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WO2008083875A1 - Dispositif d'information - Google Patents

Dispositif d'information Download PDF

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Publication number
WO2008083875A1
WO2008083875A1 PCT/EP2007/062669 EP2007062669W WO2008083875A1 WO 2008083875 A1 WO2008083875 A1 WO 2008083875A1 EP 2007062669 W EP2007062669 W EP 2007062669W WO 2008083875 A1 WO2008083875 A1 WO 2008083875A1
Authority
WO
WIPO (PCT)
Prior art keywords
medicament
housing
patient
unbalance
dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2007/062669
Other languages
English (en)
Inventor
Istvan Bartha
Victor Kronestedt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHL Medical AB
Original Assignee
SHL Medical AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHL Medical AB filed Critical SHL Medical AB
Publication of WO2008083875A1 publication Critical patent/WO2008083875A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/3157—Means providing feedback signals when administration is completed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31586—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by rotationally moving or pivoted actuator, e.g. an injection lever or handle

Definitions

  • the present invention relates medical delivery devices and in particular a device capable of informing a user regarding the status of the delivery device.
  • One type of such delivery devices is an injector capable of delivering doses of medicament, having functions such as penetration of the patient's skin and a subsequent injection of medicament.
  • One such device is for example disclosed in the document EP 1349590, comprising an activation mechanism in the form of a button placed at its distal end. The button may only activate the mechanism if the front end of the device is pressed against an injection site. When done so and the button is pressed, the penetration mechanism inside the injector is released whereby the needle is pushed into the body of the patient. After this, the injection is performed.
  • the patient withdraws the injector with the needle from the injection site, whereby a needle shield is pushed forward until it surrounds the needle and is then locked.
  • US 6,221 ,046 describes an injection device having an 'end of injection click' including an extension on a flexible tab of a dose dial mechanism. The tab with the extension falls into a groove in the housing, causing an audible click at the end of injection.
  • US 2004/0097883 discloses a similar end of injection click solution.
  • US 2004/0267208 discloses an injector having audible and tactile feedback of a dose being dialled, by a clicker and a clutch means having saw teeth that cooperate to create the audible and tactile information.
  • WO 2004/078226 and WO 2006/052737 disclose an injector having tactile and audible feedback on the injection progress.
  • the aim of the present invention is to provide information regarding the delivering process of a medical delivery device in a reliable and predictive way that is easily detectable by any user.
  • a medical delivery device comprising a housing; a container containing medicament arranged inside the housing; a medicament delivery means in communication with the housing and capable of delivering medicament to a patient; force means capable of acting inside the container for delivering medicament during a certain time period via the medicament delivery means; mechanical information means acting in response to the force means; wherein said mechanical information means comprises vibrating means having at least one unbalance member capable of causing a vibrating sensation to the housing for providing tactile information to a patient during the time period, indicating medicament delivery to the patient.
  • the unbalance member is arranged as a rotating unbalance member or as a pivoting unbalance member.
  • the medical delivery device further comprises a turnable dose setting mechanism, which dose setting mechanism rotates back to its original position during medicament delivery, and whereby said rotating unbalance is rotatably connected to the dose setting mechanism.
  • the vibrating means comprises a ratchet arranged on a longitudinally movable plunger rod which is a part of the force means and a ledge which is part of the pivoting unbalance member, and wherein the ledge is arranged to be contact with the ratchet, such that during medicament delivery they move in relation to each other allowing the pivoting unbalance member to be moved.
