[go: up one dir, main page]

WO2008078742A1 - 蛍光内視鏡および蛍光測定方法 - Google Patents

蛍光内視鏡および蛍光測定方法 Download PDF

Info

Publication number
WO2008078742A1
WO2008078742A1 PCT/JP2007/074835 JP2007074835W WO2008078742A1 WO 2008078742 A1 WO2008078742 A1 WO 2008078742A1 JP 2007074835 W JP2007074835 W JP 2007074835W WO 2008078742 A1 WO2008078742 A1 WO 2008078742A1
Authority
WO
WIPO (PCT)
Prior art keywords
fluorescence
region
interest
determining
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2007/074835
Other languages
English (en)
French (fr)
Inventor
Yasushige Ishihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olympus Corp
Original Assignee
Olympus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olympus Corp filed Critical Olympus Corp
Priority to US12/520,932 priority Critical patent/US8295917B2/en
Publication of WO2008078742A1 publication Critical patent/WO2008078742A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/05—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/07—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7253—Details of waveform analysis characterised by using transforms
    • A61B5/7257—Details of waveform analysis characterised by using transforms using Fourier transforms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Optics & Photonics (AREA)
  • Endoscopes (AREA)

Abstract

　被検体との距離の影響を低減することにより、正常部と病変部との判別を簡便に行うことができる蛍光内視鏡および蛍光測定方法を提供する。被検体に照射する光を出射する光源７と、被検体３から発生した戻り光に含まれる蛍光を撮像する蛍光撮像手段２３と、蛍光撮像手段２３により取得された蛍光に係るデータに基づいて、蛍光画像データを生成する蛍光画像生成手段３７と、蛍光画像データに基づいて、周囲の領域と比較して蛍光強度が高い関心領域を決定する関心領域決定手段３９と、関心領域の近傍の近傍領域を決定する近傍領域決定手段４１と、関心領域における蛍光強度に係る階調と、近傍領域における蛍光強度に係る階調との比に基づいて、修正画像データを生成する画像演算手段４３と、が設けられたことを特徴とする。
PCT/JP2007/074835 2006-12-25 2007-12-25 蛍光内視鏡および蛍光測定方法 Ceased WO2008078742A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/520,932 US8295917B2 (en) 2006-12-25 2007-12-25 Fluorescence endoscope and fluorometry method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006347975A JP5019866B2 (ja) 2006-12-25 2006-12-25 蛍光内視鏡及び蛍光内視鏡の作動方法
JP2006-347975 2006-12-25

Publications (1)

Publication Number Publication Date
WO2008078742A1 true WO2008078742A1 (ja) 2008-07-03

Family

ID=39562531

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/074835 Ceased WO2008078742A1 (ja) 2006-12-25 2007-12-25 蛍光内視鏡および蛍光測定方法

Country Status (3)

Country Link
US (1) US8295917B2 (ja)
JP (1) JP5019866B2 (ja)
WO (1) WO2008078742A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2189099A1 (en) * 2008-11-21 2010-05-26 Fujifilm Corporation Endoscope apparatus and its control method
CN102802494A (zh) * 2010-03-23 2012-11-28 奥林巴斯株式会社 荧光观察装置
US20150216416A1 (en) * 2008-05-27 2015-08-06 Massachusetts Institute Of Technology System and Method for Large Field of View, Single Cell Analysis
US10791937B2 (en) 2013-03-14 2020-10-06 Lumicell, Inc. Medical imaging device and methods of use
US10951800B2 (en) 2017-12-19 2021-03-16 Olympus Corporation Endoscope system and endoscope processor
US11592396B2 (en) 2009-05-27 2023-02-28 Lumicell, Inc. Methods and systems for spatially identifying abnormal cells

