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WO2008096730A1 - Anti-inflammatory agent and use thereof - Google Patents

Anti-inflammatory agent and use thereof Download PDF

Info

Publication number
WO2008096730A1
WO2008096730A1 PCT/JP2008/051818 JP2008051818W WO2008096730A1 WO 2008096730 A1 WO2008096730 A1 WO 2008096730A1 JP 2008051818 W JP2008051818 W JP 2008051818W WO 2008096730 A1 WO2008096730 A1 WO 2008096730A1
Authority
WO
WIPO (PCT)
Prior art keywords
inflammatory agent
inflammatory
effect
agent
exhibit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/051818
Other languages
French (fr)
Japanese (ja)
Inventor
Kazuhiro Ishiguro
Hidemi Gotoh
Takahumi Andoh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nagoya University NUC
Original Assignee
Nagoya University NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nagoya University NUC filed Critical Nagoya University NUC
Priority to JP2008557111A priority Critical patent/JPWO2008096730A1/en
Publication of WO2008096730A1 publication Critical patent/WO2008096730A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed are: a novel anti-inflammatory agent; and use of the anti-inflammatory agent. Specifically disclose is an anti-inflammatory agent comprising acetic acid or a salt thereof as the main component. The anti-inflammatory agent can exhibit its anti-inflammatory effect through the specific inhibition of the activation of a transcription factor NFAT. When the anti-inflammatory agent is used in combination with a steroidal anti-inflammatory agent, a higher therapeutic effect can be produced.
PCT/JP2008/051818 2007-02-09 2008-02-05 Anti-inflammatory agent and use thereof Ceased WO2008096730A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008557111A JPWO2008096730A1 (en) 2007-02-09 2008-02-05 Anti-inflammatory agent and its use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-030067 2007-02-09
JP2007030067 2007-02-09

Publications (1)

Publication Number Publication Date
WO2008096730A1 true WO2008096730A1 (en) 2008-08-14

Family

ID=39681639

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/051818 Ceased WO2008096730A1 (en) 2007-02-09 2008-02-05 Anti-inflammatory agent and use thereof

Country Status (2)

Country Link
JP (1) JPWO2008096730A1 (en)
WO (1) WO2008096730A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017198701A1 (en) * 2016-05-17 2017-11-23 Proponent Biotech Gmbh Carboxylic acids for treating/preventing a skin disease
EP3950049A1 (en) * 2015-04-24 2022-02-09 Galvani Bioelectronics Limited Use of an anti-inflammatory agent

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05112422A (en) * 1991-10-21 1993-05-07 Noevir Co Ltd Cosmetic and external preparation for skin
JP2003238399A (en) * 2002-02-20 2003-08-27 Shiono Koryo Kk Hyaluronidase activity inhibitor, perfume composition containing the same, food and drink and cosmetic
WO2005027893A1 (en) * 2003-09-19 2005-03-31 Otsuka Pharmaceutical Co., Ltd. HUMAN β-DEFENSIN SECRETION PROMOTER
JP2006143652A (en) * 2004-11-19 2006-06-08 Meiji Milk Prod Co Ltd Inflammatory bowel disease treatment

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05112422A (en) * 1991-10-21 1993-05-07 Noevir Co Ltd Cosmetic and external preparation for skin
JP2003238399A (en) * 2002-02-20 2003-08-27 Shiono Koryo Kk Hyaluronidase activity inhibitor, perfume composition containing the same, food and drink and cosmetic
WO2005027893A1 (en) * 2003-09-19 2005-03-31 Otsuka Pharmaceutical Co., Ltd. HUMAN β-DEFENSIN SECRETION PROMOTER
JP2006143652A (en) * 2004-11-19 2006-06-08 Meiji Milk Prod Co Ltd Inflammatory bowel disease treatment

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PATZ J. ET AL.: "Treatment of refractory distal ulcerative colitis with short chain fatty acid enemas", AMERICAN JOURNAL OF GASTROENTEROLOGY, vol. 91, no. 4, 1996, pages 731 - 734 *
VERNIA P. ET AL.: "Short-chain fatty acid topical treatment in distal ulcerative colitis", ALIMENTARY PHARMACOLOGY & THERAPEUTICS, vol. 9, no. 3, 1995, pages 309 - 313 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3950049A1 (en) * 2015-04-24 2022-02-09 Galvani Bioelectronics Limited Use of an anti-inflammatory agent
WO2017198701A1 (en) * 2016-05-17 2017-11-23 Proponent Biotech Gmbh Carboxylic acids for treating/preventing a skin disease
CN109152753A (en) * 2016-05-17 2019-01-04 拥护者生物技术有限公司 For treating/preventing dermopathic carboxylic acid

Also Published As

Publication number Publication date
JPWO2008096730A1 (en) 2010-05-20

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