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WO2008067195A3 - Carte génétique des gènes humains associés à la maladie de crohn - Google Patents

Carte génétique des gènes humains associés à la maladie de crohn Download PDF

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Publication number
WO2008067195A3
WO2008067195A3 PCT/US2007/084977 US2007084977W WO2008067195A3 WO 2008067195 A3 WO2008067195 A3 WO 2008067195A3 US 2007084977 W US2007084977 W US 2007084977W WO 2008067195 A3 WO2008067195 A3 WO 2008067195A3
Authority
WO
WIPO (PCT)
Prior art keywords
crohn
disease
genemap
genes associated
human genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/084977
Other languages
English (en)
Other versions
WO2008067195A2 (fr
WO2008067195A8 (fr
Inventor
Abdelmajid Belouchi
John Verner Raelson
Andre Franke
Andre Schreiber
Quynh Nguyen-Huu
Pascal Croteau
Valeri Perepetchai
Rene Allard
Claudia Reinhard
Vanessa Bruat
Eerdewegh Paul Van
Jonathon Segal
Randall David Little
Tim Keith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genizon Biosciences Inc
Original Assignee
Genizon Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genizon Biosciences Inc filed Critical Genizon Biosciences Inc
Priority to CA002668691A priority Critical patent/CA2668691A1/fr
Priority to US12/312,580 priority patent/US20100291551A1/en
Priority to EP07871507A priority patent/EP2097540A4/fr
Publication of WO2008067195A2 publication Critical patent/WO2008067195A2/fr
Publication of WO2008067195A3 publication Critical patent/WO2008067195A3/fr
Anticipated expiration legal-status Critical
Publication of WO2008067195A8 publication Critical patent/WO2008067195A8/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne la sélection d'un ensemble de marqueurs de polymorphismes utilisés dans des études d'association sur l'ensemble du génome sur la base de la cartographie de déséquilibre de liaison. Cette invention relève en particulier des domaines de la pharmacogénomique, du diagnostic, du traitement des patients et de l'utilisation d'informations relatives aux haplotypes génétiques pour prédire, chez un individu, le risque de développer une maladie intestinale inflammatoire (IBD) (telle que la maladie de Crohn) et/ou sa réponse à un ou plusieurs médicaments particuliers.
PCT/US2007/084977 2006-11-17 2007-11-16 Carte génétique des gènes humains associés à la maladie de crohn Ceased WO2008067195A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002668691A CA2668691A1 (fr) 2006-11-17 2007-11-16 Carte genetique des genes humains associes a la maladie de crohn
US12/312,580 US20100291551A1 (en) 2006-11-17 2007-11-16 Genemap of the human associated with crohn's disease
EP07871507A EP2097540A4 (fr) 2006-11-17 2007-11-16 Carte génétique des gènes humains associés à la maladie de crohn

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85954606P 2006-11-17 2006-11-17
US60/859,546 2006-11-17

Publications (3)

Publication Number Publication Date
WO2008067195A2 WO2008067195A2 (fr) 2008-06-05
WO2008067195A3 true WO2008067195A3 (fr) 2008-11-27
WO2008067195A8 WO2008067195A8 (fr) 2009-11-05

Family

ID=39468622

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/084977 Ceased WO2008067195A2 (fr) 2006-11-17 2007-11-16 Carte génétique des gènes humains associés à la maladie de crohn

Country Status (4)

Country Link
US (1) US20100291551A1 (fr)
EP (1) EP2097540A4 (fr)
CA (1) CA2668691A1 (fr)
WO (1) WO2008067195A2 (fr)