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102753079B (zh) * 2010-02-10 2015-06-03 奥林巴斯株式会社 荧光内窥镜装置
JP5555002B2 (ja) * 2010-02-10 2014-07-23 オリンパス株式会社 蛍光内視鏡装置
JP5438635B2 (ja) * 2010-08-31 2014-03-12 富士フイルム株式会社 電子内視鏡システム
JP2012090889A (ja) * 2010-10-28 2012-05-17 Olympus Corp 蛍光観察装置
JP6006199B2 (ja) * 2011-03-31 2016-10-12 オリンパス株式会社 蛍光観察装置
CN103491850B (zh) * 2011-04-28 2016-08-17 奥林巴斯株式会社 荧光观察装置及其图像显示方法
JP5802440B2 (ja) * 2011-06-02 2015-10-28 オリンパス株式会社 蛍光観察装置
JP5926909B2 (ja) 2011-09-07 2016-05-25 オリンパス株式会社 蛍光観察装置
US20150065868A1 (en) * 2012-04-02 2015-03-05 The Research Foundation for the State University New York System, method, and computer accessible medium for volumetric texture analysis for computer aided detection and diagnosis of polyps
NL2009021C2 (en) * 2012-06-18 2013-12-23 Quest Photonic Devices B V Dichroic prism assembly for use in an endoscope tip, method for making said assembly, and endoscope comprising a said assembly.
HK1209309A1 (zh) * 2012-06-27 2016-04-01 曼特瑞斯医药有限责任公司 組織的圖像引導治療
WO2014084134A1 (ja) * 2012-11-30 2014-06-05 オリンパス株式会社 観察装置
JP6030035B2 (ja) * 2013-09-27 2016-11-24 富士フイルム株式会社 蛍光観察装置、内視鏡システム及びプロセッサ装置並びに作動方法
JP6257294B2 (ja) * 2013-12-04 2018-01-10 オリンパス株式会社 顕微鏡装置
CN106455942B (zh) * 2014-06-05 2018-07-06 奥林巴斯株式会社 处理装置、内窥镜装置及系统、图像处理装置的工作方法
EP3141178A4 (en) * 2014-11-26 2018-02-21 Olympus Corporation Diagnosis assistance device and diagnosis assistance information display method
WO2016139768A1 (ja) * 2015-03-04 2016-09-09 オリンパス株式会社 画像処理装置、生体観察装置および画像処理方法
CN110337259B (zh) * 2017-02-24 2023-01-06 富士胶片株式会社 内窥镜系统、处理器装置及内窥镜系统的工作方法
CN110892251B (zh) * 2017-07-11 2023-09-15 浜松光子学株式会社 试样观察装置和试样观察方法
WO2019049376A1 (ja) * 2017-09-11 2019-03-14 オリンパス株式会社 内視鏡システム
JP6978604B2 (ja) * 2018-07-10 2021-12-08 オリンパス株式会社 内視鏡装置、内視鏡装置の作動方法及びプログラム
EP3890583B1 (en) * 2018-12-05 2025-09-24 Intuitive Surgical Operations, Inc. Illumination corrected near-infrared (nir) imaging for image guided surgery
JP6807605B6 (ja) * 2018-12-27 2021-03-31 孝彦 柴原 口腔検診支援システム
DE102019131650A1 (de) * 2019-11-22 2021-05-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zum Ermitteln und Optimieren des Gehalts von wenigstens einem Pflanzeninhaltsstoff von wenigstens einem Teil einer Pflanze
US20230238135A1 (en) * 2020-06-19 2023-07-27 The General Hospital Corporation Near-infrared autofluorescence imaging systems and methods
CN115656130B (zh) * 2022-10-29 2024-10-29 深圳大学 一种荧光发射比率三维超分辨成像方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003164414A (ja) * 2001-11-29 2003-06-10 Fuji Photo Film Co Ltd 蛍光診断画像表示方法および表示装置
JP2006191989A (ja) * 2005-01-11 2006-07-27 Olympus Corp 蛍光観察内視鏡装置

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6198532B1 (en) * 1991-02-22 2001-03-06 Applied Spectral Imaging Ltd. Spectral bio-imaging of the eye
US5749830A (en) * 1993-12-03 1998-05-12 Olympus Optical Co., Ltd. Fluorescent endoscope apparatus
US7328059B2 (en) * 1996-08-23 2008-02-05 The Texas A & M University System Imaging of light scattering tissues with fluorescent contrast agents
JP3417246B2 (ja) * 1996-09-25 2003-06-16 日本電気株式会社 階調表示方法
US6364829B1 (en) * 1999-01-26 2002-04-02 Newton Laboratories, Inc. Autofluorescence imaging system for endoscopy
US6276798B1 (en) * 1998-09-29 2001-08-21 Applied Spectral Imaging, Ltd. Spectral bio-imaging of the eye
JP2001137173A (ja) 1999-11-11 2001-05-22 Fuji Photo Film Co Ltd 蛍光画像測定方法および装置
US7123756B2 (en) * 2001-04-27 2006-10-17 Fuji Photo Film Co., Ltd. Method and apparatus for standardized fluorescence image generation
US6521394B1 (en) * 2001-12-28 2003-02-18 Eastman Kodak Company Fluorescent photothermographic imaging element comprising coupling agent
JP4142326B2 (ja) 2002-04-05 2008-09-03 Ｈｏｙａ株式会社 自家蛍光を利用した診断システム
JP2004024392A (ja) 2002-06-24 2004-01-29 Pentax Corp 蛍光診断補助装置