  • the advantage with the present invention is as follows. Because the device is arranged with tactile mechanical information means that are acting during the delivering process, a user, even with reduced hearing, is able to gain information of the start, progress and stop of the delivering, and is well aware when it is safe to withdraw the device from e.g. an injection site.
  • a vibration is created in the device that can be sensed via the housing and transferred to the hand of the user.
  • the vibrating means comprise an unbalance, which is a good vibration creator, and in particular when the medical delivery device is arranged with rotating components for delivering a dose, or a ratchet means, which is suitable when longitudinally moving components are used for delivering a dose.
  • FIG. 1 shows one embodiment in cross-section of a medical delivery device comprising the present invention
  • Fig. 2 shows a cross-sectional view of Fig. 1 .
  • FIG. 3 shows a detailed view of a further embodiment of the present invention, in perspective,
  • Fig. 4 shows the embodiment of Fig. 3 in three side views
  • FIG. 5 shows yet an embodiment of the present invention in perspective
  • Fig. 6 shows the embodiment of Fig. 5 in a side view.
  • FIG. 7 shows the embodiment of Fig. 5 in cross-section of a medical delivery device comprising the present invention.
  • Figure 1 shows a cross-sectional view of a medical delivery device, as an example of a delivery device, comprising the present invention.
  • the delivery device comprises a dose setting member, to the right in Fig. 1 , which hereafter will be named the distal end.
  • the opposite end of the device, to the left in the figure, is the end which is closest to the patient during medicament delivery, and will be named the proximal end.
  • the device is arranged with a container housing.
  • the delivery device 2 comprises in its distal end a dose setting mechanism and in its proximal end a container 10, e.g. a cartridge, a syringe, an ampoule, or the like having at least one chamber, coupled to an outer cover 40.
  • the container 10 is intended to be filled with a medicament to be administered to the patient and the delivery device is thus provided with means in order to be connected to a suitable medicament administrating member, e.g.
  • a mouth, a nasal piece a member that introduces the medicament to the eye of a patient, a suitable nozzle that sprays the medicament to the eye, a spray nozzle to spray the medicament onto the skin of a patient or a needle for the injection of a medicament into the body of a patient; wherein the medicament is a liquid that can have a low or a high viscosity.
  • the dose setting mechanism comprises dose setting a member 4 having a dose wheel turning member 5 and a housing member 6 housing the energy accumulating member (see below), which members are adapted in order to be firmly, and removably, connected with each other.
  • the interior of the proximal part of the dose wheel turning member 5 is provided with a number of equally distributed splines (not shown), which are adapted to engage corresponding inward protruding means (not shown) of the housing member.
  • the housing member 6 is further provided with a shoulder adapted to be in contact with a corresponding means (not shown) in the outer cover of the device (not shown).
  • An elongated screw threaded plunger rod 16 is provided in the interior of the delivery device 2, running along the longitudinal axis of said device 2, which device thus is provided with means in order to house such a screw threaded member 16.
  • the plunger rod 16 is in its proximal end adapted to be in contact with a stopper 22 through a non-rotating means, which stopper 22 is sealingly and slidably provided inside the container 10.
  • the housing member 6 is adapted to house an energy accumulating member in the form of a flat spiral spring 26, which spring 26 is provided winded in layers around the exterior of the proximal part of the housing member 6.
  • the flat spiral spring 26 is in its inner end provided with inner holding means in order to be attached to the housing member 6, such as for instance a protruding member adapted to be fitted with a corresponding slit in the housing member 6, or alternatively a hole of a suitable size in the flat spiral spring 26, and a smaller screw or other similar means for the anchoring of the flat spiral spring 26 in the housing member 6.
  • said flat spiral spring 26 is provided with outer holding means in order to be connected to the flat spiral spring cover of the delivery device 2.
  • Said outer holding means comprises preferably a bend of the outer end of the flat spiral spring 26, which hitches corresponding means in the flat spiral spring cover.
  • the cover is provided with means (not shown) in order to be rotationally fixed in the outer cover.
