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WO2008071910A3 - Cytokeratin acetylation and detection of hdac5 - Google Patents

Cytokeratin acetylation and detection of hdac5 Download PDF

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Publication number
WO2008071910A3
WO2008071910A3 PCT/GB2007/004598 GB2007004598W WO2008071910A3 WO 2008071910 A3 WO2008071910 A3 WO 2008071910A3 GB 2007004598 W GB2007004598 W GB 2007004598W WO 2008071910 A3 WO2008071910 A3 WO 2008071910A3
Authority
WO
WIPO (PCT)
Prior art keywords
acetylation
cytokeratin
detection
hdac5
cytokeratins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2007/004598
Other languages
French (fr)
Other versions
WO2008071910A2 (en
Inventor
Bernard Corfe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Sheffield
Original Assignee
University of Sheffield
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Sheffield filed Critical University of Sheffield
Publication of WO2008071910A2 publication Critical patent/WO2008071910A2/en
Publication of WO2008071910A3 publication Critical patent/WO2008071910A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4742—Keratin; Cytokeratin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

We describe the detection of the acetylation status of cytokeratin 8 and/or 18 in a biological sample as a diagnostic and/or prognostic tool for disease and also therapeutic agents that modulate the acetylation state of cytokeratins 8 and/or 18.
PCT/GB2007/004598 2006-12-11 2007-11-30 Cytokeratin acetylation and detection of hdac5 Ceased WO2008071910A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0624745A GB0624745D0 (en) 2006-12-11 2006-12-11 Acetylation
GB0624745.6 2006-12-11

Publications (2)

Publication Number Publication Date
WO2008071910A2 WO2008071910A2 (en) 2008-06-19
WO2008071910A3 true WO2008071910A3 (en) 2009-04-02

Family

ID=37711958

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/004598 Ceased WO2008071910A2 (en) 2006-12-11 2007-11-30 Cytokeratin acetylation and detection of hdac5

Country Status (2)

Country Link
GB (1) GB0624745D0 (en)
WO (1) WO2008071910A2 (en)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002050285A2 (en) * 2000-12-20 2002-06-27 Novartis Ag Histone deacetylase-related gene and protein
WO2002102323A2 (en) * 2001-06-14 2002-12-27 Bristol-Myers Squibb Company Novel human histone deacetylases
WO2003045405A2 (en) * 2001-11-27 2003-06-05 Bio-K Plus International Inc. Lactic acid bacteria and their use for treating and preventing cancer
US20030129724A1 (en) * 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
US20040022869A1 (en) * 2001-11-30 2004-02-05 Chen Lan Bo Methods and compositions for modulating the immune system and uses thereof
US20040266718A1 (en) * 2001-08-06 2004-12-30 Zuomei Li Inhibition of specific histone deacetylase isoforms
WO2005016126A2 (en) * 2003-08-15 2005-02-24 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Multifactorial assay for cancer detection
EP1586903A1 (en) * 2004-03-30 2005-10-19 Sysmex Corporation Method for screening cervical cancer

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030129724A1 (en) * 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
WO2002050285A2 (en) * 2000-12-20 2002-06-27 Novartis Ag Histone deacetylase-related gene and protein
WO2002102323A2 (en) * 2001-06-14 2002-12-27 Bristol-Myers Squibb Company Novel human histone deacetylases
US20040266718A1 (en) * 2001-08-06 2004-12-30 Zuomei Li Inhibition of specific histone deacetylase isoforms
WO2003045405A2 (en) * 2001-11-27 2003-06-05 Bio-K Plus International Inc. Lactic acid bacteria and their use for treating and preventing cancer
US20040022869A1 (en) * 2001-11-30 2004-02-05 Chen Lan Bo Methods and compositions for modulating the immune system and uses thereof
WO2005016126A2 (en) * 2003-08-15 2005-02-24 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Multifactorial assay for cancer detection
EP1586903A1 (en) * 2004-03-30 2005-10-19 Sysmex Corporation Method for screening cervical cancer

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DORMEYER WILMA ET AL: "Probing lysine acetylation in proteins: strategies, limitations, and pitfalls of in vitro acetyltransferase assays.", MOLECULAR & CELLULAR PROTEOMICS : MCP SEP 2005, vol. 4, no. 9, September 2005 (2005-09-01), pages 1226 - 1239, XP002480863, ISSN: 1535-9476 *
GIBBS P E ET AL: "Differential post-translational modification of human type I keratins synthesized in a rabbit reticulocyte cell-free system.", BIOCHIMICA ET BIOPHYSICA ACTA 20 MAR 1985, vol. 824, no. 3, 20 March 1985 (1985-03-20), pages 247 - 255, XP002480862, ISSN: 0006-3002 *
GIBSON P R: "The intracellular target of butyrate's actions: HDAC or HDON'T?", GUT APR 2000, vol. 46, no. 4, April 2000 (2000-04-01), pages 447 - 448, XP002505610, ISSN: 0017-5749 *
KOUZARIDES T: "Acetylation: a regulatory modification to rival phosphorylation?", THE EMBO JOURNAL 15 MAR 2000, vol. 19, no. 6, 15 March 2000 (2000-03-15), pages 1176 - 1179, XP002480864, ISSN: 0261-4189 *
OMARY M B ET AL: "Keratin modifications and solubility properties in epithelial cells and in vitro", SUB-CELLULAR BIOCHEMISTRY,, vol. 31, 1 January 1998 (1998-01-01), pages 105 - 140, XP009099742, ISSN: 0306-0225 *
SCHEPPACH W ET AL: "Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis.", GASTROENTEROLOGY JUL 1992, vol. 103, no. 1, July 1992 (1992-07-01), pages 51 - 56, XP009100496, ISSN: 0016-5085 *

Also Published As

Publication number Publication date
GB0624745D0 (en) 2007-01-17
WO2008071910A2 (en) 2008-06-19

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