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WO2008066729A3 - Boronic acid containing compositions - Google Patents

Boronic acid containing compositions Download PDF

Info

Publication number
WO2008066729A3
WO2008066729A3 PCT/US2007/024173 US2007024173W WO2008066729A3 WO 2008066729 A3 WO2008066729 A3 WO 2008066729A3 US 2007024173 W US2007024173 W US 2007024173W WO 2008066729 A3 WO2008066729 A3 WO 2008066729A3
Authority
WO
WIPO (PCT)
Prior art keywords
boronic acid
acid containing
containing compositions
potency
manufacturing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/024173
Other languages
French (fr)
Other versions
WO2008066729A2 (en
Inventor
Michael A Tyo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dara Biosciences Inc
Original Assignee
Dara Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dara Biosciences Inc filed Critical Dara Biosciences Inc
Publication of WO2008066729A2 publication Critical patent/WO2008066729A2/en
Publication of WO2008066729A3 publication Critical patent/WO2008066729A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides clinical grade compositions comprising peptide boronic acids, and methods of manufacturing the same to avoid degradation and maintain stability and potency.
PCT/US2007/024173 2006-11-22 2007-11-19 Boronic acid containing compositions Ceased WO2008066729A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86068606P 2006-11-22 2006-11-22
US60/860,686 2006-11-22

Publications (2)

Publication Number Publication Date
WO2008066729A2 WO2008066729A2 (en) 2008-06-05
WO2008066729A3 true WO2008066729A3 (en) 2008-09-25

Family

ID=39468462

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/024173 Ceased WO2008066729A2 (en) 2006-11-22 2007-11-19 Boronic acid containing compositions

Country Status (1)

Country Link
WO (1) WO2008066729A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104478912A (en) * 2014-12-20 2015-04-01 成都安斯利生物医药有限公司 Method for preparing saturated potassium azacyclo-trifluoroborates
RU2711380C2 (en) * 2015-07-16 2020-01-16 Байоксэл Терапьютикс, Инк. New approach to treating cancer with application of immunomodulation
CN110452258B (en) * 2019-09-03 2021-01-01 上海馨远医药科技有限公司 Preparation method of dipeptide valine boron proline salt
CN111537622B (en) * 2019-11-29 2021-11-26 杭州华东医药集团新药研究院有限公司 Method for detecting impurities of duloxetine and salts thereof
CN114113402B (en) * 2021-12-03 2023-05-23 重庆医药高等专科学校 Method for measuring pinanediol content in bortezomib by adopting high performance liquid chromatography

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GIBSON ET AL.: "A Practical Synthesis of L-Valyl-pyrrolidine-(2R)-boronic Acid: Efficient Recycling of the Costly Chiral Auxiliary (+)-Pinanediol", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 6, 2002, pages 814 - 816, XP009075554 *
ICHIKAWA ET AL.: "HPLC Determination of (+)-Pseudoephedrine and (-)-Ephedrine in Japanese Herbal Medicines Containing Ephedra Herb Using Solid-Phase Extraction", CHEM. PHARM. BULL., vol. 51, 2003, pages 635 - 639 *
LACROIX ET AL.: "Fenofibrate raw materials: HPLC methods for assay and purity and an NMR method for purity", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 18, 1998, pages 383 - 402 *

Also Published As

Publication number Publication date
WO2008066729A2 (en) 2008-06-05

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