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WO2008096171A2 - Composition laxative naturelle destinée à traiter et prévenir la constipation par une action de nettoyage du côlon - Google Patents

Composition laxative naturelle destinée à traiter et prévenir la constipation par une action de nettoyage du côlon Download PDF

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Publication number
WO2008096171A2
WO2008096171A2 PCT/GB2008/050071 GB2008050071W WO2008096171A2 WO 2008096171 A2 WO2008096171 A2 WO 2008096171A2 GB 2008050071 W GB2008050071 W GB 2008050071W WO 2008096171 A2 WO2008096171 A2 WO 2008096171A2
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WO
WIPO (PCT)
Prior art keywords
dried
natural
laxative composition
composition
senna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2008/050071
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English (en)
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WO2008096171A3 (fr
Inventor
Vitaliy Filipenko
Cornelia Moisa
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Individual
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Individual
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Filing date
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Publication of WO2008096171A2 publication Critical patent/WO2008096171A2/fr
Anticipated expiration legal-status Critical
Publication of WO2008096171A3 publication Critical patent/WO2008096171A3/fr
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives

Definitions

  • Constipation is a condition of the digestive system where a person experiences hard feces that are difficult to eliminate; it may be extremely painful, and in severe cases (fecal impaction) lead to symptoms of bowel obstruction.
  • Constipation is a symptom rather than a disease and is the most common digestive disorder among human beings and the rate of this disorder increases with age. Older adults are five times more likely to have problems with constipation than young people. Today in Great Britain, according to some sources, more than 50% of the population is suffering with constipation, in Germany the number is 30%, and in France about 20%. In Eastern European countries on average more than 50% of the population suffers from constipation!
  • Constipation is caused by a number of factors including irritable bowel syndrome, lack of dietary fiber, inadequate water intake, eating disorders, some medications, psychiatric disorders, haemorrhoids, hormonal disturbances, diseases of the colon such as bowel cancer and other factors.
  • Laxatives are the most commonly used medicines to help relieve constipation.
  • laxatives available on the market: bulk-forming laxatives such as bran (Trifyba) and ispaghula husk (Fybogel); osmotic laxatives such as lactulose; and stimulant laxatives like senna (e.g. Senokot). They all work in different ways to help relieve or prevent constipation.
  • each of these laxatives has certain contraindications as it may cause severe side-effects and worsen the constipation condition even further posing risk to a person's health.
  • Osmotic laxatives work by drawing more water into the bowel. Over-using this type of laxatives can be extremely dangerous as it can damage the bowel and lead to an imbalance of essential chemicals in the body.
  • Stimulant laxatives are usually comprised of herbal ingredients such as senna, aloe, cascara or other laxative plants which work by speeding up bowel movement. Senna is most widely used laxative herb and has become a primary ingredient in the wide range of laxative medicines available on the market.
  • Major problem with senna laxative is that if used in high doses or for prolonged periods of time, it can reduce the level of colonic potassium ions (K+) in the colonic mucus which results in electrolyte disturbances and fluid imbalances. This is one of the primary factors leading to 'lazy-bowel syndrome' - a dependency on laxatives to have any bowel movements as the muscles of the stomach and intestines gradually lose the ability to contract without being stimulated by the laxative. Considerable potassium depletion can be very dangerous for those with heart rhythm irregularities.
  • Bran is the hard outer layer of cereal grains. Although raw bran is very rich is dietary fiber and contains some vitamins, it is quite unpalatable. It doesn't provide the other nutrients found in fiber-rich foods such as wholemeal bread, wholegrain cereals, dried fruits, etc. Moreover, bran can reduce your body's ability to absorb calcium, magnesium, iron and zinc. Phytate (phytic acid) found in cereal fiber (bran) also binds with calcium, iron and zinc making them indigestible, which in turn causes malabsorption. Bran has also been shown to cause faecal losses of calcium, iron, zinc, phosphorus, nitrogen, fats, fatty acids and sterols, thus depleting the body of these materials. Cooked bran has even less effect on the intestine than does a comparable amount of raw bran.
  • Husk comes from the seeds from psyllium grain. Some people with irritable bowel syndrome feel worse when taking it and may do better with soluble fiber found in fruits, dried fruits and vegetables. People with an obstruction of the bowel or people with diabetes who have difficulty regulating their blood sugar should not use psyllium at all. Psyllium can also cause gas, and a laxative a day may keep some people in the bathroom all day. Psyllium is contraindicated in those hypersensitive to psyllium or to any component of a psyllium-containing product. It is also contraindicated in those with intestinal obstruction, fecal impaction, difficulty in swallowing and esophageal narrowing. Therefore supplemental psyllium must be taken with adequate amounts of fluids. Inadequate fluid intake may cause psyllium to swell and block the throat, esophagus or intestines.
  • bran and husk are not entirely safe as laxative because of potential health risk and adverse side-effects.
  • its administration must be limited to a certain period of time and treatment for children and elderly people should be supervised by health specialist.
  • the present invention comprehends a natural laxative composition which is prepared from the following ingredients: dried stone-out prunes, seedless raisins, dried stone-out apricots, dried stone-out dates, dried figs, olive oil, grape seed oil, dried alexandrian senna and honey.
  • the present invention proposes the senna-based composition which contains high amount of specifically selected ingredients high in potassium in order to maintain the levels of potassium ions (K+) in the colonic mucus and to counteract the negative effect of senna on colonic potassium ions and to prevent 'lazy-bowel syndrome'.
  • the present invention proposes a laxative composition that contains high amounts of natural soluble and insoluble fiber other than bran and husk in composition with senna herb. Due to large amount and high moisture, fiber from dried fruits produces fast and effective bulk-forming action combined with stimulating effect of senna herb.
  • the present invention proposes laxative composition that does not require any fluid intake. Also unlike most of the bulk-forming medicines, it does not require gradual increase in the intake amount and it starts working next day.
