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WO2008090989A1 - 油脂含有物あるいは油脂中のドコサヘキサエン酸含有率を増加する方法 - Google Patents

油脂含有物あるいは油脂中のドコサヘキサエン酸含有率を増加する方法 Download PDF

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Publication number
WO2008090989A1
WO2008090989A1 PCT/JP2008/051121 JP2008051121W WO2008090989A1 WO 2008090989 A1 WO2008090989 A1 WO 2008090989A1 JP 2008051121 W JP2008051121 W JP 2008051121W WO 2008090989 A1 WO2008090989 A1 WO 2008090989A1
Authority
WO
WIPO (PCT)
Prior art keywords
fatty acid
fat
unsaturated fatty
highly unsaturated
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/051121
Other languages
English (en)
French (fr)
Inventor
Masahiro Hayashi
Sanae Nakajima
Naoki Nagano
Yosuke Taoka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Miyazaki NUC
Nissui Corp
Original Assignee
Nippon Suisan Kaisha Ltd
University of Miyazaki NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Suisan Kaisha Ltd, University of Miyazaki NUC filed Critical Nippon Suisan Kaisha Ltd
Priority to EP08703933.5A priority Critical patent/EP2110438B1/en
Priority to US12/524,647 priority patent/US8349595B2/en
Priority to CA2676556A priority patent/CA2676556C/en
Priority to JP2008555117A priority patent/JP5649785B2/ja
Publication of WO2008090989A1 publication Critical patent/WO2008090989A1/ja
Anticipated expiration legal-status Critical
Priority to US13/706,872 priority patent/US20130096332A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434—Docosahexenoic acids [DHA]
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Edible Oils And Fats (AREA)

Abstract

課題：ドコサヘキサエン酸含有率の増加した油脂を提供すること。 解決手段：高度不飽和脂肪酸産生能を有するストラメノパイルを、脂肪酸不飽和化酵素を阻害する物質を含有する培地で培養することを特徴とする、高度不飽和脂肪酸の製造方法、該方法により得られた高度不飽和脂肪酸、特にドコサヘキサエン酸含有率が増加された油脂。ストラメノパイルを、脂肪酸不飽和化酵素を阻害する物質を含有する培地で培養することを特徴とする、ストラメノパイルの高度不飽和脂肪酸産生能の増強方法、該方法により得られた高度不飽和脂肪酸産生能が増強されたストラメノパイル。特に該ストラメノパイルがラビリンチュラ綱に分類される微生物である、該高度不飽和脂肪酸の製造方法、該高度不飽和脂肪酸産生能の増強方法、および該高度不飽和脂肪酸産生能が増強されたストラメノパイル。
PCT/JP2008/051121 2007-01-26 2008-01-25 油脂含有物あるいは油脂中のドコサヘキサエン酸含有率を増加する方法 Ceased WO2008090989A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP08703933.5A EP2110438B1 (en) 2007-01-26 2008-01-25 Method for increasing the content of docosahexaenoic acid in material containing oil-and-fat or oil-and-fat
US12/524,647 US8349595B2 (en) 2007-01-26 2008-01-25 Method for increasing the content of docosahexaenoic acid in fat-containing materials or in fats and oils
CA2676556A CA2676556C (en) 2007-01-26 2008-01-25 Method for increasing the content of docosahexaenoic acid in fat-containing materials or in fats and oils
JP2008555117A JP5649785B2 (ja) 2007-01-26 2008-01-25 油脂含有物あるいは油脂中のドコサヘキサエン酸含有率を増加する方法
US13/706,872 US20130096332A1 (en) 2007-01-26 2012-12-06 Method for increasing the content of docosahexaenoic acid in fat-containing materials or in fats and oils

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-016498 2007-01-26
JP2007016498 2007-01-26

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/706,872 Division US20130096332A1 (en) 2007-01-26 2012-12-06 Method for increasing the content of docosahexaenoic acid in fat-containing materials or in fats and oils

Publications (1)

Publication Number Publication Date
WO2008090989A1 true WO2008090989A1 (ja) 2008-07-31

Family

ID=39644563

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/051121 Ceased WO2008090989A1 (ja) 2007-01-26 2008-01-25 油脂含有物あるいは油脂中のドコサヘキサエン酸含有率を増加する方法

Country Status (5)

Country Link
US (2) US8349595B2 (ja)
EP (1) EP2110438B1 (ja)
JP (1) JP5649785B2 (ja)
CA (1) CA2676556C (ja)
WO (1) WO2008090989A1 (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010511377A (ja) * 2006-08-01 2010-04-15 オーシャン・ニュートリション・カナダ・リミテッド 油生産微生物およびその改変方法
KR101068520B1 (ko) 2009-10-07 2011-09-28 대상 주식회사 고함량의 도코사헥사엔산을 함유하는 오메가-3 불포화 지방산을 생산하는 균주 및 이를 이용한 오메가-3 불포화 지방산의 제조방법
US8921069B2 (en) 2005-06-07 2014-12-30 Dsm Nutritional Products Ag Eukaryotic microorganisms for producing lipids and antioxidants
US9873880B2 (en) 2013-03-13 2018-01-23 Dsm Nutritional Products Ag Engineering microorganisms
US9951326B2 (en) 2015-07-13 2018-04-24 MARA Renewables Corporation Enhancing microbial metabolism of C5 organic carbon
US10385370B2 (en) 2016-06-10 2019-08-20 MARA Renewables Corporation Method of making lipids with improved cold flow properties
US11578304B2 (en) 2015-03-26 2023-02-14 MARA Renewables Corporation High density production of biomass and oil using crude glycerol