  • the dose setting member 4 is further in its proximal end adapted to house a coupling member 46.
  • Said coupling member 46 is in its proximal end provided with a crown, which proximal end in turn is provided with at least one, preferably two equally distributed, bevelled protrusions.
  • the crown of the coupling member is adapted to engage a plunger rod driving member 35, e.g. in the form of a nut.
  • the nut is in this case adapted to engage with the plunger rod 16, i.e. the interior of the nut is provided with latches in order to be engaged in corresponding slots on the plunger rod 16.
  • the nut is designed as to in its proximal end be provided with outwardly protruding flanges and in its distal end be provided with a skirt, the distal end of which is provided with a number of equally distributed bevelled recesses, which correspond to the protrusions of the crown.
  • the coupling member is further provided with a helical coupling spring 32, which proximal end is in contact with the distal end of the crown. The proximal end of the coupling spring 32 is firmly fixed to the coupling member 35.
  • the delivery device 2 of the first embodiment is in a locked state, i.e. a non-medicament delivery state, as will be described in further detail below, the nut is held in a locked non- rotatable state by means of an actuation sleeve 50.
  • the interior of said sleeve is for this purpose provided with inward protruding stopper means (not shown), adapted to be provided in between the protruding flanges of the nut.
  • the actuation sleeve is further adapted to engage a dose actuation member (not shown), and is at its distal end provided with means in order to be connected to a helical actuation spring 56, said spring 56 is provided surrounding the distal end of the actuation sleeve and the distal end of the actuation spring 56 is in contact with the outer cover 40.
  • the predetermined dose is in a first dose delivery step set by the use of the dose wheel 5, with the use of which the dose is increased by predetermined equally large dose increment steps.
  • One predetermined dose increment step corresponds to a clock-wise rotation of the dose wheel 5 with one step, which step corresponds to a predetermined number of degrees.
  • the dose wheel is turned clock-wise an additional step corresponding to said predetermined number of degrees.
  • the dose wheel turning member 5 is turned clock- wise two steps.
  • the coupling member rotates clock-wise, the protrusions will move along the bevelled edge of the recesses of the plunger rod driving member, with which recesses the protrusions are initially in engage with, and the coupling member will thus move towards the distal end of the delivery device 2, compress the coupling spring, and unlock the dose wheel from the plunger rod driving member.
  • the flat spiral spring 26 is hereby free to wind up and accumulate energy corresponding to the rotation of the dose wheel turning member 5 the number of degrees corresponding to one clock-wise step turn.
  • the coupling member Due to the power accumulated in the compressed coupling spring 32, the coupling member will now move back towards the proximal end of the delivery device 2 when the protrusions climbs over the edge of the bevelled recesses and lock the coupling member as well as the dose wheel 5 to the plunger rod driving member, when the protrusions engage the recesses following the recesses it was previously in engagement with.
  • the dose wheel turning member 5 is turned the additional and final step, whereby the above described procedure is repeated.
  • the flat spiral spring 26 has thus after the completion of the first dose delivery step, accumulated the energy that corresponds to the rotation of the dose wheel turning member 5 the number of degrees corresponding to a two step clock- wise turn.
  • the delivery device 2 is now ready to deliver the predetermined dose corresponding to two dose increment steps, i.e. the delivery device 2 is now ready to be set in a medicament delivery state. This is accomplished by in a second dose delivery step, activate, i.e. pushing, the dose actuation member.
  • the dose actuation member When the dose actuation member is activated, said actuation member will actuate the actuation sleeve 50 towards the distal end of the device 2, whereby the protruding stopper means of the actuation sleeve 50 and the external means of the plunger rod driving member are brought out of engagement and the plunger rod driving member is released for rotation.
  • the coupling member and the plunger rod driving member will due to the output torque of the spring 26 when said spring now is free to unwind, rotate counter clock-wise the number of degrees corresponding to the two step turn.
