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WO2008087665A3 - Procédé de préparation de lansoprazole - Google Patents

Procédé de préparation de lansoprazole Download PDF

Info

Publication number
WO2008087665A3
WO2008087665A3 PCT/IN2008/000034 IN2008000034W WO2008087665A3 WO 2008087665 A3 WO2008087665 A3 WO 2008087665A3 IN 2008000034 W IN2008000034 W IN 2008000034W WO 2008087665 A3 WO2008087665 A3 WO 2008087665A3
Authority
WO
WIPO (PCT)
Prior art keywords
lansoprazole
water
amide
slurry
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2008/000034
Other languages
English (en)
Other versions
WO2008087665A2 (fr
Inventor
Mohan Bandari
Chandra Ray Purna
Kumar Sethi Madhuresh
Venkata Lakshmi Narayana Chebolu Veera
Ramakrishna Kamatam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mylan Laboratories Ltd
Original Assignee
Matrix Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Laboratories Ltd filed Critical Matrix Laboratories Ltd
Publication of WO2008087665A2 publication Critical patent/WO2008087665A2/fr
Anticipated expiration legal-status Critical
Publication of WO2008087665A3 publication Critical patent/WO2008087665A3/fr
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne un procédé de préparation de lansoprazole comprenant les étapes suivantes : oxydation de 2-[[(3-methyl-4-(2,2,2-trifluoroethoxy)pyridinyl]methyl]thio]-lH- benzimidazole au moyen d'un agent d'oxydation, lavage de la masse de réaction au moyen d'une solution aqueuse de tampon, bicarbonate et thiosulphate alcalins, isolation du produit par refroidissement à une basse température en présence d'eau, d'une base, d'un amide ou d'un mélange de ceux-ci. L'invention concerne également une préparation en suspension/cristalline formée à partir d'un solvant organique non miscible dans l'eau en présence d'eau, d'une base, d'un amide ou d'un mélange de ceux-ci. La mise en suspension du produit au moyen d'une solution de bicarbonate de sodium est suivie du séchage de produits secondaires du lansoprazole.
PCT/IN2008/000034 2007-01-18 2008-01-18 Procédé de préparation de lansoprazole Ceased WO2008087665A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN103/CHE/2007 2007-01-18
IN103CH2007 2007-01-18

Publications (2)

Publication Number Publication Date
WO2008087665A2 WO2008087665A2 (fr) 2008-07-24
WO2008087665A3 true WO2008087665A3 (fr) 2011-01-27

Family

ID=39636478

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000034 Ceased WO2008087665A2 (fr) 2007-01-18 2008-01-18 Procédé de préparation de lansoprazole

Country Status (1)

Country Link
WO (1) WO2008087665A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2767516C (fr) 2009-07-07 2018-11-06 Council Of Scientific & Industrial Research Procedes a ecoulement continu servant a la preparation de derives de benzimidazole et de 2-pyridinylmethylsulfinyl imidazo[4,5-b]pyridine
CN107964005A (zh) * 2017-11-10 2018-04-27 扬子江药业集团江苏海慈生物药业有限公司 一种兰索拉唑的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4628098A (en) * 1984-08-16 1986-12-09 Takeda Chemical Industries, Ltd. 2-[2-pyridylmethylthio-(sulfinyl)]benzimidazoles
WO2004018454A1 (fr) * 2002-08-21 2004-03-04 Teva Pharmaceutical Industries Ltd. Procede de purification de lansoprazole
US20040049045A1 (en) * 2000-12-01 2004-03-11 Hideo Hashimoto Process for the crystallization of (r)-or (s)-lansoprazole

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4628098A (en) * 1984-08-16 1986-12-09 Takeda Chemical Industries, Ltd. 2-[2-pyridylmethylthio-(sulfinyl)]benzimidazoles
US20040049045A1 (en) * 2000-12-01 2004-03-11 Hideo Hashimoto Process for the crystallization of (r)-or (s)-lansoprazole
WO2004018454A1 (fr) * 2002-08-21 2004-03-04 Teva Pharmaceutical Industries Ltd. Procede de purification de lansoprazole

Also Published As

Publication number Publication date
WO2008087665A2 (fr) 2008-07-24

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