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013113030A2 (en) * 2012-01-26 2013-08-01 Cornell University Fads regulation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6312290A (ja) 1985-10-01 1988-01-19 Lion Corp アラキドン酸含有脂質の製造方法
JPS6344891A (ja) 1986-03-31 1988-02-25 Suntory Ltd アラキドン酸及びこれを含有する脂質の製造方法
JP2006230403A (ja) * 2005-01-31 2006-09-07 Hokkaido Univ ドコサヘキサエン酸（ｄｈａ）の生産性の高い新規ラビリンチュラ類微生物およびその利用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6312290A (ja) 1985-10-01 1988-01-19 Lion Corp アラキドン酸含有脂質の製造方法
JPS6344891A (ja) 1986-03-31 1988-02-25 Suntory Ltd アラキドン酸及びこれを含有する脂質の製造方法
JP2006230403A (ja) * 2005-01-31 2006-09-07 Hokkaido Univ ドコサヘキサエン酸（ｄｈａ）の生産性の高い新規ラビリンチュラ類微生物およびその利用

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
FUJIKAWA S.: "Tokushu Shishitsu Kogaku Saizensen Biseibutsu Yushi no Seisan to Sono Riyo", KAGAKU TO KOGYO, vol. 74, no. 1, 2000, pages 26 - 32, XP008111128 *
NAKAHARA ET AL., JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY, vol. 73, 1996, pages 1421 - 1426
See also references of EP2110438A4
SHIMIZU S ET AL.: "SESAMIN IS A POTENT AND SPECIFIC INHIBITOR OF DELTA5 DESATURASE IN POLYUNSATURATED FATTY ACID BIOSYNTHESIS", LIPIDS, vol. 26, no. 7, 1 January 1991 (1991-01-01), XP002910626, DOI: doi:10.1007/BF02536595
SHIMIZU S.: "Yuryo Biseibutsu no Tansaku.Kaihatsu.Ikushu to Kinosei Shishitsu Seisan eno Riyo", BIOSCIENCE & INDUSTRY, vol. 62, no. 1, 2004, pages 11 - 16, XP002999817 *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10435725B2 (en) 2005-06-07 2019-10-08 Dsm Nutritional Products Ag Eukaryotic microorganisms for producing lipids and antioxidants
US8921069B2 (en) 2005-06-07 2014-12-30 Dsm Nutritional Products Ag Eukaryotic microorganisms for producing lipids and antioxidants
US9719116B2 (en) 2005-06-07 2017-08-01 Dsm Nutritional Prodcuts Ag Eukaryotic microorganisms for producing lipids and antioxidants
US9023616B2 (en) 2006-08-01 2015-05-05 Dsm Nutritional Products Ag Oil producing microbes and method of modification thereof
JP2010511377A (ja) * 2006-08-01 2010-04-15 オーシャン・ニュートリション・カナダ・リミテッド 油生産微生物およびその改変方法
KR101068520B1 (ko) 2009-10-07 2011-09-28 대상 주식회사 고함량의 도코사헥사엔산을 함유하는 오메가-3 불포화 지방산을 생산하는 균주 및 이를 이용한 오메가-3 불포화 지방산의 제조방법
US9873880B2 (en) 2013-03-13 2018-01-23 Dsm Nutritional Products Ag Engineering microorganisms
US11578304B2 (en) 2015-03-26 2023-02-14 MARA Renewables Corporation High density production of biomass and oil using crude glycerol
US9951326B2 (en) 2015-07-13 2018-04-24 MARA Renewables Corporation Enhancing microbial metabolism of C5 organic carbon
US10662418B2 (en) 2015-07-13 2020-05-26 MARA Renewables Corporation Enhancing microbial metabolism of C5 organic carbon
US10851395B2 (en) 2016-06-10 2020-12-01 MARA Renewables Corporation Method of making lipids with improved cold flow properties
US10385370B2 (en) 2016-06-10 2019-08-20 MARA Renewables Corporation Method of making lipids with improved cold flow properties
US11959120B2 (en) 2016-06-10 2024-04-16 MARA Renewables Corporation Method of making lipids with improved cold flow properties

Also Published As

Publication number Publication date
US20130096332A1 (en) 2013-04-18
US8349595B2 (en) 2013-01-08
CA2676556A1 (en) 2008-07-31
EP2110438A1 (en) 2009-10-21
JP5649785B2 (ja) 2015-01-07
EP2110438A4 (en) 2010-03-31
CA2676556C (en) 2016-01-19
US20100099901A1 (en) 2010-04-22
EP2110438B1 (en) 2014-06-25
JPWO2008090989A1 (ja) 2010-05-20

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