inc filed Critical Arigen Pharmaceuticals Inc
Priority to US12/438,108 priority Critical patent/US8076302B2/en
Priority to PCT/JP2007/052758 priority patent/WO2008099492A1/ja
Publication of WO2008099492A1 publication Critical patent/WO2008099492A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/09—Pyrimidine radicals with arabinosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

　下記式（１）で表される新規ピリミジンヌクレオシド誘導体及びその塩、並びにこれを有効成分とする医薬組成物は、優れた抗ウイルス特性を有し、抗ウイルス治療剤として有用である。 ［式中Ｒは、置換基として炭素数１～３のアルキル基、又は炭素数１～３のアルコキシ基のうちいずれかを１個有してもよい含窒素複素環、又は一級アミノ基を置換基として１個有する炭素数１～６個のアルキル基を示す］                                                                               
PCT/JP2007/052758 2007-02-15 2007-02-15 ピリミジンヌクレオシド誘導体及びその塩 Ceased WO2008099492A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/438,108 US8076302B2 (en) 2007-02-15 2007-02-15 Pyrimidine nucleoside derivatives and salts thereof
PCT/JP2007/052758 WO2008099492A1 (ja) 2007-02-15 2007-02-15 ピリミジンヌクレオシド誘導体及びその塩

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2007/052758 WO2008099492A1 (ja) 2007-02-15 2007-02-15 ピリミジンヌクレオシド誘導体及びその塩

Publications (1)

Publication Number Publication Date
WO2008099492A1 true WO2008099492A1 (ja) 2008-08-21

Family

ID=39689751

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/052758 Ceased WO2008099492A1 (ja) 2007-02-15 2007-02-15 ピリミジンヌクレオシド誘導体及びその塩

Country Status (2)

Country Link
US (1) US8076302B2 (ja)
WO (1) WO2008099492A1 (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014159731A1 (en) * 2013-03-13 2014-10-02 Nal Pharmaceuticals, Ltd A topical antiviral composition containing a local anesthetic and method of making the same

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5687599A (en) * 1979-12-19 1981-07-16 Yamasa Shoyu Co Ltd E 55 22halogenovinyl arabinofuranosyluracil and its preparation
JPS5843993A (ja) * 1981-09-09 1983-03-14 Yamasa Shoyu Co Ltd １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法
JPH04505920A (ja) * 1989-06-06 1992-10-15 ザ・ウエルカム・ファウンデーション・リミテッド 治療用ヌクレオシド
WO1992019638A1 (en) * 1991-04-24 1992-11-12 Yamasa Shoyu Kabushiki Kaisha 1-β-D-ARABINOFURANOSYL-(E)-5-(2-HALOGENOVINYL)-URACIL DERIVATIVE

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5446031A (en) * 1991-04-24 1995-08-29 Yamasa Shuyu Kabushiki Kaisha 1-β-D-arabinofuranosyl-(E)-5-(2-halogenovinyl)uracil derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5687599A (en) * 1979-12-19 1981-07-16 Yamasa Shoyu Co Ltd E 55 22halogenovinyl arabinofuranosyluracil and its preparation
JPS5843993A (ja) * 1981-09-09 1983-03-14 Yamasa Shoyu Co Ltd １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法
JPH04505920A (ja) * 1989-06-06 1992-10-15 ザ・ウエルカム・ファウンデーション・リミテッド 治療用ヌクレオシド
WO1992019638A1 (en) * 1991-04-24 1992-11-12 Yamasa Shoyu Kabushiki Kaisha 1-β-D-ARABINOFURANOSYL-(E)-5-(2-HALOGENOVINYL)-URACIL DERIVATIVE

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ASHIDA N. ET AL.: "Metabolism of 5'-ether prodrugs of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil in rats", BIOCHEMICAL PHARMACOLOGY, vol. 46, no. 12, 1993, pages 2201 - 2207, XP003023229 *
KANO F. ET AL.: "5'-O-alkyl and acyl prodrugs of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil", ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, vol. 5, no. 2, 1994, pages 74 - 82, XP000909087 *
KULIKOWSKI T. ET AL.: "Pyrimidine arabinofuranosyl nucleosides with 5-substituted long, branched and unsaturated chains: synthesis and antiherpes properties", NUCLEIC ACIDS SYMPOSIUM SERIES, vol. 9, 1981, pages 103 - 106, XP003023234 *
MACHIDA H. ET AL.: "In vitro anti-herpesvirus activities of 5-substituted 2'-deoxy-2'-methylidene pyrimidine nucleosides", ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, vol. 4, no. 1, 1993, pages 11 - 17, XP003023231 *
REEFSCHLAEGER J. ET AL.: "Antiherpes activity of (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil and some other 5-substituted uracil arabinosyl nucleosides in two different cell lines", ANTIVIRAL RESEARCH, vol. 3, no. 3, 1983, pages 175 - 187, XP003023230 *
YU C.-S. ET AL.: "Syntheses of 5-fluoro and (E)-5-(2-fluorovinyl) arabinosyl uridine analogues as potential probes for the HSV-1 thymidine kinase gene", SYNTHESIS, no. 22, 2006, pages 3835 - 3840, XP003023233 *
YU C.-S. ET AL.: "Synthesis of (E)-5-(2-radio-iodovinyl)arabinosyl uridine analog for probing HSV-1 thymidine kinase gene", CHEMISTRY LETTERS, vol. 34, no. 10, 2005, pages 1390 - 1391, XP003023232 *

Also Published As

Publication number Publication date
US20100234405A1 (en) 2010-09-16
US8076302B2 (en) 2011-12-13

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WO2008099492A1 (ja) ピリミジンヌクレオシド誘導体及びその塩

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