  • the rotation of the plunger rod driving member will rotate the plunger rod, and due to the non- rotating means adapted to engage a longitudinal extending means on the plunger rod so that the plunger rod moves towards the proximal end of the container the predetermined distance without rotation.
  • the movement of the plunger rod causes the stopper to move forward in the container, thereby causing medicament contained in the container to be expelled through e.g. a needle and thus perform an injection.
  • the housing member 6 will rotate during this step.
  • the delivery device comprises mechanical information means 100 acting in response to the force means 16, 26.
  • the inner surface of the housing member 6 is arranged with vibrating means, e.g. a circumferentially ratchet 101 and a small cog-wheel 102 arranged rotatably on a shaft 104 and both arranged on a stationary part of the device.
  • the cog-wheel is in engagement with the teeth of the ratchet 101.
  • Said vibrating means comprise further an unbalance member 105 attached to the cog-wheel.
  • the actuation sleeve 50 will, due to the power accumulated in the actuation spring 56 when the actuation sleeve is pushed towards the distal end of the device 2, move back to its original position and once again lock the plunger rod driving member for rotation.
  • the plunger rod 16 will stay at its current position, with its proximal end in contact with the stopper 22, and the delivery device 2 is ready to be used again.
  • FIGS 3 and 4 show a variant of the present invention.
  • said vibrating means comprises e.g. a circumferential ratchet 110 attached to a part rotating during delivering of the delivery device.
  • a small cog-wheel 112 is also arranged to be in engagement with the ratchet, and is thus rotating with a rather high rotational speed when the ratchet is rotating during delivering.
  • On the cog-wheel 112 a further vibrating means is attached, e.g. an unbalance member 114.
  • Said unbalance member 114 is arranged with four 'arms' 116 onto which magnets 118 are placed in a circular pattern with equal pitch.
  • a fixedly arranged magnetic metal member 120 is further arranged adjacent the circular path of the magnets.
  • the magnets will pass the magnetic metal member.
  • Each passing of a magnet will cause a temporary retardation of the cog-wheel, and thus a vibration, that is transmitted to the delivery device, thereby providing the same type of tactile information as described above.
  • the vibrating means comprises a ratchet 132 arranged on a longitudinally movable plunger rod 130 which is a part of the force means and a ledge 134 which is part of a pivoting unbalance member 131 pivoted arranged on a fixed adjacent component of the device e.g. a housing 137, and wherein the ledge 134 is arranged to be contact with the ratchet 132.
  • the pivoting unbalance member 131 comprises the ledge 134 at one end and a massive ledge/head 135 at the opposite end resting against the housing 137.
  • the plunger rod moves in its longitudinal direction, pushing the stopper into the container.
  • the ledge 134 will slide over the ratchet 132 up along one saw-toothed shaped tooth and then down onto the next tooth.
  • This movement will cause the pivoting unbalance member to be moved, e.g. about a pivot 136, allowing the massive ledge/head 135 to vibrate against the housing 137 and will thus provide the same type of tactile information as the previous embodiments.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif de délivrance médicale comprenant un boîtier ; un contenant (10) contenant un médicament disposé dans le boîtier ; un moyen de délivrance du médicament (32, 35, 46, 50, 56) en communication avec le boîtier et capable de délivrer le médicament à un patient ; un moyen d'application d'une force (16, 26 ; 130, 26), capable d'agir à l'intérieur du contenant pour délivrer le médicament pendant une période de temps donnée via le moyen de délivrance du médicament ; un moyen d'information mécanique (100) qui agit en réponse au moyen d'application d'une force ; ledit moyen d'information mécanique comprenant un moyen de vibration (101, 102, 104 ; 110, 112, 132, 134) qui comprend au moins un élément non équilibré capable de conférer une sensation de vibration au boîtier afin de fournir des informations tactiles à un patient pendant la période de temps, indiquant ainsi la délivrance du médicament.
PCT/EP2007/062669 2007-01-09 2007-11-22 Dispositif d'information Ceased WO2008083875A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US88402807P 2007-01-09 2007-01-09
SE0700045 2007-01-09
SE0700045-8 2007-01-09
US60/884,028 2007-01-09

