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WO2008077406A3 - Coupling of elements - Google Patents

Coupling of elements Download PDF

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Publication number
WO2008077406A3
WO2008077406A3 PCT/DK2007/000569 DK2007000569W WO2008077406A3 WO 2008077406 A3 WO2008077406 A3 WO 2008077406A3 DK 2007000569 W DK2007000569 W DK 2007000569W WO 2008077406 A3 WO2008077406 A3 WO 2008077406A3
Authority
WO
WIPO (PCT)
Prior art keywords
elements
coupling
peptide
disulfide bridge
irradiated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DK2007/000569
Other languages
French (fr)
Other versions
WO2008077406A2 (en
Inventor
Maria Teresa Petersen
Steffen Bjoern Petersen
Laurent Duroux
Meg Duroux
Esben Skovsen
Jon Weis Stranddorf
Rasmus Lybech Jensen
Lars Wagner Staede
Rune Wiik Andersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BionanoPhotonics AS
Original Assignee
BionanoPhotonics AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BionanoPhotonics AS filed Critical BionanoPhotonics AS
Publication of WO2008077406A2 publication Critical patent/WO2008077406A2/en
Publication of WO2008077406A3 publication Critical patent/WO2008077406A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/14—Peptides being immobilised on, or in, an inorganic carrier

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to a method of light-induced coupling two elements A and B via thiol binding. According to the method, molecules, proteins, peptides or peptide-containing elements can be coupled to a support or to a second molecule, protein, peptide or peptide-containing element, where the structural and functional properties of the coupled or immobilised elements are preserved, and the orientation of coupling can be controlled on a molecular scale. In particular, the method comprises generating an element A* by providing an appropriate disulfide bridge or disulfide bridge-containing triad to said element A, irradiating element A* to create an appropriate reactive thiol group from the disulfide bridge, and incubating the irradiated element A* with said element B, thereby a coupling between element A and element B is obtained. Alternatively, element A* can also be irradiated in the presence of B.
PCT/DK2007/000569 2006-12-22 2007-12-21 Coupling of elements Ceased WO2008077406A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87667306P 2006-12-22 2006-12-22
US60/876,673 2006-12-22

Publications (2)

Publication Number Publication Date
WO2008077406A2 WO2008077406A2 (en) 2008-07-03
WO2008077406A3 true WO2008077406A3 (en) 2008-08-21

Family

ID=39415145

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2007/000569 Ceased WO2008077406A2 (en) 2006-12-22 2007-12-21 Coupling of elements

Country Status (1)

Country Link
WO (1) WO2008077406A2 (en)

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US8034396B2 (en) 2008-04-01 2011-10-11 Tyco Healthcare Group Lp Bioadhesive composition formed using click chemistry
AU2010215203B2 (en) 2009-02-21 2015-07-16 Covidien Lp Medical devices with an activated coating
US8535477B2 (en) 2009-02-21 2013-09-17 Sofradim Production Medical devices incorporating functional adhesives
US8969473B2 (en) 2009-02-21 2015-03-03 Sofradim Production Compounds and medical devices activated with solvophobic linkers
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US8877170B2 (en) 2009-02-21 2014-11-04 Sofradim Production Medical device with inflammatory response-reducing coating
US8968733B2 (en) 2009-02-21 2015-03-03 Sofradim Production Functionalized surgical adhesives
US8663689B2 (en) 2009-02-21 2014-03-04 Sofradim Production Functionalized adhesive medical gel
US8512728B2 (en) 2009-02-21 2013-08-20 Sofradim Production Method of forming a medical device on biological tissue
WO2010095053A2 (en) 2009-02-21 2010-08-26 Sofradim Production Apparatus and method of reaching polymers by exposure to uv radiation to produce injectable medical devices
US9555154B2 (en) 2009-02-21 2017-01-31 Covidien Lp Medical devices having activated surfaces
CA2753189A1 (en) 2009-02-21 2010-08-26 Nadya Belcheva Medical devices having activated surfaces
US8648144B2 (en) 2009-02-21 2014-02-11 Sofradim Production Crosslinked fibers and method of making same by extrusion
EP2398583B1 (en) 2009-02-21 2020-12-23 Sofradim Production Apparatus and method of reacting polymers passing through metal ion matrix to produce injectable medical devices
EP2398943B1 (en) 2009-02-21 2013-04-17 Sofradim Production Crosslinked fibers and method of making same using uv radiation
US9272074B2 (en) 2010-03-25 2016-03-01 Sofradim Production Surgical fasteners and methods for sealing wounds
WO2011117744A2 (en) 2010-03-25 2011-09-29 Sofradim Production Medical devices incorporating functional adhesives
AU2011276443A1 (en) 2010-06-29 2013-01-31 Covidien Lp Microwave-powered reactor and method for in situ forming implants
EP2588153A2 (en) 2010-07-01 2013-05-08 Sofradim Production Medical device with predefined activated cellular integration
CA2805987C (en) 2010-07-27 2019-04-09 Sofradim Production Polymeric fibers having tissue reactive members
US9775928B2 (en) 2013-06-18 2017-10-03 Covidien Lp Adhesive barbed filament
CN105296517B (en) * 2015-11-05 2018-12-28 盘古基因生物工程(南京)股份有限公司 A kind of fusion protein expression vector of companion's sample albumen

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994001773A1 (en) * 1992-07-06 1994-01-20 Biomira Inc. Photoactivation of proteins for conjugation purposes
WO2004065928A2 (en) * 2003-01-22 2004-08-05 Bionanophotonics A/S Light induced immobilisation
WO2007000163A1 (en) * 2005-06-27 2007-01-04 Bionanophotonics A/S Immobilisation of polypeptides by irradiation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994001773A1 (en) * 1992-07-06 1994-01-20 Biomira Inc. Photoactivation of proteins for conjugation purposes
WO2004065928A2 (en) * 2003-01-22 2004-08-05 Bionanophotonics A/S Light induced immobilisation
WO2007000163A1 (en) * 2005-06-27 2007-01-04 Bionanophotonics A/S Immobilisation of polypeptides by irradiation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NEVES-PETERSEN M T ET AL: "PHOTONIC ACTIVATION OF DISULFIDE BRIDGES ACHIEVES ORIENTED PROTEIN IMMOBILIZATION ON BIOSENSOR SURFACES", PROTEIN SCIENCE, CAMBRIDGE UNIVERSITY PRESS, CAMBRIDGE, GB, vol. 15, no. 2, 1 February 2006 (2006-02-01), pages 343 - 351, XP009070024, ISSN: 0961-8368 *
SNABE ET AL: "Oriented coupling of major histocompatibility complex (MHC) to sensor surfaces using light assisted immobilisation technology", BIOSENSORS & BIOELECTRONICS, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 21, no. 8, 15 February 2006 (2006-02-15), pages 1553 - 1559, XP005264013, ISSN: 0956-5663 *

Also Published As

Publication number Publication date
WO2008077406A2 (en) 2008-07-03

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