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WO2008074960A3 - New conjugates for therapeutic purposes and/or as diagnosis and/or imaging agents and method for preparing the same - Google Patents

New conjugates for therapeutic purposes and/or as diagnosis and/or imaging agents and method for preparing the same Download PDF

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Publication number
WO2008074960A3
WO2008074960A3 PCT/FR2007/052517 FR2007052517W WO2008074960A3 WO 2008074960 A3 WO2008074960 A3 WO 2008074960A3 FR 2007052517 W FR2007052517 W FR 2007052517W WO 2008074960 A3 WO2008074960 A3 WO 2008074960A3
Authority
WO
WIPO (PCT)
Prior art keywords
diagnosis
preparing
marker
same
therapeutic purposes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2007/052517
Other languages
French (fr)
Other versions
WO2008074960A2 (en
Inventor
Daniel Scherman
Michel Bessodes
Philippe Chaumet-Riffaud
Nathalie Mignet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Centre National de la Recherche Scientifique CNRS
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Centre National de la Recherche Scientifique CNRS
Publication of WO2008074960A2 publication Critical patent/WO2008074960A2/en
Publication of WO2008074960A3 publication Critical patent/WO2008074960A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/081—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the protein being an albumin, e.g. human serum albumin [HSA], bovine serum albumin [BSA], ovalbumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to a method for preparing a conjugate of the general formula (I) or a derivative thereof, in which : P is a physiologically acceptable chemical or biological substrate selected from proteins, polysaccharides, liposome-type vectors or nano- and micro-particles or biocompatible polymers; and Q is a physiologically acceptable chemical or biological entity different from P and of interest in the field of therapy, diagnosis and/or imaging and selected from targeting ligands, markers, marker-chelating agents and/or marker-chelating agents-marker pairs. The invention also relates to the use of such derivatives in the medical field and essentially for diagnosis and/or imaging purposes.
PCT/FR2007/052517 2006-12-14 2007-12-14 New conjugates for therapeutic purposes and/or as diagnosis and/or imaging agents and method for preparing the same Ceased WO2008074960A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0655522 2006-12-14
FR0655522A FR2909881A1 (en) 2006-12-14 2006-12-14 NOVEL CONJUGATES FOR USE IN THERAPEUTIC PURPOSES AND / OR AS DIAGNOSTIC AND / OR IMAGING AGENTS AND METHOD FOR PREPARING THE SAME

Publications (2)

Publication Number Publication Date
WO2008074960A2 WO2008074960A2 (en) 2008-06-26
WO2008074960A3 true WO2008074960A3 (en) 2008-10-23

Family

ID=38255137

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2007/052517 Ceased WO2008074960A2 (en) 2006-12-14 2007-12-14 New conjugates for therapeutic purposes and/or as diagnosis and/or imaging agents and method for preparing the same

Country Status (2)

Country Link
FR (1) FR2909881A1 (en)
WO (1) WO2008074960A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101851313B (en) * 2010-05-17 2011-10-12 北京师范大学 Technetium-99m labeled poly N-vinylbenzyl-D-lactosamide complex and its preparation method
EP3755381B1 (en) 2018-02-21 2025-01-01 Sorbonne Université Optical imaging agents targeting inflammation
WO2020023247A1 (en) * 2018-07-23 2020-01-30 Centurion Biopharma Corporation Imaging agents for radiolabeling exogenous and endogenous albumin
CN113101372B (en) * 2019-12-24 2025-02-14 北京大学 Conjugates with radiation-responsive groups and uses thereof

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5554748A (en) * 1989-04-07 1996-09-10 Nycomed Salutar, Inc. Adducts of macrocyclic chelants
US6310039B1 (en) * 1996-09-11 2001-10-30 Felix Kratz Antineoplastic conjugates of transferrin, albumin and polyethylene glycol
WO2003027148A1 (en) * 2001-09-25 2003-04-03 Jae Min Jeong Disulfide-reduced neogalactosyl serum albumin and use of radiolabeled derivative thereof for liver imaging
WO2003072017A2 (en) * 2002-02-01 2003-09-04 Abbott Laboratories Macromolecular conjugates and processes for preparing same
WO2003096990A2 (en) * 2002-05-17 2003-11-27 Montana State University Protein cages for the delivery of medical imaging and therapy
FR2841554A1 (en) * 2002-07-01 2004-01-02 Commissariat Energie Atomique COMPOUNDS OF MALEIMIDES BRANDS, PROCESS FOR THEIR PREPARATION AND THEIR USE FOR MARKING MACROMOLECULES
WO2004071536A1 (en) * 2003-02-17 2004-08-26 Upperton Limited Conjugates for medical imaging comprising carrier, targeting moiety and a contrast agent
WO2006116742A2 (en) * 2005-04-28 2006-11-02 Ventana Medical Systems, Inc. Fluorescent nanoparticles conjugated to antibodies via a peg linker

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5554748A (en) * 1989-04-07 1996-09-10 Nycomed Salutar, Inc. Adducts of macrocyclic chelants
US6310039B1 (en) * 1996-09-11 2001-10-30 Felix Kratz Antineoplastic conjugates of transferrin, albumin and polyethylene glycol
WO2003027148A1 (en) * 2001-09-25 2003-04-03 Jae Min Jeong Disulfide-reduced neogalactosyl serum albumin and use of radiolabeled derivative thereof for liver imaging
WO2003072017A2 (en) * 2002-02-01 2003-09-04 Abbott Laboratories Macromolecular conjugates and processes for preparing same
WO2003096990A2 (en) * 2002-05-17 2003-11-27 Montana State University Protein cages for the delivery of medical imaging and therapy
FR2841554A1 (en) * 2002-07-01 2004-01-02 Commissariat Energie Atomique COMPOUNDS OF MALEIMIDES BRANDS, PROCESS FOR THEIR PREPARATION AND THEIR USE FOR MARKING MACROMOLECULES
WO2004071536A1 (en) * 2003-02-17 2004-08-26 Upperton Limited Conjugates for medical imaging comprising carrier, targeting moiety and a contrast agent
WO2006116742A2 (en) * 2005-04-28 2006-11-02 Ventana Medical Systems, Inc. Fluorescent nanoparticles conjugated to antibodies via a peg linker

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BANERJEE S R ET AL: "DESIGN AND SYNTHESIS OF SITE DIRECTED MALEIMIDE BIFUNCTIONAL CHELATORS FOR TECHNETIUM AND RHENIUM", JOURNAL OF THE CHEMICAL SOCIETY, SECTION A: INORGANIC, PHYSICAL AND THEORETICAL CHEMISTRY, CHEMICAL SOCIETY. LETCHWORTH, GB, no. 24, 21 December 2005 (2005-12-21), pages 3886 - 3897, XP009075237 *

Also Published As

Publication number Publication date
FR2909881A1 (en) 2008-06-20
WO2008074960A2 (en) 2008-06-26

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