  • the present invention is a laxative composition that contains full spectrum of nutritional elements such as vitamins, minerals, carbohydrates, fats and proteins needed for healthy nutritious balance in the body.
  • the laxative composition contains only natural ingredients and contains no chemical components, preservatives, salt, sugar, lactose, starch, glycerine, gluten, or other added elements, which means healthier choice for customers.
  • Figl is a detailed view of macro nutrients content in given invention presented in the table format.
  • Fig2 is a detailed view of micro nutrients content in given invention presented in the table format.
  • the proposed invention comprises of the following ingredients: dried stone-out prunes: (45Og), seedless raisins (50g), dried stone-out apricots (500g), dried stone-out dates (50g), dried figs (45Og), olive oil (125g), grape seed oil (125g), dried alexandrian senna(400g) and honey (10Og).
  • Dried fruits are rich source of natural dietary fiber therefore make primary contribution into bulk-forming properties of this laxative preparation.
  • Prunes, apricots and figs have high moisture content and are very rich in soluble and insoluble fiber (Figure 1). Thanks to their high moisture and fiber content and large amounts of the stool- loosening sugars such as sorbitol or fructose, they prevent constipation and have the ability to move the intestines.
  • insoluble fiber found in these dried fruits also provides food for the 'friendly' bacteria in the large intestine.
  • butyric acid which serves as the primary fuel for the cells of the large intestine and helps maintain a healthy colon.
  • Dates are highly beneficial in the treatment of constipation as the roughage provided by it stimulates sluggish bowels. They help the intestine perform their function effectively and establish a colony of friendly bacteria in the intestines.
  • Raisins are one of the few fruits that contain a reasonable level of tartaric acid that works together with fiber to help proper elimination of old fecal masses and help keep the colon healthy. Raisins decrease transit time and an increase in fecal weigh. They also reduce concentration of bile acids in the stools.
  • Figs olive oil, grapeseed oil and honey aid digestion by cleansing and soothing the intestine. Due to their properties this laxative preparation is easily digested by sensitive stomach and doesn't cause problems during administration in contrast to senna laxatives manufactured in the form of tablets, capsules and powder. This is important feature particularly when laxative composition is administered by children from 6 years old and elderly people. Not only olive oil, grape seed oil and honey are tolerated well by the stomach but they also produce a positive effect on constipation. Olive oil activates the secretion of bile and pancreatic hormones, lowers the incidence of gallstones and increases the laxative strength and colon cleansing properties of the whole composition.
  • Grape seed oil is ecologically sound product which is low in saturated fat, contains natural chlorophyll and valuable antioxidants.
  • Honey has a bactericidal effect on various gut bacteria known to cause diarrhoea and dysentery. Because sugar molecules in honey can convert into other sugars (e.g. fructose to glucose), honey is easily digested by the most sensitive stomachs, despite its high acid content. It helps kidneys and intestines to function better. Hence honey is beneficial for maintaining a healthy digestive system as well as combating illnesses such as constipation.
  • Present invention contains wide spectrum of nutritional elements such as vitamins, minerals, carbohydrates, fats and proteins needed for healthy nutritious balance in the body. All of the dried fruits contained in the present invention have high amounts of iron, potassium, magnesium, copper and other valuable nutrients (Figure 2). High content of potassium contained in dried fruits will maintain the balance of potassium ions (K+) in the colonic mucus and counteract the negative effect of senna on colonic potassium ions and to prevent 'lazy-bowel syndrome'. By largely eliminating the risk of potassium depletion, this composition can be safely administered for longer periods of time not only by adults but also by children from age of six and elderly people. Also, high concentration of potassium and vitamin A in prunes, dates, figs, raisins and apricots stimulates enzymatic processes. These processes melt down fecal wall wastes and dissolve blockages. Lastly, high concentration of potassium prevents fluid retention caused by constipation.
  • both olive oil and grape seed oil uniquely enhance the flavors of ingredients instead of overpowering them and leave no greasy aftertaste. Due to smoothness of oils, high content of glucose and fructose, individual natural taste of each type of dried fruit present composition has delicious and sweet taste for pleasant and easy administration by both children and adults.
  • the resulting composition is placed into suitable plastic or glass container and is ready for administration.
  • Normal intake dose is one tea-spoon before sleep, but it can be increased or reduced depending on the severity of the constipation.
  • Due to high- moisture and high natural fiber content present invention doesn't require any fluid intake before or after administration in contrast to existing bulk- forming laxatives.
  • This laxative preparation starts working the next day without need to gradually increase the dosage for effective constipation relief.
  • the medicine can be taken up to 30 days to bring deep colon cleansing effect and restore natural bowel movement without developing dependency and causing adverse side-effects.
  • the above-described composition can also be developed into various forms such as: liquid, powder for dilution, bar, easy-to-swallow encapsulated powder, and other various dosage forms that may be applicable to those ingredients.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Insects & Arthropods (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une composition laxative naturelle destinée à traiter et prévenir la constipation par une action de nettoyage du côlon. L'invention se rapporte au domaine de la médecine gastro-intestinale et à la composition laxative naturelle précitée. On prépare ladite composition à partir des ingrédients suivants: des pruneaux dénoyautés, des raisins secs sans pépins, des abricots séchés dénoyautés, des figues séchées, de l'huile d'olive, de l'huile de pépins de raisin, des fruits séchés du séné d'Alexandrie et du miel. La composition laxative de l'invention est utilisée principalement pour le traitement et la prévention efficaces de la constipation à divers degrés de gravité. La composition peut également être utilisée pour nettoyer les intestins en éliminant les fécalomes, ce qui permet d'améliorer la digestion et d'obtenir une défécation régulière.
PCT/GB2008/050071 2007-02-07 2008-02-06 Composition laxative naturelle destinée à traiter et prévenir la constipation par une action de nettoyage du côlon Ceased WO2008096171A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0702335.1 2007-02-07
GB0702335A GB2446373B (en) 2007-02-07 2007-02-07 Natural laxative composition for treating and preventing constipation with colon cleansing action