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003164414A (ja) * 2001-11-29 2003-06-10 Fuji Photo Film Co Ltd 蛍光診断画像表示方法および表示装置
JP2006191989A (ja) * 2005-01-11 2006-07-27 Olympus Corp 蛍光観察内視鏡装置

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150216416A1 (en) * 2008-05-27 2015-08-06 Massachusetts Institute Of Technology System and Method for Large Field of View, Single Cell Analysis
US11266313B2 (en) * 2008-05-27 2022-03-08 Massachusetts Institute Of Technology System and method for large field of view, single cell analysis
EP2189099A1 (en) * 2008-11-21 2010-05-26 Fujifilm Corporation Endoscope apparatus and its control method
US8439823B2 (en) 2008-11-21 2013-05-14 Fujifilm Corporation Endoscope apparatus and its control method
US11592396B2 (en) 2009-05-27 2023-02-28 Lumicell, Inc. Methods and systems for spatially identifying abnormal cells
US12163887B2 (en) 2009-05-27 2024-12-10 Lumicell, Inc. Methods and systems for spatially identifying abnormal cells
CN102802494A (zh) * 2010-03-23 2012-11-28 奥林巴斯株式会社 荧光观察装置
CN102802494B (zh) * 2010-03-23 2015-04-29 奥林巴斯株式会社 荧光观察装置
US10791937B2 (en) 2013-03-14 2020-10-06 Lumicell, Inc. Medical imaging device and methods of use
US11471056B2 (en) 2013-03-14 2022-10-18 Lumicell, Inc. Medical imaging device and methods of use
US10951800B2 (en) 2017-12-19 2021-03-16 Olympus Corporation Endoscope system and endoscope processor

Also Published As

Publication number Publication date
US8295917B2 (en) 2012-10-23
JP2008154846A (ja) 2008-07-10
JP5019866B2 (ja) 2012-09-05
US20100049058A1 (en) 2010-02-25

Similar Documents

Publication Publication Date Title
WO2008078742A1 (ja) 蛍光内視鏡および蛍光測定方法
EP1561420A3 (en) Lesion identification system for surgical operation and related method
US9182347B2 (en) Fluoroscopy apparatus, fluoroscopy system, and fluorescence-image processing method
US9052286B2 (en) Fluorescence endoscope apparatus
EP1929930A4 (en) ENDOSCOPIC DEVICE
US9532719B2 (en) Fluorescence endoscope apparatus
US7667180B2 (en) Image capturing system, image capturing method, and recording medium
JP5376206B2 (ja) 位置特定システムおよびプログラム
EP2301416A8 (en) Method of controlling endoscope and endoscope
WO2008088002A1 (ja) 蛍光観察装置および蛍光観察方法
EP2127592A4 (en) INTRODUCTION SYSTEM IN A SUBJECT
EP1747751A3 (en) Optical diagnosis and treatment apparatus
JPWO2018159363A1 (ja) 内視鏡システム及びその作動方法
CN103200857B (zh) 荧光观察装置
EP1692995A4 (en) Borescope
EP1669019A3 (en) Fluorescence endoscopy device
JP2009153970A (ja) 画像処理システム、画像処理方法、およびプログラム
EP1894524A4 (en) VEIN AUTHENTICATION DEVICE
WO2008008231A3 (en) Systems and methods for generating fluorescent light images
JP5335017B2 (ja) 内視鏡装置
WO2006120690A3 (en) Endoscopic measurement techniques
WO2008093746A1 (ja) 蛍光観察装置および蛍光観察方法
EP1800595A3 (en) Endoscope and image processing device
ATE375749T1 (de) Vorrichtung zur durchführung von intra-operativer angiographie
EP2191774A3 (en) Systems and methods for in-vivo optical imaging and measurement

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07860064

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 12520932

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07860064

Country of ref document: EP

Kind code of ref document: A1