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Publication number Priority date Publication date Assignee Title
IL189408A0 (en) 2008-02-10 2009-02-11 Yeda Res & Dev Siva3, its preparation and pharmaceutical compositions containing it
EP2307046B1 (fr) * 2008-06-11 2017-01-25 aTyr Pharma, Inc. Activité thrombopoïétique de polypeptides de tyrosyl-arnt synthétase
CN102171365B (zh) * 2008-08-25 2014-01-29 森托科尔奥索生物科技公司 用于溃疡性结肠炎和相关疾病的抗tnf治疗的生物标记物
US9512196B2 (en) 2008-09-22 2016-12-06 Cedars-Sinai Medical Center Short-form human MD-2 as a negative regulator of toll-like receptor 4 signaling
EP2328911A4 (fr) 2008-09-22 2012-03-14 Cedars Sinai Medical Center Md-2 humaine sous sa forme courte utilisée comme régulateur négatif de la signalisation par le récepteur de type toll-4
WO2010062960A2 (fr) 2008-11-26 2010-06-03 Cedars-Sinai Medical Center Méthodes de détermination d'une réceptivité à une thérapie par anti-tnfα lors d’une maladie intestinale inflammatoire
KR101155506B1 (ko) * 2009-07-08 2012-06-15 고려대학교 산학협력단 활성산소조절 유전자를 이용한 ｔｎｆ-알파 유도 질병의 치료제 및 예방제의 스크리닝 방법
CN102770767A (zh) * 2010-02-10 2012-11-07 诺瓦提斯公司 用于肌肉生长的方法和组合物
JP2011244760A (ja) * 2010-05-28 2011-12-08 Sumitomo Chemical Co Ltd 生体組織再生を促進させる薬剤を製造するための加工細胞
PT2670769T (pt) * 2011-02-03 2019-06-28 Janssen Pharmaceutica Nv R2r1/2 em diagnóstico e terapêutica
US9114128B2 (en) * 2011-09-30 2015-08-25 Protein Genomics, Inc. Tropoelastins and uses thereof
ES2757942T3 (es) * 2012-05-21 2020-04-30 Penn State Res Found Composiciones y métodos relacionados con la variante 2 de dennd1a y síndrome de ovario poliquístico
CN112870368A (zh) 2013-03-27 2021-06-01 西达-赛奈医疗中心 通过抑制tl1a的功能和相关信号传导途径来减轻并逆转纤维化和炎症
DE102013005361A1 (de) * 2013-03-28 2014-10-02 Eberhard Karls Universität Tübingen Medizinische Fakultät Polyribonucleotid
KR101497204B1 (ko) * 2013-04-01 2015-03-09 울산대학교 산학협력단 크론병 감수성 진단용 폴리뉴클레오티드 마커 조성물
WO2015010108A1 (fr) 2013-07-19 2015-01-22 Cedars-Sinai Medical Center Signature de la voie de signalisation de tl1a (tnfsf15)
US10765728B2 (en) * 2014-04-11 2020-09-08 Cellectis Method for generating immune cells resistant to arginine and/or tryptophan depleted microenvironment
KR101545097B1 (ko) 2014-09-18 2015-08-18 울산대학교 산학협력단 크론병 감수성 진단용 폴리뉴클레오티드 마커 조성물
KR101497282B1 (ko) * 2014-09-18 2015-03-05 울산대학교 산학협력단 크론병 감수성 진단용 폴리뉴클레오티드 마커 조성물
US9873914B2 (en) 2015-01-30 2018-01-23 Enterome Host DNA as a biomarker of Crohn's disease
WO2017125586A2 (fr) * 2016-01-22 2017-07-27 Academisch Ziekenhuis Leiden (Also Acting Under The Name Of Leiden University Medical) Protéines et peptides dérivés du gène de l'insuline pour utilisation dans le diagnostic et le traitement du diabète de type 1
CN118773299A (zh) 2016-03-17 2024-10-15 西达-赛奈医疗中心 通过rnaset2诊断炎性肠病的方法
GB201609193D0 (en) 2016-05-25 2016-07-06 Immatics Biotechnologies Gmbh Novel peptides, combination of peptides as targets for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers
JP7075125B2 (ja) 2016-05-25 2022-05-25 イマティクス バイオテクノロジーズ ゲーエムベーハー 標的としてのおよび胆嚢がんおよび胆管がんおよびその他のがんに対する免疫療法で使用するための新規ペプチド、ペプチド組み合わせ
CN117487816B (zh) * 2023-11-03 2024-06-04 中山大学孙逸仙纪念医院 Znf709基因在制备治疗pbc的药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040077020A1 (en) * 2001-11-30 2004-04-22 Mannick Elizabeth E. Diagnostic microarray for inflammatory bowel disease, crohn's disease and ulcerative colitis

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Publication number Priority date Publication date Assignee Title
US20040076960A1 (en) * 2002-10-18 2004-04-22 Taylor Kent D. Methods of using a NOD2/CARD15 haplotype to diagnose Crohn's disease
CA2606341A1 (fr) * 2005-04-29 2006-11-09 Genizon Biosciences Inc. Carte genetique des genes humains associes a la maladie de crohn
CA2620082A1 (fr) * 2005-08-24 2007-03-01 Genizon Biosciences Inc. Carte genetique de genes humains associes a la maladie de crohn
CA2634146A1 (fr) * 2005-12-19 2007-06-28 Genizon Biosciences Inc. Carte genetique du gene humain associe a la maladie de crohn

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
US20040077020A1 (en) * 2001-11-30 2004-04-22 Mannick Elizabeth E. Diagnostic microarray for inflammatory bowel disease, crohn's disease and ulcerative colitis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LAWRANCE I.C. ET AL.: "Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility", HUMAN MOLECULAR GENETICS, vol. 10, no. 5, October 2001 (2001-10-01), pages 445 - 456, XP002955653 *
MCCARTHY ET AL., GENOME BIOLOGY, vol. 4, September 2003 (2003-09-01), pages 119.1 - 119.8, XP008109753 *
RIOUX J.D. ET AL.: "GENOWIDE SEARCH IN CANADIAN FAMILIES WITH INFLAMMATORY BOWEL DISEASE REVEALS TWO NOVEL SUSCEPTIBILITY LOCI", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 66, no. 6, April 2000 (2000-04-01), pages 1863 - 1870, XP001016365 *
See also references of EP2097540A4 *

Also Published As

Publication number Publication date
WO2008067195A2 (fr) 2008-06-05
US20100291551A1 (en) 2010-11-18
WO2008067195A8 (fr) 2009-11-05
EP2097540A4 (fr) 2010-09-01
CA2668691A1 (fr) 2008-06-05
EP2097540A2 (fr) 2009-09-09

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