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WO2008066707A3 - Targeting prohormone convertase enzymes to suppress pomc-msh processing to induce skin lightening - Google Patents

Targeting prohormone convertase enzymes to suppress pomc-msh processing to induce skin lightening Download PDF

Info

Publication number
WO2008066707A3
WO2008066707A3 PCT/US2007/023940 US2007023940W WO2008066707A3 WO 2008066707 A3 WO2008066707 A3 WO 2008066707A3 US 2007023940 W US2007023940 W US 2007023940W WO 2008066707 A3 WO2008066707 A3 WO 2008066707A3
Authority
WO
WIPO (PCT)
Prior art keywords
pomc
msh
targeting
suppress
skin lightening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/023940
Other languages
French (fr)
Other versions
WO2008066707A2 (en
Inventor
David E Fisher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Dana Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Publication of WO2008066707A2 publication Critical patent/WO2008066707A2/en
Publication of WO2008066707A3 publication Critical patent/WO2008066707A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Methods and compositions useful for reducing skin pigmentation and hyperpigmentation are provided. The pigmentation or hyperpigmentation reduced according to the methods of the invention can arise independent of a UV-induced tanning response. Also provided are methods for identifying a candidate skin lightening agent. The methods and compositions of the invention are useful for treatment of a number of conditions, including age spots (also variously known as liver spots, sun spots, solar lentigo, and lentigines).
PCT/US2007/023940 2006-11-29 2007-11-14 Targeting prohormone convertase enzymes to suppress pomc-msh processing to induce skin lightening Ceased WO2008066707A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86145706P 2006-11-29 2006-11-29
US60/861,457 2006-11-29

Publications (2)

Publication Number Publication Date
WO2008066707A2 WO2008066707A2 (en) 2008-06-05
WO2008066707A3 true WO2008066707A3 (en) 2008-10-23

Family

ID=39468452

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/023940 Ceased WO2008066707A2 (en) 2006-11-29 2007-11-14 Targeting prohormone convertase enzymes to suppress pomc-msh processing to induce skin lightening

Country Status (1)

Country Link
WO (1) WO2008066707A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119818494A (en) * 2025-01-07 2025-04-15 中南大学湘雅医院 Application of fraapine and analogues thereof in preparation of drugs for treating pigment dermatosis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004009113A1 (en) * 2002-07-24 2004-01-29 Renovo Limited Use of convertase inhibitors in the treatment of fibrosis and scarring

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004009113A1 (en) * 2002-07-24 2004-01-29 Renovo Limited Use of convertase inhibitors in the treatment of fibrosis and scarring

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BASAK A.: "Inhibitors of Proprotein Convertases", J. MOL. MED., vol. 83, 2005, pages 844 - 855, XP019320304 *
EVES C.E. ET AL.: "Alpha-Melanocyte Stimulating Hormone, Inflammation, and Human Melanoma", PEPTIDES, vol. 27, no. 2, February 2006 (2006-02-01), pages 444 - 452, XP005269003 *
FUKUZAWA T. ET AL.: "Control of Melanoblast Differentiation in Amphibia by alpha-Melanocyte Stimulating Hormone, a Serum Melanization Factor, and a Melanization Inhibiting Factor", PIGMENT CELL RESEARCH, vol. 2, no. 3, 1989, pages 171 - 181 *
SPENCER J.D. ET AL.: "A Novel Mechanism in Control of Human Pigmentation by Beta-Melanocyte-Stimulating Hormone and 7-tetrahydrobiopterin", J. ENDOCRINOLOGY, vol. 187, 2005, pages 293 - 302, XP009071625 *
SUZUKI I. ET AL.: "Increase of Pro-opiomelanocortin mRNA Prior to Tyrosinase-Related Protein 1, Dopachrome Tautomerase, Pmel-17/gp100, and P-Protein mRNA in Human Skin After Ultraviolet B Irradiation", J. INVEST. DERM., vol. 118, no. 1, January 2002 (2002-01-01), pages 73 - 78 *

Also Published As

Publication number Publication date
WO2008066707A2 (en) 2008-06-05

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