Publications (1)

Publication Number Publication Date
WO2008083875A1 true WO2008083875A1 (fr) 2008-07-17

Family

ID=39145895

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/062669 Ceased WO2008083875A1 (fr) 2007-01-09 2007-11-22 Dispositif d'information

Country Status (1)

Country Link
WO (1) WO2008083875A1 (fr)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009141650A3 (fr) * 2008-05-20 2010-01-21 Owen Mumford Limited Dispositif d'injection
WO2011133089A1 (fr) * 2010-04-19 2011-10-27 Shl Group Ab Dispositif de distribution de médicaments pour auto-administration
WO2012085584A3 (fr) * 2010-12-22 2012-08-16 Owen Mumford Limited Auto-injecteurs
WO2012173554A1 (fr) * 2011-06-17 2012-12-20 Shl Group Ab Dispositif d'injection
EP2583705A1 (fr) 2011-10-21 2013-04-24 Sanofi-Aventis Deutschland GmbH Agencement d'indicateur pour auto-injecteur
WO2013077800A1 (fr) * 2011-11-25 2013-05-30 Shl Group Ab Dispositif de distribution de médicament
CN104168936A (zh) * 2012-03-16 2014-11-26 卡贝欧洲有限公司 药剂输送装置
WO2015074976A1 (fr) * 2013-11-22 2015-05-28 Sanofi-Aventis Deutschland Gmbh Dispositif d'administration de médicament comprenant un élément d'encliquetage d'administration de dose
RU2571332C1 (ru) * 2011-11-25 2015-12-20 Схл Груп Аб Медицинское доставочное устройство
JP2016508774A (ja) * 2013-02-01 2016-03-24 ノボ・ノルデイスク・エー／エス 非軸方向作動型の内容量終了機構、およびこれを備えた注射装置
WO2017089254A1 (fr) * 2015-11-27 2017-06-01 Sanofi-Aventis Deutschland Gmbh Auto-injecteur
KR101825868B1 (ko) 2014-05-01 2018-02-05 뉴 인젝션 시스템즈 엘티디 표시기
CN108136131A (zh) * 2015-09-14 2018-06-08 卡贝欧洲有限公司 药剂输送装置
RU2696451C1 (ru) * 2019-03-27 2019-08-01 Общество с ограниченной ответственностью «НЭКСТ БИО» Шприц-ручка для инъекций
RU2729442C1 (ru) * 2019-10-23 2020-08-06 Общество с ограниченной ответственностью "НЭКСТ БИО" Устройство для доставки лекарственного средства
WO2020172323A1 (fr) * 2019-02-19 2020-08-27 Kwolek Marilyn Exostructure d'assistance pour injection précise avec une seringue
US10881809B2 (en) 2017-08-22 2021-01-05 KB Medical, LLC Exostructure to assist in accurate syringe injection
US11065386B2 (en) 2014-12-03 2021-07-20 Eli Lilly And Company Automatic medication injection device with audible indication of injecting progress
US11123494B2 (en) 2017-08-22 2021-09-21 KB Medical, LLC Exostructure to assist in accurate syringe injection

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US6645167B1 (en) * 1999-05-21 2003-11-11 Micro Therapeutics, Inc. Methods for embolizing vascular sites with an embolizing composition
WO2004078226A2 (fr) * 2003-03-03 2004-09-16 Dca Design International Ltd. Perfectionnements dans des mecanismes de commande destines a etre utilises dans des dispositifs d'administration de medicaments
WO2005097233A2 (fr) * 2004-03-30 2005-10-20 Eli Lilly And Company Appareil d'administration de medicament comprenant une caracteristique de verrouillage au moyen d'un ressort pour l'administration d'une dose finale
WO2006052737A1 (fr) * 2004-11-04 2006-05-18 Sid Technologies, Llc Injecteur automatique
US7081108B2 (en) * 2000-12-22 2006-07-25 Dca Design International Limited Pen-type injector having holding mechanism for medicament cartridge

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999015214A1 (fr) * 1997-09-25 1999-04-01 Disetronic Licensing Ag Dispositif de distribution avec donneur de signaux
US6645167B1 (en) * 1999-05-21 2003-11-11 Micro Therapeutics, Inc. Methods for embolizing vascular sites with an embolizing composition
US7081108B2 (en) * 2000-12-22 2006-07-25 Dca Design International Limited Pen-type injector having holding mechanism for medicament cartridge
WO2004078226A2 (fr) * 2003-03-03 2004-09-16 Dca Design International Ltd. Perfectionnements dans des mecanismes de commande destines a etre utilises dans des dispositifs d'administration de medicaments
WO2005097233A2 (fr) * 2004-03-30 2005-10-20 Eli Lilly And Company Appareil d'administration de medicament comprenant une caracteristique de verrouillage au moyen d'un ressort pour l'administration d'une dose finale
WO2006052737A1 (fr) * 2004-11-04 2006-05-18 Sid Technologies, Llc Injecteur automatique

Cited By (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8721593B2 (en) 2008-05-20 2014-05-13 Owen Mumford Limited Injection device
US20110077599A1 (en) * 2008-05-20 2011-03-31 Owen Mumford Limited Injection device
JP2011520545A (ja) * 2008-05-20 2011-07-21 オーウェン マンフォード リミテッド 注射器具
WO2009141650A3 (fr) * 2008-05-20 2010-01-21 Owen Mumford Limited Dispositif d'injection
WO2011133089A1 (fr) * 2010-04-19 2011-10-27 Shl Group Ab Dispositif de distribution de médicaments pour auto-administration
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