WO2008067288A3 - Methods for inhibiting foreign body response to implanted materials - Google Patents
Methods for inhibiting foreign body response to implanted materials Download PDFInfo
- Publication number
- WO2008067288A3 WO2008067288A3 PCT/US2007/085598 US2007085598W WO2008067288A3 WO 2008067288 A3 WO2008067288 A3 WO 2008067288A3 US 2007085598 W US2007085598 W US 2007085598W WO 2008067288 A3 WO2008067288 A3 WO 2008067288A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- foreign body
- inhibitors
- gtpase activity
- methods
- rho
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/432—Inhibitors, antagonists
- A61L2300/434—Inhibitors, antagonists of enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Methods and compositions for inhibiting the foreign body response to implanted materials are described herein. The methods include inhibiting the formation of foreign body giant cells by administering an effective amount of an antagonist of Rho GTPase activity. In a preferred embodiment, the methods include contacting an implanted material or the adjacent tissue or bodily fluids with an effective amount of a Rho GTPase antagonist to prevent formation of multinucleated foreign body giant cells at the implantation site. Inhibitors of Rho GTPase activity may be provided separately from the implanted material, or alternatively, may be provided as a component of the external surface of the implanted material. The methods include contacting monocytes or macrophages with inhibitors of Rho family GTPase activity in amounts effective to inhibit fusion of these cells to form multinucleated foreign body giant cells. Inhibitors of Rho GTPase activity are preferably inhibitors of Rac family GTPase activity. In a preferred embodiment, the small molecule Rac inhibitor NSC23766 is used.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86729206P | 2006-11-27 | 2006-11-27 | |
| US60/867,292 | 2006-11-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2008067288A2 WO2008067288A2 (en) | 2008-06-05 |
| WO2008067288A3 true WO2008067288A3 (en) | 2008-08-07 |
Family
ID=39366994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2007/085598 Ceased WO2008067288A2 (en) | 2006-11-27 | 2007-11-27 | Methods for inhibiting foreign body response to implanted materials |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2008067288A2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130324521A1 (en) * | 2010-11-26 | 2013-12-05 | Reza Ghotbi | Implant for treating or preventing an aneurysm |
| WO2022076700A1 (en) * | 2020-10-07 | 2022-04-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for the treatment of implant associated complications |
| WO2024049713A1 (en) * | 2022-08-30 | 2024-03-07 | Lintec Of America, Inc. | Improved nerve regeneration scaffold for accelerated regrowth |
| EP4630014A1 (en) | 2022-12-09 | 2025-10-15 | CeMM - Forschungszentrum für Molekulare Medizin GmbH | Method for optimizing t cells for immuno-therapy |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030130722A1 (en) * | 2001-12-21 | 2003-07-10 | Marx Steven O. | C3 exoenzyme-coated stents and uses thereof for treating and preventing restenosis |
| WO2003105923A2 (en) * | 2002-06-14 | 2003-12-24 | The Trustees Of Columbia University In The City Ofnew York | Use of y-27632 as an agent to prevent restenosis after coronary artery angioplasty/stent implantation |
-
2007
- 2007-11-27 WO PCT/US2007/085598 patent/WO2008067288A2/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030130722A1 (en) * | 2001-12-21 | 2003-07-10 | Marx Steven O. | C3 exoenzyme-coated stents and uses thereof for treating and preventing restenosis |
| WO2003105923A2 (en) * | 2002-06-14 | 2003-12-24 | The Trustees Of Columbia University In The City Ofnew York | Use of y-27632 as an agent to prevent restenosis after coronary artery angioplasty/stent implantation |
Non-Patent Citations (3)
| Title |
|---|
| GOWER T L ET AL: "RhoA is activated during respiratory syncytial virus infection", VIROLOGY, vol. 283, 2001, pages 188 - 196, XP002480818 * |
| GOWER T L ET AL: "RhoA signalling is required for respiratory syncytial virus-induced syncytium formation and filamentous virion morphology", JOURNAL OF VIROLOGY, vol. 79, no. 9, May 2005 (2005-05-01), pages 5326 - 5336, XP002480817 * |
| ORY S ET AL: "Rho and Rac exert antagonistic functions on spreading of macrophage-derived multinucleated cells and are not required for actin fiber formation", JOURNAL OF CELL SCIENCE, vol. 113, 2000, pages 1177 - 1188, XP002480819 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008067288A2 (en) | 2008-06-05 |
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