Publications (2)

Publication Number Publication Date
WO2008096171A2 true WO2008096171A2 (fr) 2008-08-14
WO2008096171A3 WO2008096171A3 (fr) 2009-09-11

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PCT/GB2008/050071 Ceased WO2008096171A2 (fr) 2007-02-07 2008-02-06 Composition laxative naturelle destinée à traiter et prévenir la constipation par une action de nettoyage du côlon

Country Status (2)

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GB (1) GB2446373B (fr)
WO (1) WO2008096171A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102228717A (zh) * 2011-06-27 2011-11-02 青岛市第六人民医院 一种医用复合功能油纱及其制备方法
CN102552475A (zh) * 2012-03-16 2012-07-11 任兆禄 通便栓
CN103638244A (zh) * 2013-11-26 2014-03-19 宋爱民 治疗脾约便秘的中药制剂
CN118020926A (zh) * 2024-03-20 2024-05-14 伊宁市秋乐科农业科技开发有限公司 一种润肠通便保健食品及其制备方法
US12168031B1 (en) 2024-01-11 2024-12-17 Behrouz Maraghechi De-constipation method

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB530455A (en) * 1938-06-29 1940-12-12 Orgachemia Nv Laxative preparations
FR2047M (fr) * 1962-07-02 1963-09-30 Andre Roberti Compositions laxatives ingérables.
US4476121A (en) * 1983-03-01 1984-10-09 Moss David W Bowel evacuant and method of treating constipation
RU2134044C1 (ru) * 1997-07-31 1999-08-10 Закрытое акционерное общество "Эвалар" Биологически активная добавка к пище "фитолакс" и способ ее получения
CN1257735A (zh) * 1999-12-29 2000-06-28 任炎午 一种治疗便秘的药物及其制备方法
RU2189242C1 (ru) * 2001-07-23 2002-09-20 Яковлев Алексей Александрович Средство для нормализации работы кишечника
BRPI0401302C2 (pt) * 2004-05-07 2009-11-24 Sandra Maria Salles Hanszmann processo de fabricação de purês de frutas e formulações de produtos reguladores intestinais correspondentes

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102228717A (zh) * 2011-06-27 2011-11-02 青岛市第六人民医院 一种医用复合功能油纱及其制备方法
CN102552475A (zh) * 2012-03-16 2012-07-11 任兆禄 通便栓
CN103638244A (zh) * 2013-11-26 2014-03-19 宋爱民 治疗脾约便秘的中药制剂
US12168031B1 (en) 2024-01-11 2024-12-17 Behrouz Maraghechi De-constipation method
CN118020926A (zh) * 2024-03-20 2024-05-14 伊宁市秋乐科农业科技开发有限公司 一种润肠通便保健食品及其制备方法

Also Published As

Publication number Publication date
WO2008096171A3 (fr) 2009-09-11
GB2446373A (en) 2008-08-13
GB0702335D0 (en) 2007-03-21
GB2446373B (en) 2009-04-08

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